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Term Description

Identifies an evening specimen when cortisol is at its lowest point in a circadian cycle -often considered to be midnight. Some laboratories will call this "12AM (midnight)" specimen, but specimens in the range of 11PM to 1AM are acceptable. The trough time may have to be adjusted for patients on different work shifts because their circadian rhythms can shift with their sleeping time.

Part Descriptions

LP14161-1   Cortisol
Cortisol is a glucocorticoid produced in the adrenal cortex. A synthetic version of this same chemical is called hydrocortisone and manufactured as medication. Cortisol is not to be confused with cortisone, a closely related compound with much less (PubChem calls it "inactive") biologic activity. Cortisone is also offered as a drug, and it is converted to cortisol (the active form) in the liver. They both have a circadian rhythm with peak in the AM (around 8AM) and trough in the evening (around midnight), but this shifts according to sleep habits (work shifts). The morning measurement, which should be high, is most useful for diagnosing Addison's disease (too little cortisol) and the evening measurement, which should be low, is the most useful for diagnosing Cushing's disease (too much cortisol). Salivary cortisol may be a more sensitive measure than serum or plasma. Source: Regenstrief Help

LP156504-5   PM trough specimen
Identifies an evening specimen when analyte is at its lowest point in a circadian cycle -often considered to be midnight. Some laboratories will call this "12AM (midnight)" specimen, but specimens in the range of 11PM to 1AM are acceptable. The trough time may have to be adjusted for patients on different work shifts because their circadian rhythms can shift with their sleeping time. Source: Regenstrief Help

LOINC Names Get Info

Fully-Specified Name
Cortisol^PM trough specimen:SCnc:Pt:Ser/Plas:Qn:
Long Common Name
Cortisol [Moles/volume] in Serum or Plasma --PM trough specimen
Short Name
Cortis PM SerPl-sCnc
Display Name
Cortisol PM trough specimen [Moles/Vol]
Consumer Name Alpha Get Info
Cortisol PM Trough specimen, Blood

Part Model Get Info

  • Component
    Cortisol^PM trough specimen
    LP307396-4
    • Analyte
      Cortisol
      LP14161-1
      • Component Numerator
        Cortisol
        LP14161-1
        • Component Numerator Core
          Cortisol
          LP14161-1
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      PM trough specimen
      LP156504-5
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    SCnc
    LP6860-3
  • Time
    Pt
    LP6960-1
  • System
    Ser/Plas
    LP7576-4
    • System Core
      Ser/Plas
      LP7576-4
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    NULL
     

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 1.0k
Last Updated
Version 2.73 (MIN)
Change Reason
To avoid two ways (PM and evening) of saying the same thing. We chose PM because it is shorter. 'Trough' clarifies that specimen is collected when cortisol is expected to be at the lowest level.
Order vs. Observation
Both

Member of these Panels

LOINCLong Common Name
79221-8Steroid fractions panel - Serum or Plasma

Member of these Groups Get Info

LOINC GroupGroup Name
LG50773-7Cortisol^PM trough specimen|Pt|Ser/Plas

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Kortizol^Vzorek z odpoledního minima:Látková koncentrace:Časový bod:Sérum/plazma:Kvantitativní:
el-GRGreek (Greece)Κορτιζόλη^Δείγμα κατωφλίου μ.μ.:SCnc:Pt:Ορός/Πλάσμα:Qn:
Synonyms: CHEM Pt Qn SCnc Δείγμα κατωφλίου μ.μ. ελάχιστα επίπεδα Κορτιζόλη Ορός Ορός/Πλάσμα Πλάσμα
es-ARSpanish (Argentina)cortisol^vespertino:concentración de sustancia:punto en el tiempo:suero/plasma:cuantitativo:
es-ESSpanish (Spain)Cortisol^PM muestra valle:Concentración de sustancia:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Cortisol ^ PM a través de la muestra:Concentración de sustancias:Punto temporal:Suero o Plasma:Cuantitativo:
fr-CAFrench (Canada)Cortisol^Spécimen creux PM:Concentration de substance:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-FRFrench (France)Cortisol^résiduel Soir:Moles/Volume:Ponctuel:Sérum/Plasma:Numérique:
fr-BEFrench (Belgium)Cortisol^Spécimen PM minimal:Concentration de substance:Temps ponctuel:Sérum/Plasma:Quantitatif:
Synonyms: Echantillon. PM.minimal Minimum, nadir
it-ITItalian (Italy)Cortisolo^campione minimo serale:SCnc:Pt:Siero/Plasma:Qn:
Synonyms: Chimica Concentrazione di Sostanza Plasma Punto nel tempo (episodio) Siero Siero o Plasma valore minimo TDM
ko-KRKorean (Korea, Republic Of)코티솔^저녁:물질농도:검사시점:혈청/혈장:정량:
nl-NLDutch (Netherlands)cortisol^middag-dalspiegelmonster:mol/volume:moment:serum of plasma:kwantitatief:
pt-BRPortuguese (Brazil)Cortisol^amostra noturna:SCnc:Pt:Sor/Plas:Qn:
Synonyms: ; Cortis; Coritsol; Compound F; 17-Hydroxycorticosterone; PM; Substance concentration; Level; Point in time; Random; SerPl; SerPlas; SerP; Serum; SR; Plasma; Pl; Plsm; Quantitative; QNT; Quant; Quan; Spec; Chemistry
ru-RURussian (Russian Federation)Кортизол^Вечерний минимальный образец:МолКонц:ТчкВрм:Сыв/Плаз:Колич:
Synonyms: Количественный минимум концентрации Молярность;Молярная объёмная концентрация Плазма Провал концетрации кортизола наблюдающийся с 23:00 до 1:00 Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TRTurkish (Turkey)Kortizol^Öğleden sonra örneği:SubKons:Zmlı:Ser/Plaz:Kant:
Synonyms: çukur düzey
uk-UAUkrainian (Ukraine)Кортизол^вечірній мінімальний зразок:Молярна Концентрація:МоментЧасу:Сироватка/Плазма:Кількісно:
Synonyms: 12 AM; 12AM; 17-Hydroxycorticosterone; Chemistry; circadian low; Compound F; Coritsol; Cort; Evening; F; hydrocortisone; late night specimen; Level; Midnight; Pl; Plasma; Plsm; PM diurnal trough; Point in time; Pre; Predose; Pre-dose; QNT; Quan; Quant; Quantitative; Random; SerP; SerPl; SerPlas; Serum; Serum or plasma; Spec; SR; Substance concentration
zh-CNChinese (China)皮质醇^晚上波谷标本:物质的量浓度:时间点:血清/血浆:定量型:
Synonyms: 17-羟皮质甾酮;17-羟皮质酮;化合物 F;可的索;氢化可的松;皮质甾醇;考的索 一剂药物的初始剂量;初始剂量;剂量药物的初始剂量;前剂量;曲线上的最小值;最低点;本底剂量;治疗药物监测 - 波谷;预剂量 克分子浓度;克分子浓度(单位体积);摩尔浓度;摩尔浓度(单位体积);物质的量浓度(单位体积) 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 受检物 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 晚上（晚间）波谷（谷值、低谷、最小值、最低点）标本（样本、样品、试样） 标本（样本、样品、试样） 样品 样本 血清或血浆 试样

Example Units

UnitSource
nmol/LExample UCUM Units
nmol/LeCHN

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=14678-7