LP16758-2
SCL-70 extractable nuclear
Active
Description
Topoisomerase I (also known as Scl-70) is a nuclear enzyme that plays a role in releasing tension that is introduced in double-stranded DNA during DNA replication by transiently cleaving and rejoining one strand of the DNA duplex. Anti-Scl-70 autoantibodies are a marker of systemic sclerosis as well as other autoimmune diseases, including systemic lupus erythematosus (SLE). In patients with systemic sclerosis, anti-SCL-70 may be associated with more severe disease, and in patients with SLE, anti-SCL-70 suggests an increased risk of pulmonary hypertension and renal involvement. In general, anti-SCL-70 antibody status may help with diagnosis, treatment planning and prognosis in patients with connective tissue disease. PMID: 11229469 Source: Regenstrief LOINC, PMID: 11229469
Basic Part Properties
- Part Name
- SCL-70 extractable nuclear
- Part Display Name
- SCL-70 extractable nuclear
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- ENA Scl70
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | SCL-70 可提取性核 Synonyms: ENA SCL-70; |
| fr-CA | French (Canada) | SCL-70 nucléaire soluble |
| es-ES | Spanish (Spain) | Antígeno nuclear extraíble SCL-70 |
| it-IT | Italian (Italy) | Nucleare estraibile SCL-70 |
| tr-TR | Turkish (Turkey) | SCL-70 özütlenebilir nükleer |
| ru-RU | Russian (Russian Federation) | SCL-70 экстрагируемый ядерный |
| nl-NL | Dutch (Netherlands) | SCL-70 extraheerbare nucleaire |
| fr-BE | French (Belgium) | SCL-70 nucléaire soluble |
| fr-FR | French (France) | SCL-70 |
| pl-PL | Polish (Poland) | SCL-70 rozpuszczalny jądrowy Synonyms: SCL-70 rozpuszczalny jądrowy |
| el-GR | Greek (Greece) | Εκχυλίσιμα πυρηνικά SCL-70 Synonyms: Εκχυλίσιμα πυρηνικά SCL-70 |
LOINC Copyright
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