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Status
TRIAL

Term Description

This term is intended to collate similar measurements for the LOINC SNOMED CT Collaboration in an ontological view. Additionally, it can be used to communicate a laboratory order, either alone or in combination with specimen or other information in the order. It may NOT be used to report back the measured patient value. https://lo.inc/ce2mb6

Part Descriptions

LP40154-4   Voltage-gated calcium channel PQ type binding Ab
Lambert-Eaton myasthenic syndrome (LEMS) is a rare autoimmune disorder that is characterised by muscle weakness of the limbs. It is the result of an autoimmune reaction, where antibodies are formed against presynaptic voltage-gated calcium channels in the neuromuscular junction (the connection between nerves and the muscle that they supply). Around 60% of those with LEMS have an underlying malignancy, most commonly small cell lung cancer; it is therefore regarded as a paraneoplastic syndrome (a condition that arises as a result of cancer elsewhere in the body).

In LEMS, antibodies against voltage-gated calcium channels (VGCC), particularly the P/Q-type VGCC, decrease the amount of calcium that can enter the nerve ending, hence less acetylcholine can be mobilized to the neuromuscular junction. Apart from skeletal muscle, the autonomic nervous system also requires acetylcholine neurotransmission; this explains the occurrence of autonomic symptoms in LEMS. P/Q voltage-gated calcium channels are also found in the cerebellum, explaining why some experience problems with coordination. The antibodies bind particularly to the part of the receptor known as the "domain III S5-S6 linker peptide". Antibodies may also bind other VGCCs. Some have antibodies that bind synaptotagmin, a protein involved in calcium-regulated vesicle transport, rather than against VGCC. Many people with LEMS, both with and without VGCC antibodies, have detectable antibodies against the M1 subtype of the acetylcholine receptor; it is thought that their presence participates in a lack of compensation for the slow calcium influx. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

LP447904-6   {Measurement}
{Measurement} is a Property grouper part used to collate terms with comparable measurement-related properties. It encompasses the following LOINC Properties: ACnc, AFr, ARat, CAct, CCnc, CCnt, CRat, CSub, EntLen, LaCnc, LnCnc, Mass, MCnc, MCnt, MRat, MRto, MSCnc, MSRat, Naric, NCnc, NFr, Prctl, PrThr, Ratio, SatFr, SCnc, SCnt, SRat, SRto, Sub, ThreshNum, Titr, and TmMCn. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Voltage-gated calcium channel PQ type binding Ab:{Measurement}:-:Ser:-:
Long Common Name
Voltage-gated calcium channel P/Q type binding Ab [Measurement] in Serum
Short Name
VGCC-P/Q Bind Ab Msmt Ser
Display Name
Voltage-gated calcium channel P/Q type binding Ab (S) [Measurement]
Consumer Name Alpha Get Info
Voltage-gated calcium channel p/Q type binding antibody, Blood

Part Model Get Info

  • Component
    Voltage-gated calcium channel PQ type binding Ab
    LP40154-4
    • Analyte
      Voltage-gated calcium channel PQ type binding Ab
      LP40154-4
      • Component Numerator
        Voltage-gated calcium channel PQ type binding Ab
        LP40154-4
        • Component Numerator Core
          Voltage-gated calcium channel PQ type binding
          LP31738-5
        • Component Numerator Core Suffix
          Ab
          LP20667-9
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    {Measurement}
    LP447904-6
  • Time
    -
    LP70420-2
  • System
    Ser
    LP7567-3
    • System Core
      Ser
      LP7567-3
    • Super System
      NULL
       
  • Scale
    -
    LP7747-1
  • Method
    NULL
     

Basic Attributes

Class
LABORDERS.ONTOLOGY
Type
Laboratory
First Released
Version 2.81
Last Updated
Version 2.81 (ADD)
Order vs. Observation
Order

Language Variants Get Info

TagLanguageTranslation
es-ESSpanish (Spain)Canales de calcio dependientes de voltaje tipo PQ Anticuerpos:Medición:-:Suero:-:
fr-FRFrench (France)Canaux calciques voltage dépendants type PQ Ac:{Mesure}:-:Sérum:-:
it-ITItalian (Italy)Canale del calcio voltaggio-dipendente di tipo PQ, legante Ab:{Misurazione}:-:Siero:-:
Synonyms: anticorpo Codici richieste di laboratorio LABORDERS.ONTOLOGY legante il canale del calcio voltaggio-dipendente Misurazione Siero
zh-CNChinese (China)PQ 型电压门控钙离子通道结合 抗体:{检测}:-:血清:-:
Synonyms: {测量};{测定};{检测结果};{测量结果};{测定结果} Ab;自身抗体 CA;Cal PQ 型电压门控钙离子通道结合 Ab 型 多重;多重型;多重标尺类型;多重精度类型 实验室检验项目医嘱类;检验项目医嘱;检验项目申请;化验项目申请 检验申请.本体;实验室检验医嘱.本体 电压依赖性钙离子通道;电压门控式钙离子通道;电压门控式钙通道;电压门控性钙离子通道;电压门控性钙通道;电压门控钙通道 电压门控钙离子通道 PQ 型结合 电压门控钙离子通道 PQ 型结合 Ab 电压门控钙离子通道 PQ 型结合抗体 结合性 结合性的

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=109124-8