LOINC
Version 2.67

28008-1Cytomegalovirus DNA [Presence] in Blood by Probe with signal amplificationActive

Part Description

LP14255-1   Cytomegalovirus
Cytomegalovirus is a member of the family Herpesviridae and also known as Human Herpesvirus-5 (HHV-5). It contains a linear double-stranded DNA encased in an icosahedral capsid that is surrounded by a viral envelope. It replicates slowly and may take weeks for the infection to become visible microscopically. Its life cycle includes a lytic and a latent phase. During the lytic phase the cytoskeleton of the infected cell is disrupted and becomes very large. The enlarged cell eludes detection by natural killer (NK) cells by encoding UL16. UL16 is a protein that binds to the ligand NDG2D which is a surface receptor on NK cells and, when blocked, prevents the CMV infected cell from apoptotic signaling to NK cells to destroy it.[https://pedclerk.bsd.uchicago.edu/page/cytomegalovirus-cmv] In the US one in three children are infected by CMV by the age of five and over half of adults are infected by age 40. Infection with CMV is mostly asymptomatic. Symptoms when present include fever, sore throat, fatigue, swollen glands. CMV can occasionally lead to mononucleosis or hepatitis. Immunocompromised patients experience much more acute symptoms that can affect the eyes, lungs, liver, esophagus, stomach, and intestines. For babies born with CMV, involvement with the brain, spleen, lung, liver can occur. In addition, there may be growth problems and hearing loss which is the most common symptom in congenital CMV infection. CMV is transmitted in urine, saliva, blood, tears, semen and breast milk by direct contact. Normally no treatment is necessary, but for severe cases medication is available.[https://www.cdc.gov/cmv/overview.html] Source: Regenstrief LOINC

Fully-Specified Name

Component
Cytomegalovirus DNA
Property
PrThr
Time
Pt
System
Bld
Scale
Ord
Method
Probe.amp.sig

Additional Names

Short Name
CMV DNA Bld Ql Probe+sig amp
Display Name
CMV DNA Probe+sig amp Ql (Bld)

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.00
Last Updated
Version 2.65
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; Updated Answer list type from NORMATIVE to EXAMPLE because the Answers in the list (Positive, Negative) are only examples of possible answers and not an exclusive list
Order vs. Observation
Both
Common US Lab Results Rank
915
Common SI Lab Results Rank
915

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Language Variants Get Info

zh-CNChinese (CHINA)
巨细胞病毒 DNA:存在情况或阈值:时间点:全血:序数型:探针法.基因扩增.信号
nl-NLDutch (NETHERLANDS)
Cytomegalovirus DNA:aanwezigheid:moment:bloed:ordinaal:probe.amp.sig
fr-BEFrench (BELGIUM)
Cytomégalovirus ADN:PrThr:Temps ponctuel:Sang:Ordinal:Sonde avec amplification du signal
fr-CAFrench (CANADA)
Cytomégalovirus , ADN:Présence-Seuil:Temps ponctuel:Sang:Ordinal:Sonde avec amplification du signal
fr-FRFrench (FRANCE)
Cytomégalovirus ADN:Présence/Seuil:Ponctuel:Sang:Qualitatif:PCR amplification du signal
de-DEGerman (GERMANY)
Cytomegalievirus DNA:AKnz:Pkt:Blut:Ord:Probe.amp.sig
it-ITItalian (ITALY)
Citomegalovirus , DNA:PrThr:Pt:Sangue:Ord:Sonda.amp.sig
ko-KRKorean (KOREA, REPUBLIC OF)
거대세포바이러스 디옥시리보핵산:임의농도:검사시점:전혈:순위척도:DNA 탐색자.증폭.sig
pt-BRPortuguese (BRAZIL)
Citomegalovírus DNA:ACnc:Pt:SgTotal:Ord:Sonda com amplificação de sinal
ru-RURussian (RUSSIAN FEDERATION)
Цитомегаловирус ДНК:PrThr:ТчкВрм:Кр:Пор:Проба.усил.сигн
es-ARSpanish (ARGENTINA)
ADN de citomegalovirus:concentración arbitraria:punto en el tiempo:sangre:ordinal:sonda con amplificación de la señal
es-ESSpanish (SPAIN)
Citomegalovirus ADN:PrThr:Punto temporal:Sangre:Ord:Sonda con amplificación de señal
tr-TRTurkish (TURKEY)
Cytomegalovirus DNA:MevcEşik:Zmlı:Kan:Srl:Prob.amf.siny

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=28008-1