LOINC
Version 2.69

14804-9Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reactionActive

Part Descriptions

LP15033-1   Lactate dehydrogenase
Lactate dehydrogenase (LDH) is an enzyme (EC 1.1.1.27) present in a wide variety of organisms, including plants and animals. It catalyses the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+. As it can also catalyze the oxidation of hydroxybutyrate, it is occasionally called hydroxybutyrate dehydrogenase (HBD). Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, D-lactate (Wikipedia)

LP15033-1   Lactate dehydrogenase
Lactate dehydrogenase (LDH, or also called LD) is an oxidoreductase (LD: EC 1.1.1.27) and is the most important clinically of several dehydrogenases occurring in human serum. LDH catalyses the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD. When disease, injury, or toxic material damages tissues, cells release LDH into the bloodstream. Since LDH is a fairly stable enzyme, it has been widely used to evaluate the presence of damage and toxicity of tissue and cells. LDH is cytoplasmic in its cellular location and in any one tissue is composed of one or two of five possible isoenzymes. While many of its clinical applications involve quantification of one or more specific serum isoenzymes, an estimate of total LDH is usually required. Lactate dehydrogenase catalyzes the reversible reaction: L-lactate + NAD <--> pyruvate + NADH. Testing methods either measure the increase in NADH produced in the lactate-to-pyruvate reaction or the decrease in NADH produced in the pyruvate-to-lactate reaction. [PMID: 3882046] . Reference ranges are highly method dependent. The pyruvate-to-lactate reaction is preferred theoretically because the equilibrium constant is large and the rate for any amount of enzyme is 2-3 times faster, thus smaller sample and shorter observation periods are needed. Disadvantages of the pyruvate-to-lactate reaction are loss of linearity as compared with the lactate-to-pyruvate reaction, and greater substrate inhibition of the enzyme. [Tietz Fourth Edition] Source: Regenstrief LOINC

Fully-Specified Name

Component
Lactate dehydrogenase
Property
CCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method
Reaction: lactate to pyruvate

Additional Names

Short Name
LDH SerPl L to P-cCnc
Display Name
LDH Lactate to pyruvate reaction [Catalytic activity/Vol]
Consumer Name Alpha
Lactate Dehydrogenase (LDH), Blood

Associated Observations

This panel contains a collection of ask-at-order entry questions and associated observations that may be included within various PhenX protocols for biomarker testing. Each protocol varies as to the items asked & recorded, so not all terms will be used but are displayed together for users to find the appropriate LOINCs.

LOINC Name R/O/C Cardinality Example UCUM Units
95405-7 Assay related variables panel
Indent30525-0 Age a
Indent46098-0 Sex
Indent66165-2 Last ate or drank anything other than plain water [Date and time]
Indent80331-2 Date and time of last void {clock_time}
Indent66177-7 Do you have hemophilia?
Indent94741-6 Cancer chemotherapy received in the past 4W
Indent66178-5 Have you received cancer chemotherapy in the past four weeks or do you anticipate such therapy in the next four weeks?
Indent66504-2 Exclusion Criteria
Indent41395-5 Collection date of Urine
Indent74751-9 Collection time of Urine {clock_time}
Indent94331-6 Specimen Collection procedure comment
Indent95044-4 Patient refused specimen collection
Indent94846-3 History of Specimen collection problem
Indent94847-1 Reason specimen not collected
Indent77301-0 Reason care action performed or not
Indent66180-1 Was blood drawn?
Indent66181-9 Was full sample obtained?
Indent94330-8 Specimen Processing comment
Indent8251-1 Service comment
Indent85069-3 Lab test method [Type]
Indent66200-7 Repeatability of the assay {ratio}
Indent66201-5 Coefficient of variation for the assay {CV}
Indent66208-0 Make of the equipment used to perform...
Indent74719-6 Manufacturer of the equipment used
Indent74720-4 Device name

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 1.0k
Last Updated
Version 2.68
Order vs. Observation
Both

Reference Information

Type Source Reference
Webcontent Lab Tests Online®Copyright Copyright © 2001-2019 American Association for Clinical Chemistry Lactate Dehydrogenase (LD)

Member of these Panels

LOINC Long Common Name
42929-0 Lactate dehydrogenase panel - Serum or Plasma

Language Variants Get Info

zh-CNChinese (China)
乳酸脱氢酶:催化浓度:时间点:血清/血浆:定量型:反应: 乳酸至丙酮酸
nl-NLDutch (Netherlands)
lactaatdehydrogenase:enzymatische activiteit/volume:moment:serum of plasma:kwantitatief:reactie: lactaat naar pyruvaat
fr-BEFrench (Belgium)
Lactate déshydrogénase:Concentration catalytique:Temps ponctuel:Sérum/Plasma:Quantitatif:Réaction: lactate en pyruvate
fr-CAFrench (Canada)
Lactate déshydrogénase:Concentration catalytique:Temps ponctuel:Sérum/Plasma:Quantitatif:Réaction: lactate en pyruvate
fr-FRFrench (France)
Lactate déhydrogénase:Catalytique/Volume:Ponctuel:Sérum/Plasma:Numérique:Réaction : Lactate vers Pyruvate
de-DEGerman (Germany)
Lactatdehydrogenase:KKnz:Pkt:Ser/Plas:Qn:Reaktion: Lactat zu Pyruvat
it-ITItalian (Italy)
Lattato deidrogenasi:CCnC:Pt:Siero/Plasma:Qn:Reazione: lattato in piruvato
ko-KRKorean (Korea, Republic of)
젖산 탈수소효소:촉매농도:검사시점:혈청/혈장:정량 :반응:젖산에서에서 피루브산염 반응:
pt-BRPortuguese (Brazil)
Desidrogenase Láctica:CCnc:Pt:Sor/Plas:Qn:Reação de lactato a piruvato
es-ARSpanish (Argentina)
lactato deshidrogenasa:concentración catalítica:punto en el tiempo:suero/plasma:cuantitativo:reacción: lactato a piruvato
es-ESSpanish (Spain)
Lactato deshidrogenasa:Concentración Catalítica:Punto temporal:Suero o Plasma:Qn:Reacción - lactato piruvato
tr-TRTurkish (Turkey)
Laktat dehidrojenaz:KtlKons:Zmlı:Ser/Plaz:Kant:Reaksiyon: laktat tan piruvat a

Example Units

Unit Source
U/L Example UCUM Units

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=14804-9