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Term Description

This term represents a test which measures biophysical and morphological changes in leukocytes (white blood cells) that occur during immune activation and dysregulation, with a specific focus on detecting sepsis. The test analyzes circulating neutrophils, monocytes, and other white blood cells using microfluidic technology to quantify cellular mechanical properties-particularly visco-elastic inertial response (VEIR): which reflects cell density, size, deformability, and viscosity. These biophysical properties change dramatically during leukocyte activation, including nuclear rearrangement and the early stages of neutrophil extracellular trap (NET) formation, processes characteristic of dysregulated immunity in sepsis. PMID: 37189536

Part Description

LP20670-3   Leukocyte
Leukocytes or white blood cells (WBCs) are immune cells that fight infection, neoplasms and other inflammatory conditions, and mediate allergic responses. There are five types of WBCs normally present in the circulation that are all derived from a similar stem cell in the bone marrow. The five type of WBCs are divided into two groups based on the presence or absence of granules in the cytoplasm. The granulocytes include the neutrophils, basophils and eosinophils. The non-granulocytes include the lymphocytes and the monocytes. The neutrophils fight infection by ingesting and digesting bacteria. Eosinophils and basophils respond to allergic reactions and are capable of ingesting antigen-antibody complexes. Monocytes phagocytose bacteria and release interferon to stimulate the immune system. Lymphocytes are divided into T-cells and B-cells. T-cell immunity is cellular and involves the activation of phagocytes and B-cell immunity uses antibodies to fight infection. Both elevated and low leukocyte counts can be markers of infection and malignancy, and low leukocyte counts are associated with a variety of primary and secondary immunodeficiencies, depending on the WBC type(s) that are out of range. (Mosby's manual of diagnostic and laboratory tests, Kathleen Deska Pagana; Timothy James Pagana, Elsevier St. Louis, Mo ©2010) Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Leukocyte deformability sepsis assessment:Imp:Pt:Bld:OrdQn:Cytometry.microfluidic
Long Common Name
Leukocyte deformability sepsis assessment [Interpretation] in Blood by Microfluidic deformability cytometer
Short Name
Leuk deform sepsis Bld Microfl cyt-Imp
Display Name
Leukocyte deformability sepsis assessment Microfluidic deformability cytometer (Bld) [Interp]
Consumer Name Alpha Get Info
Leukocyte deformability sepsis assessment, Blood

Part Model Get Info

  • Component
    Leukocyte deformability sepsis assessment
    LP450059-3
    • Analyte
      Leukocyte deformability sepsis assessment
      LP450059-3
      • Component Numerator
        Leukocyte deformability sepsis assessment
        LP450059-3
        • Component Numerator Core
          Leukocyte deformability sepsis assessment
          LP450059-3
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Imp
    LP6819-9
  • Time
    Pt
    LP6960-1
  • System
    Bld
    LP7057-5
    • System Core
      Bld
      LP7057-5
    • Super System
      NULL
       
  • Scale
    OrdQn
    LP7752-1
  • Method
    Cytometry.microfluidic
    LP450299-5

Example Answer List: LL7488-1

AnswerCodeScoreAnswer ID
Band 1 (Low)LA37015-7
Band 2 (Mid)LA37016-5
Band 3 (High)LA37017-3

Basic Attributes

Class
CELLMARK
Type
Laboratory
First Released
Version 2.82
Last Updated
Version 2.83 (MIN)
Order vs. Observation
Observation

Language Variants Get Info

TagLanguageTranslation
it-ITItalian (Italy)Valutazione della deformabilità leucocitaria per sepsi:Imp:Pt:Sangue:OrdQn:Citometria.Microfluidica
Synonyms: Ccitometro microfluidico per la deformabilità Impressione/interpretazione di studio Modelli di superficie cellulare Punto nel tempo (episodio) Sangue

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=112301-7