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Part Description

LP262547-5   Clostridium perfringens cpa gene
Clostridium perfringens is a gram positive, anaerobic, rod-shaped bacterium. It is classified into five types designated A through E. Four toxins are produced by C. perfringens that have lethal, necrotic and cytotoxic capabilities. The four toxins are known as alpha-toxin (CPA), beta-toxin (CPB), epsilon-toxin (ETX) and iota-toxin (ITX). PMID: 22069542 When toxins produced by C. perfringens are mixed in different combination, sixteen toxins can be produced. Pathogenesis due to C. perfringens is due almost always to the production of one or more of its toxins. CPA is encoded by the cpa gene that is located on the chromosome and is produced by all strains of C. perfringens. CPA is an enzyme that breaks down phosphatidylcholine and sphingomyelin which damages membrane phospholipids and leads to the lysis of cells. CPA also cause hemolysis, activates the arachidonic cascade and inflammation cascade which induce vasoconstriction. There is no definitive evidence that CPA is involved with enteritis, abomasitis and/or enterotoxemia in cattle, horses, goats, and pigs. In humans, studies support that CPA is the main toxin believed to cause gas gangrene, a disease involving extensive local tissue damage and necrosis that leads to shock and death. Gas gangrene also occurs in domestic animals including sheep, cattle, goats, and horses. PMID: 24511335 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Clostridium perfringens cpa gene:PrThr:Pt:{Specimen}:Ord:{Molgen}
Long Common Name
Clostridium perfringens cpa gene [Presence] in Specimen by Molgen
Short Name
C perfringens cpa Spec Ql
Display Name
C. perfringens cpa gene Molgen Ql (Specimen)
Consumer Name Alpha Get Info
Clostridium perfringens cpa gene, Specimen

Part Model Get Info

  • Component
    Clostridium perfringens cpa gene
    LP262547-5
    • Analyte
      Clostridium perfringens cpa gene
      LP262547-5
      • Component Numerator
        Clostridium perfringens cpa gene
        LP262547-5
        • Component Numerator Core
          Clostridium perfringens cpa gene
          LP262547-5
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    {Specimen}
    LP451871-0
  • Scale
    Ord
    LP7751-3
  • Method
    {Molgen}
    LP452305-8

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.83
Last Updated
Version 2.83 (ADD)
Order vs. Observation
Both

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=115226-3