2532-0
Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma
Discouraged
Status Information
- Status
- DISCOURAGED
- Comment
- Because there is a 3-fold difference in normal range between L>P and P>L methods, the use of the methodless term is not recommended.
Map-To | Long Common Name | Mapping Guidance |
---|---|---|
14804-9 | Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction | |
14805-6 | Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Pyruvate to lactate reaction |
Part Descriptions
LP15033-1 Lactate dehydrogenase
Lactate dehydrogenase (LDH) is an enzyme (EC 1.1.1.27) present in a wide variety of organisms, including plants and animals. It catalyses the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+. As it can also catalyze the oxidation of hydroxybutyrate, it is occasionally called hydroxybutyrate dehydrogenase (HBD).
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Source: Wikipedia, D-lactate (Wikipedia)
LP15033-1 Lactate dehydrogenase
Lactate dehydrogenase (LDH, or also called LD) is an oxidoreductase (LD: EC 1.1.1.27) and is the most important clinically of several dehydrogenases occurring in human serum. LDH catalyses the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD. When disease, injury, or toxic material damages tissues, cells release LDH into the bloodstream. Since LDH is a fairly stable enzyme, it has been widely used to evaluate the presence of damage and toxicity of tissue and cells. LDH is cytoplasmic in its cellular location and in any one tissue is composed of one or two of five possible isoenzymes. While many of its clinical applications involve quantification of one or more specific serum isoenzymes, an estimate of total LDH is usually required. Lactate dehydrogenase catalyzes the reversible reaction: L-lactate + NAD <--> pyruvate + NADH. Testing methods either measure the increase in NADH produced in the lactate-to-pyruvate reaction or the decrease in NADH produced in the pyruvate-to-lactate reaction. PMID: 3882046. Reference ranges are highly method dependent. The pyruvate-to-lactate reaction is preferred theoretically because the equilibrium constant is large and the rate for any amount of enzyme is 2-3 times faster, thus smaller sample and shorter observation periods are needed. Disadvantages of the pyruvate-to-lactate reaction are loss of linearity as compared with the lactate-to-pyruvate reaction, and greater substrate inhibition of the enzyme. [Tietz Fourth Edition]
Source: Regenstrief LOINC
Reference Information
Type | Source | Reference |
---|---|---|
Webcontent | Lab Tests Online®Copyright Copyright © 2021 Lab Tests Online. All rights reserved. | Lactate Dehydrogenase (LD) |
Fully-Specified Name
- Component
- Lactate dehydrogenase
- Property
- CCnc
- Time
- Pt
- System
- Ser/Plas
- Scale
- Qn
- Method
Additional Names
- Short Name
- LDH SerPl-cCnc
- Display Name
- LDH [Catalytic activity/Vol]
- Consumer Name Alpha Get Info
- Lactate Dehydrogenase (LDH), Blood
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 1.0
- Last Updated
- Version 2.73
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 238
Member of these Panels
LOINC | Long Common Name |
---|---|
42929-0 | Lactate dehydrogenase panel - Serum or Plasma |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
de-DE | German (Germany) | Lactatdehydrogenase: Synonyms: LDH |
de-AT | German (Austria) | Synonyms: LDH |
el-GR | Greek (Greece) | Γαλακτική αφυδρογονάση: Synonyms: LDH |
es-AR | Spanish (Argentina) | lactato deshidrogenasa: |
es-MX | Spanish (Mexico) | Lactato deshidrogenasa: |
es-ES | Spanish (Spain) | Lactato deshidrogenasa: Synonyms: Cuantitativo |
et-EE | Estonian (Estonia) | Laktaadi dehüdrogenaas: Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma |
fr-FR | French (France) | Lactate déhydrogénase: |
fr-CA | French (Canada) | Lactate déshydrogénase: |
fr-BE | French (Belgium) | Lactate déshydrogénase: Synonyms: LDH |
it-IT | Italian (Italy) | Lattato deidrogenasi: Synonyms: Chimica Concentrazione Catalitica Plasma Punto nel tempo (episodio) Siero Siero o Plasma |
ko-KR | Korean (Korea, Republic Of) | 젖산 탈수소효소: |
nl-NL | Dutch (Netherlands) | lactaatdehydrogenase: |
pl-PL | Polish (Poland) | Dehydrogenaza mleczanowa: |
pt-BR | Portuguese (Brazil) | Desidrogenase Láctica: Synonyms: ; |
ru-RU | Russian (Russian Federation) | Лактатдегидрогеназа: Synonyms: Каталитическая концентрация Количественный Плазма Сыворотка Сыворотка или Плазма Точка во времени; |
tr-TR | Turkish (Turkey) | Laktat dehidrojenaz: |
uk-UA | Ukrainian (Ukraine) | Лактатдегідрогеназа: Synonyms: 2-Hydroxypropanoic acid; |
zh-CN | Chinese (China) | 乳酸脱氢酶: Synonyms: 2-羟基-丙酸; |
Example Units
Unit | Source |
---|---|
U/L | Example UCUM Units |
U/L | eCHN |
units/L | REGENSTRIEF |
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