Version 2.78

Part Description

LP229750-7   t(2;5)(p23;q35.1)(ALK,NPM1) fusion transcript
The ALK gene encodes for the protein anaplastic lymphoma kinase (ALK) (also known as ALK tyrosine kinase receptor or CD246), and the NPM1 gene encodes for the protein nucleophosmin (also known as nucleolar phosphoprotein B23 or numatrin). PMID: 29455642 The 2;5 chromosomal translocation is associated with approximately 60% anaplastic large-cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2 and coding for the catalytic domain, is fused to the 5' portion of NPM from chromosome 5. The product of the NPM-ALK fusion gene is oncogenic. PMID: 17519389 Source: Regenstrief LOINC

Fully-Specified Name

Component
t(2;5)(p23;q35.1)(ALK,NPM1) fusion transcript
Property
Arb
Time
Pt
System
Bld/Tiss
Scale
Ord
Method
Molgen

Additional Names

Long Common Name
t(2;5)(p23;q35.1)(ALK,NPM1) fusion transcript [Presence] in Blood or Tissue by Molecular genetics method
Short Name
t(2;5)(ALK,NPM1) Bld/T Ql
Display Name
t(2;5)(p23;q35.1)(ALK,NPM1) fusion transcript Molgen Ql (Bld/Tiss)
Consumer Name Alpha Get Info
t(2;5)(p23;q35.1)(ALK,NPM1) fusion transcript analysis, Blood or tissue specimen

Basic Attributes

Class
MOLPATH.TRNLOC
Type
Laboratory
First Released
Version 1.0m
Last Updated
Version 2.73
Change Reason
Updated Component part to harmonize with ISCN guidelines and current LOINC nomenclature.
Order vs. Observation
Observation
Common Test Rank Get Info
18632

Language Variants Get Info

Tag Language Translation
es-AR Spanish (Argentina) translocación del gen T(2,5)(ALK,NPM1):arbitrario:punto en el tiempo:sangre entera/tejido:ordinal:genética molecular
es-ES Spanish (Spain) t(2;5)(p23;q35.1)(ALK,NPM1) Tránscritos de fusión:Arbitrario:Punto temporal:Sangre o tejido:Ord:Genética molecular
es-MX Spanish (Mexico) t (2; 5) (p23; q35.1) (ALK, NPM1) transcripción de fusión:Arbitrario:Punto temporal:Sangre o tejido:Ordinal:Genética molecular
fr-FR French (France) t(2;5)(p23;q35.1)(ALK,NPM1) transcrit de fusion:Arbitraire:Ponctuel:Sang/Tissu:Qualitatif:Biologie moléculaire
fr-CA French (Canada) t(2;5)(p23;q35.1)(ALK,NPM1) transcrit de fusion:Arbitraire:Temps ponctuel:Sang/Tissu:Ordinal:Molgen
it-IT Italian (Italy) t(2;5)(p23;q35.1)(ALK,NPM1), trascritto di fusione:Arb:Pt:Sangue/Tess:Ord:Molgen
Synonyms: Arbitrario Genetica molecolare Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci Traslocazione genetica
ko-KR Korean (Korea, Republic Of) t(2,5)(ALK,NPM1) 유전자 전위:임의적분:검사시점:전혈/조직:순위척도:분자유전
nl-NL Dutch (Netherlands) t(2;5)(p23;q35.1)(ALK,NPM1) fusietranscript:aanwezigheid:moment:bloed of weefsel:ordinaal:moleculair genetisch onderzoek
Synonyms: molgen
pt-BR Portuguese (Brazil) t(2,5)(ALK,NPM1) translocação do gene:Arb:Pt:Sg/Tecido:Ord:Genética molecular
Synonyms: Arbitrary; Point in time; Random; Bld/T; Tissue; Bld/T; Blood; WB; Whole blood; Ql; Ordinal; QL; Qualitative; Qual; Screen; PCR; Molecular genetics; Non-Hodgkin lymphoma; Anaplastic large cell lymphoma; t(2,5)(p23,q35); T prime; NPM; Nucleolar phosphoprotein b23; Numatrin; Anaplastic lymphoma kinase (Ki-1); II; MOLPATH.TRANSLOCATION; MOLPATH.TRANSLOCATION; Molecular pathology
ru-RU Russian (Russian Federation) t(2;5)(p23;q35.1)(ALK,NPM1) слияния транскрипт:Произв:ТчкВрм:Кр/Тк:Пор:МолГен
Synonyms: Кровь Кровь или Ткань Порядковый Произвольный Ткань и мазки Точка во времени;Момент химерная РНК, закодированная слитым геном
tr-TR Turkish (Turkey) t(2;5)(p23;q35.1)(ALK,NPM1) füzyon transkript:Sç:Zmlı:Kan/Dk:Srl:Molgen
zh-CN Chinese (China) t(2;5)(p23;q35.1)(ALK,NPM1) 融合转录物:任意型:时间点:全血/组织:序数型:分子遗传学类实验室方法
Synonyms: Ⅱ II NPM Numatrin T(2,5)(ALK,NPM1) 基因易位;T(2,5)(ALK,NPM1) 易位 任意;任意的;人工型 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 全血或组织;血液/组织;血液或组织 分子病理学.基因易位;分子病理学.易位;分子病理学试验.基因易位;分子病理学试验.易位;分子病理学试验类.易位;基因易位 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 核仁磷朊 b23 核仁磷蛋白 b23 核仁磷蛋白 b23（Nucleolar phosphoprotein b23，B23） 核仁磷蛋白 b23（Nucleophosmin，NPM，B23，Numatrin，NO38） 核仁磷酸化蛋白 核磷蛋白 核磷蛋白 1 核磷蛋白 1（Nucleophosmin，NPM，B23，N38，Numatrin） 核磷蛋白（Nuclear phosphoprotein，NPM） 融合转录物（转录本、转录产物、转录子、转录）;融合基因转录本;融合转录 血;血液 间变型淋巴瘤激酶 间变性淋巴瘤激酶（anaplastic lymphoma kinase，ALK）

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=21813-1