13766-1

Isovalerylglycine/Creatinine [Mass Ratio] in Urine

Active

Part Descriptions

LP14516-6   Isovalerylglycine
Isovalerylglycine is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction: acyl-CoA + glycine < -- > CoA + N-acylglycine Isovalerylglycine is a byproduct of the catabolism of the aminoacid leucine. Accumulation of isovalerylglycine occurs in Isovaleric Acidemia (IVA). IVA (OMIM/ McKusick 243500) is an autosomal recessive disorder caused by mutations in the isovaleryl-CoA dehydrogenase (EC 1.3.99.10) gene. The deficiency of this enzyme in the metabolism of leucine leads to the accumulation of a series of isovaleryl-CoA metabolites, such as isovalerylglycine (IVG). It is very important to caution for false positive results when screening for isovaleric acidemia by tandem mass spectrometry based on dried blood-spot levels of C5-acylcarnitines, including isovalerylcarnitine and its isomer, pivaloylcarnitine; pivaloylcarnitine is derived from pivalate-generating antibiotics, and has caused many false-positive results. PMID: 17850781. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Isovalerylglycine

LP32035-5   Creatinine
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. It is transferred to the kidneys by blood plasma, whereupon it is eliminated by glomular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate and measuring its serum level is a simple test. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Creatinine

LOINC Names Get Info

Fully-Specified Name

Isovalerylglycine/Creatinine:MRto:Pt:Urine:Qn:

Long Common Name

Isovalerylglycine/Creatinine [Mass Ratio] in Urine

Short Name

Isovalerylgly/Creat Ur

Display Name

Isovalerylglycine/Creatinine (U) [Mass ratio]

Consumer Name Alpha Get Info

Isovalerylglycine/Creatinine, Urine

Part Model Get Info

• Component

  Isovalerylglycine/Creatinine
  LP286297-9

  • Analyte

    Isovalerylglycine/Creatinine
    LP286297-9

    • Component Numerator

      Isovalerylglycine
      LP14516-6

      • Component Numerator Core

        Isovalerylglycine
        LP14516-6

      • Component Numerator Core Suffix

        NULL
         

    • Component Denominator

      Creatinine
      LP32035-5

      • Component Denominator Core

        Creatinine
        LP32035-5

      • Component Denominator Core Suffix

        NULL
         

  • Challenge

    NULL
     

  • Adjustment

    NULL
     

  • Count

    NULL
     

• Property

  MRto
  LP6834-8

• Time

  Pt
  LP6960-1

  • Time Core

    Pt
    LP6960-1

  • Time Modifier

    NULL
     

• System

  Urine
  LP7681-2

  • System Core

    Urine
    LP7681-2

  • Super System

    NULL
     

• Scale

  Qn
  LP7753-9

• Method

  NULL
   

Basic Attributes

Class

CHEM

Type

Laboratory

First Released

Version 1.0k

Last Updated

Version 2.73 (MIN)

Change Reason

This term was Discouraged in a previous release because at the time (2013), this analyte was not being measured in mass units. We are changing the term back to Active status because at least two major laboratories are currently (in 2018) measuring this analyte in mass units.

Order vs. Observation

Observation

Common Test Rank Get Info

7222

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

• Chemistry
• CR
• Crea
• Creat
• Mass concentration ratio
• Mass ratio
• MCRto
• Point in time
• QNT
• Quan
• Quant
• Quantitative
• Random
• UA
• UCr
• UR
• Urn

Example Units

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CodeSystem lookup

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=13766-1

LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.