18299-8

IgA [Presence] in Serum by Immunofixation

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Part Descriptions

LP14669-3   IgA
Immunoglobulin A (IgA) is a glycoprotein that plays a critical role in mucosal immunity. More IgA is produced in mucosal linings than all other immunoglobulins (IgG,IgM,IgE), combined; between 3 and 5g are secreted into the intestinal lumen each day. IgA, in its secretory form, is the main immunoglobulin found in mucous secretions, including tears, saliva, colostrum, intestinal juice, vaginal fluid and secretions from the prostate and respiratory epithelium. It is also found in small amounts in blood. Because it is resistant to degradation by enzymes, secretory IgA can survive in harsh environments such as the digestive and respiratory tracts, thus providing a first line of defense against pathogens that multiply in body secretions. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, IgA

LP6336-4   Immunofixation
Plasma or concentrated urine is deposited on a gel. With an electrical current the proteins are sorted in function of their size, after which antigens for each targeted type of immunoglobulin are deposited on the gel. Thus more or less narrow bands appear on the gel, marking the location of the various immunoglobulines.
Immunofixation tends to replace protein electrophoresis because:

• it is faster (results within three hours);
• it is somewhat more sensitive. Immunofixation may reveal an immunoglobulin missed out by protein electrophoresis, especially at low concentrations (less than 1 gram/litre);
• it can be partially automated and can be used in more laboratories;
• it is more easily read and interpreted.

Immunofixation is however only sensitive to immunoglobulins and is more expensive than protein electrophoresis. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Immunofixation

Reference Information

Fully-Specified Name

Component

IgA

Property

PrThr

Time

Pt

System

Ser

Scale

Ord

Method

Immunofixation

Additional Names

Short Name

IgA Ser Ql IFE

Display Name

IgA Immunofixation Ql (S)

Consumer Name Alpha Get Info

IgA, Blood

Basic Attributes

Class

CHEM

Type

Laboratory

First Released

Version 1.0l

Last Updated

Version 2.73

Change Reason

The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.

Order vs. Observation

Observation

Common Test Rank Get Info

14266

Member of these Groups Get Info

Language Variants Get Info

Related Names

• Chemistry
• IFE
• Ifix
• Immune globulin A
• Immunofixation electrophoresis
• Immunoglobulin A
• Ordinal
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• Screen
• Serum
• SR

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CodeSystem lookup

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Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2024, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.