23997-0
Ganglioside GD1a IgG Ab [Titer] in Cerebrospinal Fluid by Immunoassay
Active
Part Descriptions
LP14393-0 Ganglioside GD1a
Gangliosides are a family of molecules that are present throughout the body but especially prevalent in cells of the nervous system. Specific gangliosides are named for the carbohydrate sequence they contain and have a unique distribution within the nervous system. The oligosaccharide groups on gangliosides act as cell surface markers that play a role in cellular recognition and cell-to-cell communication, and they also act as specific receptors for certain pituitary glycoprotein hormones and certain bacterial protein toxins such as cholera toxin.
Anti-ganglioside antibodies, primarily IgG, are present in the sera from approximately 60% of patients with Guillain-Barré syndrome (GBS), and antibodies against different gangliosides are associated with different forms of GBS.
1. Antibodies against GD1a/GD1b and GD1b/GT1b complexes have been found in patients with more severe GBS requiring mechanical ventilation;
2. Antibodies against GM1 or those against GalNAc-GD1a have been associated with acute motor axonal neuropathy;
3. Anti-GQ1b antibodies are specifically associated with a variant of GBS called Fisher syndrome, which is characterized by ophthalmoplegia and ataxia.
Detection of specific markers early in the course of GBS may help guide the plan of care. PMID: 21214559
Source: Regenstrief LOINC,
PMID: 2121455
LP222219-0 Ganglioside
A ganglioside molecule consists of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acid residues linked to the sugar chain. Molecules with one sialic acid residue are called monosialogangliosides (GM), those with two are called disialogangliosides (GD), and those with three are trisialogangliosides (GT). Gangliosides without any sialic acid residues are called asialogangliosides, while those that do not have a ceramide N-acyl group are called lysogangliosides. The number that typically is included at the end of the name indicates the order in which the molecule was discovered. For example, GM2 is a ganglioside with one sialic acid residue that was the second GM to be identified.
Source: Regenstrief LOINC
LOINC Names Get Info
- Fully-Specified Name
- Ganglioside GD1a Ab.IgG:
Titr: Pt: CSF: SemiQn: IA - Long Common Name
- Ganglioside GD1a IgG Ab [Titer] in Cerebrospinal Fluid by Immunoassay
- Short Name
- GD1a Gangl IgG Titr CSF IA
- Display Name
- Ganglioside GD1a IgG IA (CSF) [Titer]
- Consumer Name Alpha Get Info
- Ganglioside GD1a IgG antibody, Spinal fluid
Part Model Get Info
- Component
- Ganglioside GD1a Ab.IgG
LP38220-7
- Analyte
- Ganglioside GD1a Ab.IgG
LP38220-7
- Challenge
- NULL
- Adjustment
- NULL
- Count
- NULL
- Property
- Titr
LP6881-9
- Time
- Pt
LP6960-1
- Time Core
- Pt
LP6960-1
- Time Modifier
- NULL
- System
- CSF
LP7156-5
- System Core
- CSF
LP7156-5
- Super System
- NULL
- Scale
- SemiQn
LP436123-6
- Method
- IA
LP217197-5
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 1.0o
- Last Updated
- Version 2.83 (MIN)
- Change Reason
- The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Observation
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Gangliosid GD1a IgG: |
| el-GR | Greek (Greece) | Γαγγλιοσίδη GD1a Αντισώματα IgG: Synonyms: IA Pt SERO Titr Ανοσοσφαιρίνη G Αντίσωμα Αντισώματα IgG Γαγγλιοσίδη Γαγγλιοσίδη GD1a ΕΝΥ Ημιποσοτική |
| es-AR | Spanish (Argentina) | [anticuerpo anti - ] gangliósido GD1A [Ac].IgG [Inmunoglobulina G]: |
| es-ES | Spanish (Spain) | Gangliosido GD1a IgG: Synonyms: Semicuantitativo |
| es-MX | Spanish (Mexico) | Gangliósido GD1a Ab.IgG: |
| fr-FR | French (France) | Ganglioside GD1a Ac IgG: |
| fr-CA | French (Canada) | Ganglioside GD1a, IgG: |
| it-IT | Italian (Italy) | Ganglioside GD1a Ab.IgG: Synonyms: anticorpi IgG anticorpo Immunoassay Liquido cerebrospinale Punto nel tempo (episodio) Sierologia (anticorpi e la maggior parte degli ant Titolo |
| ko-KR | Korean (Korea, Republic Of) | 강글리오시드 GD1a 항체.면역글로불린 G: |
| nl-NL | Dutch (Netherlands) | ganglioside GD1a As.IgG: Synonyms: antistof; |
| pl-PL | Polish (Poland) | Gangliozyd GD1a Ab.IgG: Synonyms: IgG Przeciwciała do gangliozydu GD1a przeciwciała IgG Przeciwciała IgG do gangliozydu GD1a |
| pt-BR | Portuguese (Brazil) | Gangliosideo GD1a Ac.IgG: Synonyms: Immune globulin G; |
| zh-CN | Chinese (China) | 神经节苷脂 GD1a 抗体.IgG: Synonyms: Ab.IgG; |
Example Units
| Unit | Source |
|---|---|
| {titer} | Example UCUM Units |
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LOINC Copyright
Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://