15210-8
Thyroglobulin Ab [Presence] in Serum
Active
Part Descriptions
LP14697-4 Thyroglobulin
Thyroglobulin (Tg) is a protein produced by and used entirely within the thyroid gland. Thyroglobulin is used by the thyroid gland to produce the thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is stored in the thyroid in follicle cysts surrounded by colloid cells. Via a reaction with the enzyme thyroperoxidase, iodine is covalently bound to tyrosine residues in thyroglobulin molecules, forming monoiodotyrosine (MIT) and diiodotyrosine (DIT). Thyroxine is produced by linking two moieties of DIT. Combining one particle of MIT and one particle of DIT produces triiodothyronine. Proteases in lysosomes digest iodinated thyroglobulin, releasing T3 and T4. Thyroglobulin levels in the blood can be used as a tumor marker for certain kinds of thyroid cancer. Thyroglobulin levels in the blood can also be elevated in cases of Graves Disease.
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Source: Wikipedia,
Thyroglobulin (Wikipedia)
LP14697-4 Thyroglobulin
Thyroglobulin (Tg) is a glycoprotein homodimer produced by the thyroid gland. It is important in the synthesis of thyroxine and triiodothyronine, and is where the inactive forms of thyroid hormone and iodine are stored. Mutations in the Tg gene cause thyroid dyshormonogenesis resulting in goiter, and can be associated with moderate to severe congenital hypothyroidism. Polymorphisms in the Tg gene are associated with susceptibility to autoimmune thyroid diseases such as Graves disease or Hashimoto thyroiditis. [NCBI Gene ID:7038] Tg is an established tumor marker used in the diagnosis of differentiated thyroid carcinoma. PMID: 9543128
Source: Regenstrief LOINC
LP39996-1 Thyroglobulin Ab
Circulating immunoglobulins directed against thyroglobulin are commonly present in patients with autoimmune (Hashimoto) thyroiditis and, to a lesser extent, Graves disease. Thyroglobulin is a 660-kd protein precursor of thyroid hormones. Thyroglobulin antibodies are present in the sera of approximately 70% of patients with autoimmune thyroiditis. The principal use of the test is to confirm that a patient's diffuse goiter and/or hypothyroidism is due to autoimmune thyroiditis. The test may also help distinguish Graves disease from toxic nodular goiter. Although thyroglobulin antibodies are present less often than thyroid microsomal antibodies (eg, thyroid peroxidase antibodies, anti-TPO) in patients with autoimmune thyroid diseases, screening fro both immunoglobulins increases diagnostic sensitivity. Thyroglobulin antibodies may be detected in individuals without clinically significant thyroid disease. They do not define the patient's thyroid functional status.
Source: Quest Diagnostics Inc.,
Thyroglobulin antibodies
LOINC Names Get Info
- Fully-Specified Name
- Thyroglobulin Ab:
PrThr: Pt: Ser: Ord: - Long Common Name
- Thyroglobulin Ab [Presence] in Serum
- Short Name
- Thyroglob Ab Ser Ql
- Display Name
- Thyroglobulin Ab Ql (S)
- Consumer Name Alpha Get Info
- Thyroglobulin antibody, Blood
Part Model Get Info
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 1.0k
- Last Updated
- Version 2.73 (MIN)
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 2677
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Tyreoglobulin Ab: |
| el-GR | Greek (Greece) | Θυρεοσφαιρίνη Αντίσωμα: Synonyms: Ord PrThr Pt SERO Αντίσωμα Θυρεοσφαιρίνη Ορός |
| es-AR | Spanish (Argentina) | [anticuerpo anti - ] tiroglobulina [Ac]: |
| es-ES | Spanish (Spain) | Tiroglobulina Anticuerpos: |
| es-MX | Spanish (Mexico) | Tiroglobulina Ab: |
| et-EE | Estonian (Estonia) | Türeoglobuliin antikehad: Synonyms: Järgarvuline Juhuslik Seerum |
| fr-CA | French (Canada) | Thyroglobuline, Ac: |
| fr-FR | French (France) | Thyroglobuline Ac: |
| fr-BE | French (Belgium) | Thyroglobuline Ac: Synonyms: Anticorps hTG |
| it-IT | Italian (Italy) | Tireoglobulina Ab: Synonyms: anticorpo Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant |
| ko-KR | Korean (Korea, Republic Of) | 갑상샘글로불린 항체: |
| nl-NL | Dutch (Netherlands) | thyreoglobuline As: Synonyms: antistof; |
| pl-PL | Polish (Poland) | Tyreoglobulina Ab: |
| pt-BR | Portuguese (Brazil) | Tireoglobulina Ac: Synonyms: AntiTiroglob; |
| ru-RU | Russian (Russian Federation) | Тиреоглобулин Ат: Synonyms: Антитело Порядковый Сыворотка Точка во времени; |
| tr-TR | Turkish (Turkey) | Tiroglobulin Ab: Synonyms: Ak Mevcut |
| uk-UA | Ukrainian (Ukraine) | Тиреоглобулін Антитіла: Synonyms: ABS; |
| zh-CN | Chinese (China) | 甲状腺球蛋白 抗体: Synonyms: Ab; |
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LOINC Copyright
Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://