13802-4

Pyridinoline/Creatinine [Mass Ratio] in Urine

Discouraged

Status Information

Status

DISCOURAGED

Comment

Most laboratories report this in moles. Double check with your lab for reporting units.

Part Descriptions

LP14914-3   Pyridinoline
Pyridinoline is a fluorescent cross-linking compound of collagen fibers. Crosslinks in collagen and elastin are derived from lysyl and hydroxylysyl residues, a process catalyzed by lysyl oxidase. Fujimoto and colleagues first described the isolation and characterization of a fluorescent material in bovine achilles tendon collagen and termed it pyridinoline. It is reported to be present in collagen of bone and cartilage, but is absent in collagen of skin. It is not present in newly synthesized collagen and is formed from aldimine cross-links during maturation of collagen fibers.

Pyridinoline and deoxypyridinoline were found to be released into the blood during bone degradation and rapidly exereted in the urine. In a preliminary study, both these compounds were proposed as a marker for metastatic bone tumor in patients with prostate cancer. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

LP32035-5   Creatinine
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. It is transferred to the kidneys by blood plasma, whereupon it is eliminated by glomular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate and measuring its serum level is a simple test. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Creatinine

Fully-Specified Name

Component

Pyridinoline/Creatinine

Property

MRto

Time

Pt

System

Urine

Scale

Qn

Method

Additional Names

Short Name

PYD/Creat Ur

Display Name

Pyridinoline/Creatinine (U) [Mass ratio]

Consumer Name Alpha Get Info

Pyridinoline/Creatinine, Urine

Basic Attributes

Class

CHEM

Type

Laboratory

First Released

Version 1.0k

Last Updated

Version 2.44

Order vs. Observation

Both

Member of these Groups Get Info

Language Variants Get Info

Related Names

• Chemistry
• CR
• Crea
• Creat
• Mass concentration ratio
• Mass ratio
• MCRto
• Point in time
• PYD
• Pyr
• Pyridinium collagen crosslinks
• QNT
• Quan
• Quant
• Quantitative
• Random
• UA
• UCr
• UR
• Urn

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CodeSystem lookup

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