14073-1
Phenytoin [Mass/volume] in Saliva (oral fluid)
Active
Part Descriptions
LP14732-9 Phenytoin
An anticonvulsant that is used to treat a wide variety of seizure disorders. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its side effects and interactions with other drugs. [MeSH 2014: Phenytoin]
Source: National Library of Medicine, MeSH 2006,
MeSH: Phenytoin
LP7565-7 Saliva
Saliva is produced primarily by the parotid, submaxillary, and sublingual glands. It is secreted at the rate of 0-3 milliliters per minute which is affected by various factors including anxiety, hydration and hunger. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Oral fluid is used to test a variety of analytes, including to test alcohol, HIV and other antibodies, therapeutic drugs and steroids, but its primary use is to test for drugs of abuse including amphetamines, cocaine and metabolites, opioids, methadone, cannabis and heroin. PMID: 17268583
Source: Regenstrief LOINC
LP262420-5 Saliva DRUG/TOX
Oral fluid (or saliva) is produced primarily by the parotid, submaxillary, and sublingual glands. It is secreted at the rate of 0-3 milliliters per minute which is affected by various factors including anxiety, hydration and hunger. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Oral fluid is used to test a variety of analytes, including to test alcohol, HIV and other antibodies, therapeutic drugs and steroids, but its primary use is to test for drugs of abuse including amphetamines, cocaine and metabolites, opioids, methadone, cannabis and heroin. The test procedures that use oral fluid for drug screening are usually similar to those for other specimens but adapted for oral fluid. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Drugs present in oral fluid are often the parent drug rather than a metabolite and tests kits reflect those differences. Concentrations of cocaine, amphetamines and some opioids in oral fluid are either similar or higher than concentrations in plasma. The concentration of tetrahydrocannabinol (THC) in oral fluid is similar to that of plasma, though in cases where recent ingestion has occurred, levels may be higher due to the significant local absorption in the oral cavity. Confirmatory testing on oral fluid using liquid chromatography-mass spectrometry (LC-MS) is highly sensitive and specific even on relatively small sample sizes. An increased understanding of pharmacokinetics in oral fluid has flourished inover the last ten years has allowed the correlation of . As a result, the concentrations of various drugs in oral fluid have been correlated to blood concentrations and the effects they have on the individual. PMID: 17268583
Source: Regenstrief LOINC
LOINC Names Get Info
- Fully-Specified Name
- Phenytoin:
MCnc: Pt: Saliva: Qn: - Long Common Name
- Phenytoin [Mass/volume] in Saliva (oral fluid)
- Short Name
- Phenytoin Sal-mCnc
- Display Name
- Phenytoin (Sal) [Mass/Vol]
- Consumer Name Alpha Get Info
- Phenytoin, Saliva
Part Model Get Info
Basic Attributes
- Class
- DRUG/TOX
- Type
- Laboratory
- First Released
- Version 1.0k
- Last Updated
- Version 2.70 (MIN)
- Order vs. Observation
- Both
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Fenytoin: |
| de-DE | German (Germany) | Phenytoin: |
| el-GR | Greek (Greece) | Φαινυτοΐνη: Synonyms: DRUG/TOX MCnc Pt Qn Σίελος Φαινυτοΐνη |
| es-AR | Spanish (Argentina) | fenitoína: |
| es-ES | Spanish (Spain) | Fenitoína: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Fenitoína: |
| et-EE | Estonian (Estonia) | Fenütoiin: Synonyms: Juhuslik Kvantitatiivne Sülg |
| fr-CA | French (Canada) | Phénytoïne: |
| fr-FR | French (France) | Diphénylhydantoïne: |
| fr-BE | French (Belgium) | Phénytoïne: |
| it-IT | Italian (Italy) | Fenitoina: Synonyms: Concentrazione di Massa Livelli farmacologici e tossicologia Punto nel tempo (episodio) |
| ko-KR | Korean (Korea, Republic Of) | 페니토인: |
| nl-NL | Dutch (Netherlands) | fenytoïne: |
| pt-BR | Portuguese (Brazil) | Fenitoína: Synonyms: Diphenylhydantoin; |
| ru-RU | Russian (Russian Federation) | Фенитоин: Synonyms: Количественный Массовая концентрация Точка во времени; |
| tr-TR | Turkish (Turkey) | Fenitoin: |
| zh-CN | Chinese (China) | 苯妥英: Synonyms: C15H12N2O2; |
Example Units
| Unit | Source |
|---|---|
| ug/mL | Example UCUM Units |
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