26977-9
Coproporphyrin 1 [Presence] in Stool
Active
Part Description
LP18633-5 Coproporphyrin 1
Coproporhyrin I is a porphyrin metabolite arising from heme synthesis. Porphyrins are pigments found in both animal and plant life. Coproporphyrin I is a tetrapyrrole dead-end product from the spontaneous oxidation of the methylene bridges of coproporphynogen, arising from heme synthesis and secreted in feces and urine. Increased levels of coproporphyrins can indicate congenital erythropoietic porphyria or sideroblastic anaemia. Porphyria is a pathological state characterised by abnormalities of porphyrin metabolism and results in the excretion of large quantities of porphyrins in the urine and in extreme sensitivity to light. A large number of factors are capable of increasing porphyrin excretion, owing to different and multiple causes and etiologies: 1) the main site of the chronic hepatic porphyria disease process concentrates on the liver, 2) a functional and morphologic liver injury is almost regularly associated with this chronic porphyria, 3) the toxic form due to occupational and environmental exposure takes mainly a subclinical course. Hepatic factors includes disturbance in coproporphyrinogen metabolism, which results from inhibition of coproporphyrinogen oxidase as well as from the rapid loss from, and diminished utilization of coproporphyrinogen in the hepatocytes, which may also explain why coproporphyrin, its autoxidation product, predominates physiologically in the urine; decreased biliary excretion of coproporphyrin leading to a compensatory urinary excretion, so that the coproporphyrin ring isomer ratio (1:III) becomes a sensitive index for impaired liver function and intrahepatic cholestasis; and disturbed activity of hepatic uroporphyrinogen decarboxylase. In itself, secondary coproporphyrinuria is not associated with porphyria symptoms of a hepatologic-gastroenterologic, neurologic, or dermatologic order, even though coproporphyrinuria can occur with such symptoms. PMID: 3327428
Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.)
Source: Human Metabolome Database,
Corproporphyrin I
LOINC Names Get Info
- Fully-Specified Name
- Coproporphyrin 1:
PrThr: Pt: Stool: Ord: - Long Common Name
- Coproporphyrin 1 [Presence] in Stool
- Short Name
- Copro1 Stl Ql
- Display Name
- Coproporphyrin 1 Ql (Stl)
- Consumer Name Alpha Get Info
- Coproporphyrin 1, Stool
Part Model Get Info
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.00
- Last Updated
- Version 2.56 (MIN)
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Observation
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Koproporfyrin 1: |
| el-GR | Greek (Greece) | Κοπροπορφυρίνη 1: Synonyms: CHEM Ord PrThr Pt Κόπρανα Κοπροπορφυρίνη Κοπροπορφυρίνη 1 |
| es-AR | Spanish (Argentina) | coproporfirina 1: |
| es-ES | Spanish (Spain) | Coproporfirina 1: |
| es-MX | Spanish (Mexico) | Coproporfirina 1: |
| et-EE | Estonian (Estonia) | Koproporfüriin 1: Synonyms: Järgarvuline Juhuslik Roe |
| fr-CA | French (Canada) | Coproporphyrine 1: |
| fr-FR | French (France) | Coproporphyrine 1: |
| fr-BE | French (Belgium) | Coproporphyrine 1: |
| it-IT | Italian (Italy) | Coproporfirina 1: Synonyms: Chimica Presenza o Soglia Punto nel tempo (episodio) |
| ko-KR | Korean (Korea, Republic Of) | 코프로포르피린 1: |
| nl-NL | Dutch (Netherlands) | coproporfyrine 1: Synonyms: ontlasting; |
| pt-BR | Portuguese (Brazil) | Coproporfirina 1: Synonyms: ; |
| ru-RU | Russian (Russian Federation) | Копропорфирин 1: Synonyms: Порядковый Точка во времени; |
| tr-TR | Turkish (Turkey) | Koproporfirin 1: Synonyms: Gaita; |
| zh-CN | Chinese (China) | 粪卟啉 I: Synonyms: Ⅰ Copro; |
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LOINC Copyright
Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://