14670-4
Coproporphyrin 1/Porphyrins.total in Urine
Active
Part Description
LP18633-5 Coproporphyrin 1
Coproporhyrin I is a porphyrin metabolite arising from heme synthesis. Porphyrins are pigments found in both animal and plant life. Coproporphyrin I is a tetrapyrrole dead-end product from the spontaneous oxidation of the methylene bridges of coproporphynogen, arising from heme synthesis and secreted in feces and urine. Increased levels of coproporphyrins can indicate congenital erythropoietic porphyria or sideroblastic anaemia. Porphyria is a pathological state characterised by abnormalities of porphyrin metabolism and results in the excretion of large quantities of porphyrins in the urine and in extreme sensitivity to light. A large number of factors are capable of increasing porphyrin excretion, owing to different and multiple causes and etiologies: 1) the main site of the chronic hepatic porphyria disease process concentrates on the liver, 2) a functional and morphologic liver injury is almost regularly associated with this chronic porphyria, 3) the toxic form due to occupational and environmental exposure takes mainly a subclinical course. Hepatic factors includes disturbance in coproporphyrinogen metabolism, which results from inhibition of coproporphyrinogen oxidase as well as from the rapid loss from, and diminished utilization of coproporphyrinogen in the hepatocytes, which may also explain why coproporphyrin, its autoxidation product, predominates physiologically in the urine; decreased biliary excretion of coproporphyrin leading to a compensatory urinary excretion, so that the coproporphyrin ring isomer ratio (1:III) becomes a sensitive index for impaired liver function and intrahepatic cholestasis; and disturbed activity of hepatic uroporphyrinogen decarboxylase. In itself, secondary coproporphyrinuria is not associated with porphyria symptoms of a hepatologic-gastroenterologic, neurologic, or dermatologic order, even though coproporphyrinuria can occur with such symptoms. PMID: 3327428
Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.)
Source: Human Metabolome Database,
Corproporphyrin I
LOINC Names Get Info
- Fully-Specified Name
- Coproporphyrin 1/Porphyrins.total:
SFr: Pt: Urine: Qn: - Long Common Name
- Coproporphyrin 1/Porphyrins.total in Urine
- Short Name
- Copro1 SFr Ur
- Display Name
- Coproporphyrin 1/Total porphyrins (U) [Molar fraction]
- Consumer Name Alpha Get Info
- Coproporphyrin 1/Total Porphyrins, Urine
Part Model Get Info
- Component
- Coproporphyrin 1/Porphyrins.total
LP285801-9
- Analyte
- Coproporphyrin 1/Porphyrins.total
LP285801-9
- Challenge
- NULL
- Adjustment
- NULL
- Count
- NULL
- Property
- SFr
LP6866-0
- Time
- Pt
LP6960-1
- Time Core
- Pt
LP6960-1
- Time Modifier
- NULL
- System
- Urine
LP7681-2
- System Core
- Urine
LP7681-2
- Super System
- NULL
- Scale
- Qn
LP7753-9
- Method
- NULL
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 1.0k
- Last Updated
- Version 2.70 (MIN)
- Order vs. Observation
- Observation
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Koproporfyrin 1/porfyriny.celkové: |
| de-DE | German (Germany) | Coproporphyrin 1/Porphyrine.gesamt: |
| el-GR | Greek (Greece) | Κοπροπορφυρίνη 1/Πορφυρίνες.ολικές: Synonyms: CHEM Pt Qn SFr Κοπροπορφυρίνη Κοπροπορφυρίνη 1 Ούρα Πορφυρίνες Πορφυρίνες.ολικές |
| es-MX | Spanish (Mexico) | Coproporfirina 1 / Porfirinas total: |
| es-AR | Spanish (Argentina) | coproporfirina 1/porfirinas.totales: |
| es-ES | Spanish (Spain) | Coproporfirina 1/Niveles totales de porfirinas: Synonyms: Cuantitativo |
| et-EE | Estonian (Estonia) | Koproporfüriin 1/porfüriinid.üld: Synonyms: Aine fraktsioon Juhuslik Kvantitatiivne Uriin |
| fr-CA | French (Canada) | Coproporphyrine 1/Porphyrines.totales: |
| fr-FR | French (France) | Coproporphyrine 1/porphyrines totales: |
| fr-BE | French (Belgium) | Coproporphyrine 1/Porphyrines.totales: Synonyms: Fraction. Concentration |
| it-IT | Italian (Italy) | Coproporfirina 1/Porfirine.totali: Synonyms: Chimica Frazione di Sostanza Punto nel tempo (episodio) |
| ko-KR | Korean (Korea, Republic Of) | 코프로포르피린 1/총포르피린: |
| nl-NL | Dutch (Netherlands) | coproporfyrine 1/porfyrinen.totaal: |
| pt-BR | Portuguese (Brazil) | Coproporfirina 1/Porfirinas.total: Synonyms: ; |
| ru-RU | Russian (Russian Federation) | Копропорфирин 1/Порфирины.общий: Synonyms: Количественный Мольная доля; |
| tr-TR | Turkish (Turkey) | Koproporfirin 1/Porfirinler.total: |
| zh-CN | Chinese (China) | 粪卟啉 I/卟啉.总计: Synonyms: Ⅰ Copro; |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
LOINC Copyright
Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://