Version 2.77

Part Descriptions

LP14377-3   Aldosterone
Aldosterone is a steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland to regulate sodium and potassium balance in the blood. It is synthesized from cholesterol by aldosterone synthase, which is absent in other sections of the adrenal gland. It is the sole endogenous member of the class of mineralocorticoids. Acting on mineralocorticoid receptors (MR) on principal cells in the collecting ducts of the kidneys, it increases the permeability of their apical (luminal) membrane to potassium and sodium and activates their basolateral Na+K+ pumps, stimulating ATP hydrolysis, reabsorbing sodium (Na+) ions and water into the blood, and excreting potassium (K+) ions into the urine. Aldosterone also stimulates H+ secretion by intercalated cells in the collecting duct, regulating plasma bicarbonate (HCO3-) levels and its acidbase balance. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Aldosterone (Wikipedia)

LP14377-3   Aldosterone
Used to detect hyper and hypo aldosteronisnm. Hypoaldosteronism can occur in any condition that causes destruction or dysfunction of the adrenal gland.1,2,4 Hypoaldosterism can be due to primary adrenal insufficiency , congenital adrenal hypoplasia, acquired secondary aldosterone deficiency (hyporeninemic hypoaldosteronism), and acquired Hyporeninemic hypoaldosteronism is the most common form of isolated hypoaldosteronism and is results from impaired renin release from the kidney. Congenital hypoaldosteronism caused by inherited enzymatic defects in aldosterone biosynthesis are rare. Corticosterone methyloxidase I (CMO I) deficiency is associated with elevated serum levels of corticosterone and low levels of 18-hydroxy-corticosterone and aldosterone. Corticosterone methyloxidase II (CMO II) deficiency produces high levels of 18-hydroxy-corticosterone, the immediate precursor of aldosterone.
Acquired primary hypoaldosteronism can be caused by the administration of heparin. Also, persistently hypotensive, critically ill patients with sepsis, pneumonia, peritonitis, cholangitis, and liver failure can have inappropriately low plasma aldosterone concentrations in relation to elevated plasma renin activity. Primary hyperaldosteronism, also referred to as Conn syndrome, is due to overproduction of aldosterone by one or both of the adrenal glands. Some recent studies suggest that 10% to 15% of Hyper thyroidism cases are due to (or associated with ) primary hyperaldosteronism. Secondary hyperaldosteronism is relatively common and can occur as the result of any condition that decreases blood flow to the kidneys (ie, renal artery stenosis), decreases blood pressure, or lowers plasma sodium levels. Secondary hyperaldosteronism may also be seen with cirrhosis, congestive heart failure. and toxemia of pregnancy. Several studies have suggested that high-normal aldosterone levels predict development of high blood pressure in normotensive subjects and that increased aldosterone action contributes to hypertension, cardiovascular fibrosis, and cardiac hypertrophy. Source: Regenstrief Institute

LP32035-5   Creatinine
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. It is transferred to the kidneys by blood plasma, whereupon it is eliminated by glomular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate and measuring its serum level is a simple test. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Creatinine

Fully-Specified Name

Component
Aldosterone/Creatinine
Property
MRto
Time
Pt
System
Urine
Scale
Qn
Method

Additional Names

Short Name
Aldost/Creat Ur
Display Name
Aldosterone/Creatinine (U) [Mass ratio]
Consumer Name Alpha Get Info
Aldosterone/Creatinine, Urine

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 1.0j-a
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
13592

Member of these Groups Get Info

LOINC Group Group Name
LG34671-4 Aldosterone/Creatinine|MRto|Urine

Language Variants Get Info

Tag Language Translation
es-AR Spanish (Argentina) aldosterona/creatinina:relación de concentración de masa:punto en el tiempo:orina:cuantitativo:
es-ES Spanish (Spain) Aldosterona/Creatinina:Relacion de Masa:Punto temporal:Orina:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Aldosterona / Creatinina:Relación de masa:Punto temporal:Orina:Cuantitativo:
et-EE Estonian (Estonia) Aldosteroon/kreatiniin:MRto:Pt:U:Qn:
Synonyms: Juhuslik Kvantitatiivne Uriin
fr-CA French (Canada) Aldostérone/Créatinine:Ratio de masse:Temps ponctuel:Urine:Quantitatif:
fr-FR French (France) Aldostérone/créatinine:Masse ratio:Ponctuel:Urine:Numérique:
fr-BE French (Belgium) Aldostérone/Créatinine:Ratio de masse:Temps ponctuel:Urine:Quantitatif:
Synonyms: Rapport de masse
it-IT Italian (Italy) Aldosterone/Creatinina:MRto:Pt:Urine:Qn:
Synonyms: Chimica Punto nel tempo (episodio) Rapporto di Massa
ko-KR Korean (Korea, Republic Of) 알도스테론/크레아티닌:질량농도비:검사시점:뇨:정량:
nl-NL Dutch (Netherlands) aldosteron/creatinine:massaverhouding:moment:urine:kwantitatief:
Synonyms: kreatinine
pt-BR Portuguese (Brazil) Aldosterona/Creatinina:MCrto:Pt:Urina:Qn:
Synonyms: ; Aldost; Creat; CR; mRto; Mass concentration ratio; Point in time; Random; Ur; UR; Urn; UA; Quantitative; QNT; Quant; Quan; Chemistry; UCr
ru-RU Russian (Russian Federation) Альдостерон/Креатинин:МассОтн:ТчкВрм:Моча:Колич:
Synonyms: Количественный Масс отношение Точка во времени;Момент
tr-TR Turkish (Turkey) Aldosteron/Kreatinin:KütlOr:Zmlı:İdrar:Kant:
zh-CN Chinese (China) 醛固酮/肌酐:质量比率:时间点:尿液:定量型:
Synonyms: CR;Creat;肌氨酸酐;肌酸内酰胺;肌酸酐 UCr 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 尿;小便;下泉 尿液肌酐 尿液肌酸酐 尿肌酸酐 时刻;随机;随意;瞬间 来自于同一体系的两种分析物的质量之比;质量比 肌酸内酰胺 醛基甾酮;醛甾酮;醛皮质酮;醛类脂醇

Example Units

Unit Source
ng/g{creat} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=13482-5