14229-9
P53 protein Ag [Presence] in Tissue by Immune stain
Active
Part Description
LP18603-8 P53 protein
The p53 antigen was first discovered in 1979 and recognized as a tumor repressive gene in 1989. It encodes a protein that monitors the cell cycle by suppressing tumor growth and preventing genome mutation. When p53 is defective, abnormal cell proliferation can occur. Mutations in p53 are present in up to 50% of all human tumors. The three major functions of p53 include growth arrest, DNA repair, and apoptosis. P53 halts the growth arrest function of the cell cycle progress which can activate transcription of proteins that repair DNA. There are low levels of p53 in normal cells, but damage to DNA and similar stress signals may precipitate an increase of p53 protein. Cell death is the final course of action to prevent cells containing abnormal DNA from dividing. The concentration of P53 in cells is probably tightly controlled since high concentrations may accelerate aging due to excess apoptosis.
[http://www.bioinformatics.org/p53/introduction.html] Ongoing studies are investigating the utility of the p53 antibody being used as a biomarker for the early detection of lung cancer in high risk asymptomatic patients. PMID: 21733826
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- P53 protein Ag
- Property
- PrThr
- Time
- Pt
- System
- Tiss
- Scale
- Ord
- Method
- Immune stain
Additional Names
- Short Name
- P53 protein Ag Tiss Ql ImStn
- Display Name
- P53 protein Ag Immune stain Ql (Tiss)
- Consumer Name Alpha Get Info
- P53 protein antigen, Tissue
Basic Attributes
- Class
- PATH
- Type
- Laboratory
- First Released
- Version 1.0k
- Last Updated
- Version 2.73
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 15564
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-AR | Spanish (Argentina) | proteína p53: |
| es-ES | Spanish (Spain) | Proteína p53 Antígeno: |
| es-MX | Spanish (Mexico) | Proteína P53 Ag: |
| et-EE | Estonian (Estonia) | P53 valk antigeen: Synonyms: Järgarvuline Juhuslik Kude |
| fr-CA | French (Canada) | Protéine P53, Ag: |
| fr-FR | French (France) | Protéine P53 antigène: |
| fr-BE | French (Belgium) | Protéine P53 Ag: Synonyms: Antigène Coloration. Méthode mmunologique |
| it-IT | Italian (Italy) | P53, proteina, Ag: Synonyms: Patologia Presenza o Soglia Proteina P53 Punto nel tempo (episodio) Tessuto & |
| ko-KR | Korean (Korea, Republic Of) | P53 단백 항원: |
| nl-NL | Dutch (Netherlands) | p53-eiwit Ag: Synonyms: antigeen |
| pt-BR | Portuguese (Brazil) | P53 Proteína Ag: Synonyms: ; |
| ru-RU | Russian (Russian Federation) | P53 протеин Аг: Synonyms: Белок Порядковый Ткань и мазки Точка во времени; |
| tr-TR | Turkish (Turkey) | P53 protein Ag: Synonyms: Antijen Mevcut |
| zh-CN | Chinese (China) | P53 蛋白 抗原: Synonyms: Ag Oncogene Protein Ag p53 抗癌基因蛋白; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=14229-9
LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright