110368-8
Kynurenate [Measurement] in Urine
Trial
Status Information
- Status
- TRIAL
Term Description
This term is intended to collate similar measurements for the LOINC SNOMED CT Collaboration in an ontological view. Additionally, it can be used to communicate a laboratory order, either alone or in combination with specimen or other information in the order. It may NOT be used to report back the measured patient value. https://lo.inc/ce2mb6
Part Descriptions
LP15684-1 Kynurenate
Kynurenic acid (KYNA) is a product of the normal metabolism of amino acid L-tryptophan. It has been shown that kynurenic acid possesses neuroactive activity. It acts as an antiexcitotoxic and anticonvulsant, most likely through acting as an antagonist at excitatory amino acid receptors. Because of this activity, it may influence important neurophysiologic and neuropathologic processes. As a result, kynurenic acid has been considered for use in therapy in certain neurobiological disorders. Conversely, increased levels of kynurenic acid have also been linked to certain pathological conditions.
High levels of kynurenic acid have been identified in patients suffering from tick-borne encephalitis, schizophrenia and HIV-related illnesses. In all these situations increased levels were associated with confusion and psychotic symptoms. Kynurenic acid acts in the brain as a glycine-site NMDAr antagonist, key in glutamatergic neurotransmission system, which is thought to be involved in the pathophysiology and pathogenesis of schizophrenia.
A kynurenic acid hypothesis of schizophrenia has been proposed in 2007, based on its action on midbrain dopamine activity and NMDArs, thus linking dopamine hypothesis of schizophrenia with the glutamate hypothesis of the disease.
High levels of kynurenic acid have been identified in human urine in certain metabolic disorders, such as marked pyridoxine deficiency and deficiency/absence of kynureninase.
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Source: Wikipedia,
Kynurenic acid
LP447904-6 {Measurement}
{Measurement} is a Property grouper part used to collate terms with comparable measurement-related properties. It encompasses the following LOINC Properties: ACnc, AFr, ARat, CAct, CCnc, CCnt, CRat, CSub, EntLen, LaCnc, LnCnc, Mass, MCnc, MCnt, MRat, MRto, MSCnc, MSRat, Naric, NCnc, NFr, Prctl, PrThr, Ratio, SatFr, SCnc, SCnt, SRat, SRto, Sub, ThreshNum, Titr, and TmMCn.
Source: Regenstrief LOINC
LOINC Names Get Info
- Fully-Specified Name
- Kynurenate:
{Measurement}: -: Urine: -: - Long Common Name
- Kynurenate [Measurement] in Urine
- Short Name
- KYN Msmt Ur
- Display Name
- Kynurenate (U) [Measurement]
- Consumer Name Alpha Get Info
- Kynurenate, Urine
Part Model Get Info
Basic Attributes
- Class
- LABORDERS.ONTOLOGY
- Type
- Laboratory
- First Released
- Version 2.81
- Last Updated
- Version 2.81 (ADD)
- Order vs. Observation
- Order
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Quinurenato: |
| fr-FR | French (France) | Cynurénate: |
| it-IT | Italian (Italy) | Chinurenato: Synonyms: Codici richieste di laboratorio LABORDERS.ONTOLOGY Misurazione |
| zh-CN | Chinese (China) | 犬尿氨酸: Synonyms: {测量}; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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LOINC Copyright
Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://