LP229750-7
t(2;5)(p23;q35.1)(ALK,NPM1) fusion transcript
Active
Description
The ALK gene encodes for the protein anaplastic lymphoma kinase (ALK) (also known as ALK tyrosine kinase receptor or CD246), and the NPM1 gene encodes for the protein nucleophosmin (also known as nucleolar phosphoprotein B23 or numatrin). PMID: 29455642 The 2;5 chromosomal translocation is associated with approximately 60% anaplastic large-cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2 and coding for the catalytic domain, is fused to the 5' portion of NPM from chromosome 5. The product of the NPM-ALK fusion gene is oncogenic. PMID: 17519389 Source: Regenstrief LOINC
Basic Part Properties
- Part Name
- t(2;5)(p23;q35.1)(ALK,NPM1) fusion transcript
- Part Display Name
- t(2;5)(p23;q35.1)(ALK,NPM1) fusion transcript
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2016-09-13
- Construct for LOINC Short Name
- t(2;5)(p23;q35.1)(ALK,NPM1) fusion transcript
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=LP229750-7
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| fr-CA | French (Canada) | t(2; |
LOINC Copyright
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