Version 2.77

Part Descriptions

LP15794-8   Phenylpyruvate
Phenylpyruvic acid is a pyruvic acid derivative. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

LP15794-8   Phenylpyruvate
Phenylpyruvic acid is a keto-acid that is an intermediate or catabolic byproduct of phenylalanine metabolism. It has a slight honey-like odor. Levels of phenylpyruvate are normally very low in blood or urine. High levels of phenylpyruvic acid can be found in the urine of individuals with phenylketonuria (PKU). PKU is due to lack of the enzyme phenylalanine hydroxylase (PAH), so that phenylalanine is converted not to tyrosine but to phenylpyruvic acid. In particular, excessive phenylalanine can be metabolized into phenylketones through, a transaminase pathway route involving glutamate. Metabolites of this transamination reaction include phenylacetate, phenylpyruvate and phenethylamine. In persons with PKU, dietary phenylalanine either accumulates in the body or some of it is converted to phenylpyruvic acid. Individuals with PKU tend to excrete large quantities of phenylpyruvate, phenylacetate and phenyllactate, along with phenylalanine, in their urine. If untreated, mental retardation effects and microcephaly are evident by the first year along with other symptoms which include: unusual irritability, epileptic seizures and skin lesions. Hyperactivity, EEG abnormalities and seizures, and severe learning disabilities are major clinical problems later in life. A "musty or mousy" odor of skin, hair, sweat and urine (due to phenylacetate accumulation); and a tendency to hypopigmentation and eczema are also observed. The neural-development effects of PKU are primarily due to the disruption of neurotransmitter synthesis. In particular, phenylalanine is a large, neutral amino acid which moves across the blood-brain barrier (BBB) via the large neutral amino acid transporter (LNAAT). Excessive phenylalanine in the blood saturates the transporter. Thus, excessive levels of phenylalanine significantly decrease the levels of other LNAAs in the brain. But since these amino acids are required for protein and neurotransmitter synthesis, phenylalanine accumulation disrupts brain development, leading to mental retardation. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Human Metabolome Database

LP32035-5   Creatinine
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. It is transferred to the kidneys by blood plasma, whereupon it is eliminated by glomular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate and measuring its serum level is a simple test. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Creatinine

Fully-Specified Name

Component
Phenylpyruvate/Creatinine
Property
SRto
Time
Pt
System
Urine
Scale
Qn
Method

Additional Names

Short Name
Phenylpyruvate/Creat Ur-sRto
Display Name
Phenylpyruvate/Creatinine (U) [Molar ratio]
Consumer Name Alpha Get Info
Phenylpyruvate/Creatinine, Urine

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.00
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
10337

Member of these Panels

LOINC Long Common Name
48797-5 Organic acids panel - Urine

Member of these Groups Get Info

LOINC Group Group Name
LG35328-0 Phenylpyruvate/Creatinine|SRto|Urine

Language Variants Get Info

Tag Language Translation
es-AR Spanish (Argentina) fenilpiruvato/creatinina:relación de concentración de la sustancia:punto en el tiempo:orina:cuantitativo:
es-ES Spanish (Spain) Fenilpiruvato/Creatinina:Relacion de Sustancia:Punto temporal:Orina:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Fenilpiruvato / Creatinina:Proporción de sustancia:Punto temporal:Orina:Cuantitativo:
fr-CA French (Canada) Phénylpyruvate/Créatinine:Ratio de substance:Temps ponctuel:Urine:Quantitatif:
fr-FR French (France) 3-phénylpyruvate/créatinine:Moles ratio:Ponctuel:Urine:Numérique:
fr-BE French (Belgium) Phénylpyruvate/Créatinine:Ratio de substance:Temps ponctuel:Urine:Quantitatif:
it-IT Italian (Italy) Fenilpiruvato/Creatinina:Srto:Pt:Urine:Qn:
Synonyms: Chimica Punto nel tempo (episodio) Rapporto di sostanza
ko-KR Korean (Korea, Republic Of) 페닐피루브산염/크레아티닌:물질구성비:검사시점:뇨:정량:
nl-NL Dutch (Netherlands) fenylpyruvaat/creatinine:molaire verhouding:moment:urine:kwantitatief:
Synonyms: kreatinine
pl-PL Polish (Poland) Kwas fenylopirogronowy/kreatynina:współczynnik molowy:punkt w czasie:mocz:ilościowy:
pt-BR Portuguese (Brazil) Fenilpiruvato/Creatinina:SCrto:Pt:Urina:Qn:
Synonyms: Phenylpyruvic acid; Creat; CR; sRto; Substance concentration ratio; Point in time; Random; Ur; UR; Urn; UA; Quantitative; QNT; Quant; Quan; Chemistry; UCr
ru-RU Russian (Russian Federation) Фенилпируват/Креатинин:МольОтн:ТчкВрм:Моча:Колич:
Synonyms: Количественный Мольная доля;Молярная доля;Отношение концентраций Точка во времени;Момент
tr-TR Turkish (Turkey) Fenilpiruvat/Kreatinin:SOrn:Zmlı:İdrar:Kant:
Synonyms: SubsOranı
zh-CN Chinese (China) 苯丙酮酸/肌酐:物质的量比率:时间点:尿液:定量型:
Synonyms: CR;Creat;肌氨酸酐;肌酸内酰胺;肌酸酐 UCr 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 尿;小便;下泉 尿液肌酐 尿液肌酸酐 尿肌酸酐 时刻;随机;随意;瞬间 物质的量比值;物质的量比;摩尔比;摩尔比率;摩尔比值 肌酸内酰胺

Example Units

Unit Source
mmol/mol cr REGENSTRIEF
mmol/mol{creat} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=25126-4