Version 2.77

Part Descriptions

LP14516-6   Isovalerylglycine
Isovalerylglycine is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction: acyl-CoA + glycine < -- > CoA + N-acylglycine Isovalerylglycine is a byproduct of the catabolism of the aminoacid leucine. Accumulation of isovalerylglycine occurs in Isovaleric Acidemia (IVA). IVA (OMIM/ McKusick 243500) is an autosomal recessive disorder caused by mutations in the isovaleryl-CoA dehydrogenase (EC 1.3.99.10) gene. The deficiency of this enzyme in the metabolism of leucine leads to the accumulation of a series of isovaleryl-CoA metabolites, such as isovalerylglycine (IVG). It is very important to caution for false positive results when screening for isovaleric acidemia by tandem mass spectrometry based on dried blood-spot levels of C5-acylcarnitines, including isovalerylcarnitine and its isomer, pivaloylcarnitine; pivaloylcarnitine is derived from pivalate-generating antibiotics, and has caused many false-positive results. PMID: 17850781. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Isovalerylglycine

LP32035-5   Creatinine
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. It is transferred to the kidneys by blood plasma, whereupon it is eliminated by glomular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate and measuring its serum level is a simple test. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Creatinine

Fully-Specified Name

Component
Isovalerylglycine/Creatinine
Property
MRto
Time
Pt
System
Urine
Scale
Qn
Method

Additional Names

Short Name
Isovalerylgly/Creat Ur
Display Name
Isovalerylglycine/Creatinine (U) [Mass ratio]
Consumer Name Alpha Get Info
Isovalerylglycine/Creatinine, Urine

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 1.0k
Last Updated
Version 2.73
Change Reason
This term was Discouraged in a previous release because at the time (2013), this analyte was not being measured in mass units. We are changing the term back to Active status because at least two major laboratories are currently (in 2018) measuring this analyte in mass units.
Order vs. Observation
Observation
Common Test Rank Get Info
7222

Member of these Panels

LOINC Long Common Name
50334-2 Acylglycines panel [Mass Ratio] - Urine

Member of these Groups Get Info

LOINC Group Group Name
LG34610-2 Isovalerylglycine/Creatinine|MRto|Urine

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Isovalerylglycin/Creatinin:Massenverhältnis:Zeitpunkt:Urin:Quantitativ:
es-AR Spanish (Argentina) isovalerilglicina/creatinina:relación de concentración de masa:punto en el tiempo:orina:cuantitativo:
es-ES Spanish (Spain) Isovalerilglicina/Creatinina:Relacion de Masa:Punto temporal:Orina:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Isovalerilglicina / Creatinina:Relación de masa:Punto temporal:Orina:Cuantitativo:
et-EE Estonian (Estonia) Isovalerüülglütsiin/kreatiniin:MRto:Pt:U:Qn:
Synonyms: Juhuslik Kvantitatiivne Uriin
fr-CA French (Canada) Isovalérylglycine/Créatinine:Ratio de masse:Temps ponctuel:Urine:Quantitatif:
fr-BE French (Belgium) Isovalérylglycine/Créatinine:Ratio de masse:Temps ponctuel:Urine:Quantitatif:
Synonyms: Rapport de masse
fr-FR French (France) Isovalérylglycine/créatinine:Masse ratio:Ponctuel:Urine:Numérique:
it-IT Italian (Italy) Isovalerilglicina/Creatinina:MRto:Pt:Urine:Qn:
Synonyms: Chimica Punto nel tempo (episodio) Rapporto di Massa
ko-KR Korean (Korea, Republic Of) 이소발레릴글리신/크레아티닌:질량농도비:검사시점:뇨:정량:
nl-NL Dutch (Netherlands) isovalerylglycine/creatinine:massaverhouding:moment:urine:kwantitatief:
Synonyms: kreatinine
pt-BR Portuguese (Brazil) Isovalerilglicina/Creatinina:MCrto:Pt:Urina:Qn:
Synonyms: ; Isovalerylgly; Creat; CR; mRto; Mass concentration ratio; Point in time; Random; Ur; UR; Urn; UA; Quantitative; QNT; Quant; Quan; Chemistry; UCr
ru-RU Russian (Russian Federation) Изовалерилглицин/Креатинин:МассОтн:ТчкВрм:Моча:Колич:
Synonyms: Количественный Масс отношение Точка во времени;Момент
tr-TR Turkish (Turkey) İzovalerilglisin/Kreatinin:KütlOr:Zmlı:İdrar:Kant:
uk-UA Ukrainian (Ukraine) Ізовалерилгліцин/Креатинін:Масове Співвідношення:МоментЧасу:Сеча:Кількісно:
Synonyms: Chemistry; CR; Crea; Creat; Mass concentration ratio; Mass ratio; MCRto; Point in time; QNT; Quan; Quant; Quantitative; Random; UA; UCr; UR; Urn
zh-CN Chinese (China) 异戊酰甘氨酸/肌酐:质量比率:时间点:尿液:定量型:
Synonyms: CR;Creat;肌氨酸酐;肌酸内酰胺;肌酸酐 UCr 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 尿;小便;下泉 尿液肌酐 尿液肌酸酐 尿肌酸酐 时刻;随机;随意;瞬间 来自于同一体系的两种分析物的质量之比;质量比 肌酸内酰胺

Example Units

Unit Source
mcg/mg cr REGENSTRIEF
mg/gm cr REGENSTRIEF

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=13766-1