Version 2.77

Part Description

LP16758-2   SCL-70 extractable nuclear
Topoisomerase I (also known as Scl-70) is a nuclear enzyme that plays a role in releasing tension that is introduced in double-stranded DNA during DNA replication by transiently cleaving and rejoining one strand of the DNA duplex. Anti-Scl-70 autoantibodies are a marker of systemic sclerosis as well as other autoimmune diseases, including systemic lupus erythematosus (SLE). In patients with systemic sclerosis, anti-SCL-70 may be associated with more severe disease, and in patients with SLE, anti-SCL-70 suggests an increased risk of pulmonary hypertension and renal involvement. In general, anti-SCL-70 antibody status may help with diagnosis, treatment planning and prognosis in patients with connective tissue disease. PMID: 11229469 Source: Regenstrief LOINC, PMID: 11229469

Fully-Specified Name

Component
SCL-70 extractable nuclear Ab.IgG
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method
IA

Additional Names

Short Name
ENA Scl70 IgG Ser Ql IA
Display Name
SCL-70 extractable nuclear IgG IA Ql (S)
Consumer Name Alpha Get Info
SCL-70 extractable nuclear IgG antibody, Blood

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 1.0l
Last Updated
Version 2.73
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both
Common Test Rank Get Info
13114

Member of these Panels

LOINC Long Common Name
85092-5 Liver diseases autoimmune IgG panel - Serum or Plasma by Line blot

Member of these Groups Get Info

LOINC Group Group Name
LG5142-7 SCL-70 extractable nuclear Ab.IgG|PrThr|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: Scl-70 IgG-AK ql.
es-AR Spanish (Argentina) SCL-70 nuclear extraíble:concentración arbitraria:punto en el tiempo:suero:ordinal:enzimoinmunoanálisis
es-ES Spanish (Spain) Antígeno nuclear extraíble SCL-70 IgG:PrThr:Punto temporal:Suero:Ord:IA
es-MX Spanish (Mexico) Ab.IgG nuclear extraíble SCL-70:Presencia o umbral:Punto temporal:Suero:Ordinal:Inmunoensayo
fr-CA French (Canada) SCL-70 nucléaire soluble , IgG:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:IA
fr-FR French (France) SCL-70 anticorps IgG:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Immunoanalyse
fr-BE French (Belgium) SCL-70 nucléaire soluble Anticorps. IgG:PrThr:Temps ponctuel:Sérum:Ordinal:IA
Synonyms: Anticorps
it-IT Italian (Italy) Nucleare estraibile SCL-70 Ab.IgG:PrThr:Pt:Siero:Ord:IA
Synonyms: anticorpi IgG anticorpo ENA Immunoassay Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
ko-KR Korean (Korea, Republic Of) SCL-70 추출성 핵 항체.면역글로불린 G:임의농도:검사시점:혈청:순위척도:효소면역측정법
nl-NL Dutch (Netherlands) SCL-70 extraheerbare nucleaire As.IgG:aanwezigheid:moment:serum:ordinaal:immunoassay
Synonyms: antistof; antilichaam IA
pl-PL Polish (Poland) SCL-70 rozpuszczalny jądrowy Ab.IgG:granica wykrywalności:punkt w czasie:surowica:półilościowy:metoda immunologiczna
Synonyms: IgG Przeciwciała do rozpuszczalnego antygenu jądrowego Przeciwciała IgG do jądra komórkowego Przeciwciała przeciwjądrowe SCL-70 rozpuszczalny jądrowy
pt-BR Portuguese (Brazil) SCL-70 Ac.IgG:ACnc:Pt:Soro:Ord:Imunoensaio
Synonyms: ; ENA Scl70; Scleroderma Ac; ANA; ANF; NA; Antinuclear antibody; Nuc; Immune globulin G; Immunoglobulin G; Arbitrary concentration; Point in time; Random; Serum; SR; Ql; Ordinal; QL; Qualitative; Qual; Screen; Enzyme immunoassay; ELISA; MEIA; SUDS; ELFA; IAA; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; Serology
ru-RU Russian (Russian Federation) SCL-70 экстрагируемый ядерный Ат.IgG:PrThr:ТчкВрм:Сыв:Пор:IA
Synonyms: Антитело Порядковый Сыворотка Точка во времени;Момент
tr-TR Turkish (Turkey) SCL-70 özütlenebilir nükleer Ab.IgG:MevcEşik:Zmlı:Ser:Srl:İA
Synonyms: Ak Ak.IgG Çekirdek İmmünölçüm, immünoassay Mevcut
zh-CN Chinese (China) SCL-70 可提取性核 抗体.IgG:存在情况或阈值:时间点:血清:序数型:免疫测定法
Synonyms: Ab.IgG;IgG;抗体 IgG Ab;自身抗体 ANA ENA Ab ENA SCL-70 Ab ENA SCL-70 Ab.IgG ENA SCL-70 IgG ENA SCL-70 抗体 ENA SCL-70 抗体.IgG ENA SCL-70;SCL-70 可提取性核 Ag;SCL-70 可提取性核抗原;可提取性核抗原 SCL-70;皮硬化症 Ab;皮硬化症抗体;硬皮病 Ab;硬皮病抗体;硬皮症 Ab;硬皮症抗体 ENA 抗体 ENA;可提取性核 Ag;可提取性核抗原;可提取性核抗原（Extractable Nuclear Antigen，ENA）;可提取性细胞核;可提取性细胞核 Ag;可提取性细胞核抗原;盐水可提取性核 Ag;盐水可提取性核抗原;盐水可提取性细胞核 Ag;盐水可提取性细胞核抗原 NA SCL-70 可提取性核 Ab SCL-70 可提取性核 Ab.IgG SCL-70 可提取性核 Ag Ab SCL-70 可提取性核 Ag Ab.IgG SCL-70 可提取性核抗原抗体 SCL-70 可提取性核抗原抗体.IgG 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验 免疫球蛋白 G 可提取性核 Ab 可提取性核 Ag 之 Ab 可提取性核抗原 SCL-70 Ab 可提取性核抗原 SCL-70 Ab.IgG 可提取性核抗原 SCL-70 IgG 可提取性核抗原 SCL-70 抗体 可提取性核抗原 SCL-70 抗体.IgG 可提取性核抗原之抗体 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 抗 ENA 抗可提取性核 Ag 抗可提取性核抗原 抗核 Ab 抗核抗体 抗核抗体（Antinuclear antibody，ANA） 时刻;随机;随意;瞬间 核;胞核 核心抗体IgG 核心抗原抗体.IgG 核心抗原抗体IgG 核抗体.IgG 核抗体IgG 核抗原抗体.IgG 核抗原抗体IgG 皮硬化症 硬皮病 硬皮病（Scleroderma，SCL） 硬皮症 细胞核 Ab 细胞核 Ab.IgG 细胞核 IgG 胞核 Ab 胞核 Ab.IgG 胞核抗体 胞核抗体.IgG 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=17570-3