13792-7

Phenyllactate/Creatinine [Mass Ratio] in Urine

Discouraged

Status Information

Status

DISCOURAGED

Comment

Most laboratories report this in moles. Double check with your lab for reporting units.

Part Descriptions

LP18451-2   Phenyllactate
L-3-Phenyllactic acid (or PLA) is a chiral aromatic compound involved in phenylalanine metabolism. It is likely produced from phenylpyruvate via the action of lactate dehydrogenase. The D-form of this organic acid is typically derived from bacterial sources while the L-form is almost certainly endogenous. Levels of phenyllactate are normally very low in blood or urine. High levels of PLA in the urine or blood are often indicative of phenylketonuria (PKU) and hyperphenylalaninemia (HPA). PKU is due to lack of the enzyme phenylalanine hydroxylase (PAH), so that phenylalanine is converted not to tyrosine but to phenylpyruvic acid (a precursor of phenylactate). In particular, excessive phenylalanine is typically metabolized into phenylketones through, a transaminase pathway route involving glutamate. Metabolites of this transamination reaction include phenylacetate, phenylpyruvate and phenethylamine. In persons with PKU, dietary phenylalanine either accumulates in the body or some of it is converted to phenylpyruvic acid and then to phenyllactate through the action of lactate dehydrogenase. Individuals with PKU tend to excrete large quantities of phenylpyruvate, phenylacetate and phenyllactate, along with phenylalanine, in their urine. If untreated, mental retardation effects and microcephaly are evident by the first year along with other symptoms which include: unusual irritability, epileptic seizures and skin lesions. Hyperactivity, EEG abnormalities and seizures, and severe learning disabilities are major clinical problems later in life. A "musty or mousy" odor of skin, hair, sweat and urine (due to phenylacetate accumulation); and a tendency to hypopigmentation and eczema are also observed. The neural-development effects of PKU are primarily due to the disruption of neurotransmitter synthesis. In particular, phenylalanine is a large, neutral amino acid which moves across the blood-brain barrier (BBB) via the large neutral amino acid transporter (LNAAT). Excessive phenylalanine in the blood saturates the transporter. Thus, excessive levels of phenylalanine significantly decrease the levels of other LNAAs in the brain. But since these amino acids are required for protein and neurotransmitter synthesis, phenylalanine accumulation disrupts brain development, leading to mental retardation. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Human Metabolome Database

LP32035-5   Creatinine
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. It is transferred to the kidneys by blood plasma, whereupon it is eliminated by glomular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate and measuring its serum level is a simple test. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Creatinine

LOINC Names Get Info

Fully-Specified Name

Phenyllactate/Creatinine:MRto:Pt:Urine:Qn:

Long Common Name

Phenyllactate/Creatinine [Mass Ratio] in Urine

Short Name

Phenyllactate/Creat Ur

Display Name

Phenyllactate/Creatinine (U) [Mass ratio]

Consumer Name Alpha Get Info

Phenyllactate/Creatinine, Urine

Part Model Get Info

• Component

  Phenyllactate/Creatinine
  LP286801-8

  • Analyte

    Phenyllactate/Creatinine
    LP286801-8

    • Component Numerator

      Phenyllactate
      LP18451-2

      • Component Numerator Core

        Phenyllactate
        LP18451-2

      • Component Numerator Core Suffix

        NULL
         

    • Component Denominator

      Creatinine
      LP32035-5

      • Component Denominator Core

        Creatinine
        LP32035-5

      • Component Denominator Core Suffix

        NULL
         

  • Challenge

    NULL
     

  • Adjustment

    NULL
     

  • Count

    NULL
     

• Property

  MRto
  LP6834-8

• Time

  Pt
  LP6960-1

  • Time Core

    Pt
    LP6960-1

  • Time Modifier

    NULL
     

• System

  Urine
  LP7681-2

  • System Core

    Urine
    LP7681-2

  • Super System

    NULL
     

• Scale

  Qn
  LP7753-9

• Method

  NULL
   

Basic Attributes

Class

CHEM

Type

Laboratory

First Released

Version 1.0k

Last Updated

Version 2.44 (MIN)

Order vs. Observation

Both

Language Variants Get Info

Related Names

• Chemistry
• CR
• Crea
• Creat
• Mass concentration ratio
• Mass ratio
• MCRto
• Phenyllactic acid
• Point in time
• QNT
• Quan
• Quant
• Quantitative
• Random
• UA
• UCr
• UR
• Urn

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CodeSystem lookup

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.