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Part Description

LP15085-1   Pronormoblasts
A proerythroblast (or rubriblast, or pronormoblast) is the earliest of four stages in development of the normoblast.

In histology, it is very difficult to distinguish it from the other "-blast" cells (lymphoblast, myeloblast, monoblast, and megakaryoblast). The cytoplasm is blue in an H&E stain, indicating that it is basophilic.

Proerythroblasts arise from the CFU-e (colony-forming unit erythroid) cells, and give rise to basophilic erythroblasts. In the mouse, proerythroblasts are large committed progenitors that express high levels of transferrin receptor (iron acquisition receptor), the erythropoietin receptor (EpoR), some c-Kit (stem cell factor receptor), and are Ter119 (cell surface molecule)-positive. Their proliferative capacity is more limited compared to the preceding stage, the CFU-e.

In vivo, starting with the proerythroblast stage, erythroid cells undergo several more cell divisions while at the same time upregulating survival genes such as Bcl-xL, acquiring and storing large amounts of iron, ramping up the synthesis of hemoglobin and other erythroid genes (in large part a GATA-1 dependent process that is augmented by the EpoR signaling) and decreasing in cell size, eventually removing their nuclei and being released into the bloodstream as a reticulocyte. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

LOINC Names Get Info

Fully-Specified Name
Pronormoblasts:NCnc:Pt:Bld:Qn:
Long Common Name
Pronormoblasts [#/volume] in Blood
Short Name
Pronormoblasts # Bld
Display Name
Pronormoblasts (Bld) [#/Vol]
Consumer Name Alpha Get Info
Pronormoblasts, Blood

Part Model Get Info

  • Component
    Pronormoblasts
    LP15085-1
    • Analyte
      Pronormoblasts
      LP15085-1
      • Component Numerator
        Pronormoblasts
        LP15085-1
        • Component Numerator Core
          Pronormoblasts
          LP15085-1
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    NCnc
    LP6836-3
  • Time
    Pt
    LP6960-1
  • System
    Bld
    LP7057-5
    • System Core
      Bld
      LP7057-5
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    NULL
     

Basic Attributes

Class
HEM/BC
Type
Laboratory
First Released
Version 1.0j-a
Last Updated
Version 2.42 (MIN)
Order vs. Observation
Observation

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Pronormoblasty:Početní koncentrace:Časový bod:Krev:Kvantitativní:
el-GRGreek (Greece)Προνορμοβλάστες:NCnc:Pt:Αίμα:Qn:
Synonyms: HEM/BC NCnc Pt Qn Αίμα Προνορμοβλάστες
es-ARSpanish (Argentina)pronormoblastos:concentración de número:punto en el tiempo:sangre:cuantitativo:
es-ESSpanish (Spain)Pronormoblastos:Concentración de número:Punto temporal:Sangre:Qn:
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Pronormoblastos:Concentración numérica:Punto temporal:Sangre:Cuantitativo:
et-EEEstonian (Estonia)Pronormoblastid:NCnc:Pt:B:Qn:
Synonyms: Juhuslik Kvantitatiivne Veri
fr-CAFrench (Canada)Pronormoblastes:Concentration numérique:Temps ponctuel:Sang:Quantitatif:
fr-FRFrench (France)Proérythroblastes:Nombre/Volume:Ponctuel:Sang:Numérique:
fr-BEFrench (Belgium)Pronormoblastes:Concentration numérique:Temps ponctuel:Sang:Quantitatif:
it-ITItalian (Italy)Pronormoblasti:NCnc:Pt:Sangue:Qn:
Synonyms: Concentrazione Numerica Ematologia (coagulazione) conta differenziale Punto nel tempo (episodio) Sangue
ko-KRKorean (Korea, Republic Of)전적혈모구:계수/부피:검사시점:전혈:정량:
nl-NLDutch (Netherlands)pronormoblasten:aantal/volume:moment:bloed:kwantitatief:
pl-PLPolish (Poland)Pronormoblast:stężenie liczbowe:punkt w czasie:krew:ilościowy:
Synonyms: koncentracja Pronormoblast
pt-BRPortuguese (Brazil)Pronormoblastos:NCnc:Pt:SgTotal:Qn:
Synonyms: Pronormoblast; Rubriblast; Proerythroblast; Proerythroblasts; Early erythroblast; #; Number concentration; Count/mass; Count; AcS; CT; Acsolute; Acsolutes; Cnt; Point in time; Random; Blood; WB; Whole blood; Quantitative; QNT; Quant; Quan; HEMATOLOGY/CELL COUNTS; HEMATOLOGY/CELL COUNTS
ru-RURussian (Russian Federation)Пронормобласты:КолОб:ТчкВрм:Кр:Колич:
Synonyms: Количественный Количество в объеме Кровь Точка во времени;Момент
tr-TRTurkish (Turkey)Pronormoblastlar:SayKons:Zmlı:Kan:Kant:
zh-CNChinese (China)原红细胞:计数型浓度:时间点:全血:定量型:
Synonyms: 前成红细胞;原始红;原始红细胞;原成红细胞;原正成红细胞;原红;早期成红细胞;早期成红血球细胞;早期有核红血球 单位体积内的数量或计数;数量型浓度(单位体积);数量或计数型浓度(计数/体积);数量或计数型浓度(单位体积);计数型浓度(单位体积) 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 血;血液 血液学/细胞计数;血液学与细胞计数

Example Units

UnitSource
/uLExample UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=11129-4