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Part Description

LP263522-7   Clostridioides difficile BI-NAP1-027 strain
Clostridium difficile (CD) infections in hospitals across the United States, Canada and Europe experienced an enormous increase between 2000 and 2006. The pathogen that was found to cause this outbreak was the strain of CD determined by restriction endonuclease analysis (REA) to be toxin type III, restriction endonuclease analysis (REA) group B1; by pulsed-field gel electrophoresis as North American pulsed-field type NAP1; and by polymerase chain reaction (PCR) ribotyping as type 027. The strain is identified as Clostridium difficile BI/NAP1/027 or NAP1. The NAP1 strain of CD produces increased levels of three toxins, the usual toxins A and B, and a binary toxin. A mutation of the toxin A and B suppressor gene tcdC may explain the increased production of toxin. It is also strongly resistant to treatment with fluoroquinolone antibiotics. CD NAP1 is not a new strain of CD. It was isolated between 1984 and 1992 and is identical to the strain isolated is the 2000s, except that the original CD NAP1 strain was not resistant to the new fluoroquinolone drugs of the time, which included gatifloxacin and moxifloxacin. Risk factors for infection with CD NAP1 include advanced age, hospitalization, and exposure to antibiotics, notably fluoroquinolones and cephalosporins. The elderly are especially vulnerable to infection, and have a 30-day mortality rate of more than 5%. PMID: 19457419 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Clostridioides difficile BI-NAP1-027 strain DNA:PrThr:Pt:{Specimen}:Ord:{Molgen}
Long Common Name
Clostridioides difficile BI-NAP1-027 strain DNA [Presence] in Specimen by Molgen
Short Name
C diff BI NAP1 027 DNA Spec Ql
Display Name
C. difficile BI-NAP1-027 strain DNA Molgen Ql (Specimen)
Consumer Name Alpha Get Info
Clostridioides difficile BI-NAP1-027 strain, Specimen

Part Model Get Info

  • Component
    Clostridioides difficile BI-NAP1-027 strain DNA
    LP263523-5
    • Analyte
      Clostridioides difficile BI-NAP1-027 strain DNA
      LP263523-5
      • Component Numerator
        Clostridioides difficile BI-NAP1-027 strain DNA
        LP263523-5
        • Component Numerator Core
          Clostridioides difficile BI-NAP1-027 strain
          LP263522-7
        • Component Numerator Core Suffix
          DNA
          LP32416-7
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    {Specimen}
    LP451871-0
  • Scale
    Ord
    LP7751-3
  • Method
    {Molgen}
    LP452305-8

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.83
Last Updated
Version 2.83 (ADD)
Order vs. Observation
Both

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=115243-8