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Part Description

LP266148-8   Measles virus genotype A vaccine strain N gene
The measles virus (MeV) is a single-stranded, enveloped RNA virus and a member of the Paramyxoviridae family. Measles was first discovered to be caused by an infectious agent in 1757 by a Scottish physician. After becoming a notifiable disease in the United States in 1912, there were roughly 6,000 deaths reported each year in the following ten years due to MeV. The vaccination against MeV become available in the United States in 1963 which caused a rapid drop in MeV infections. MeV is highly contagious and is transmitted through infected secretions. Symptoms of infection include fever, malaise, cough, coryza, and conjunctivitis. Later, pathognomonic enanthema (Koplik spots) develop and are followed by a maculopapular rash that appears 14 days after exposure to MeV and spreads from the head, down the trunk, and to the lower extremities. Patients susceptible to serious complications may experience acute encephalitis and subsequent brain damage, fatal respiratory and neurologic complications, or a rare, fatal degenerative disease of the central nervous system characterized by behavioral and intellectual deterioration and seizures that begin 7-10 years after the measles infection. There are 24 genotypes of MeV recognized by the World Health Organization that are categorized by the nucleotide sequences of their hemagglutinin (H) and nucleoprotein (N) genes. The region of the N gene that distinguishes between the genotypes is a 450 nucleotide sequence of the carboxyl terminus referred to as N-450. Sequencing the N-450 region can identify the genotype of the infecting virus. Because infection by MeV vaccine is sometimes given as a post-exposure prophylactic, it has become important to differentiate MeV wild-type infections from the virus present in the vaccine.Vaccine strains all belong to genotype A and the wild-type genotype A MeV strains are believed to no longer be circulating. That being the case, if a patient tests positive for genotype A, then the virus is most likely due to the vaccine.Also, the region of the N gene between nucleotides 478 and 548 is identical for all genotype A vaccine strains that have been analyzed, and PCR-based assays have been developed based on that region so that genotype A vaccine strains can be identified without having to sequence the entire gene.https://www.cdc.gov/measles/hcp/index.htmlhttp://jcm.asm.org/content/55/3/686.full Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Measles virus genotype A vaccine strain N gene:PrThr:Pt:{Specimen}:Ord:{Molgen}
Long Common Name
Measles virus genotype A vaccine strain N gene [Presence] in Specimen by Molgen
Short Name
MeVA vac str N gene Spec Ql
Display Name
MeV genotype A vaccine strain N gene Molgen Ql (Specimen)
Consumer Name Alpha Get Info
Measles virus Genotype A Vaccine Strain N gene, Specimen

Part Model Get Info

  • Component
    Measles virus genotype A vaccine strain N gene
    LP266148-8
    • Analyte
      Measles virus genotype A vaccine strain N gene
      LP266148-8
      • Component Numerator
        Measles virus genotype A vaccine strain N gene
        LP266148-8
        • Component Numerator Core
          Measles virus genotype A vaccine strain N gene
          LP266148-8
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    {Specimen}
    LP451871-0
  • Scale
    Ord
    LP7751-3
  • Method
    {Molgen}
    LP452305-8

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.83
Last Updated
Version 2.83 (ADD)
Order vs. Observation
Both

Member of these Groups Get Info

LOINC GroupGroup Name
LG32756-5Measles virus

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=114855-0