29526-1

Azelate/Creatinine [Molar ratio] in Urine

Active

Part Descriptions

LP18430-6 Azelate
Azelaic acid (AZA) is a naturally occurring saturated nine-carbon dicarboxylic acid (COOH (CH2)7-COOH). It possesses a variety of biological actions both in vitro and in vivo. Interest in the biological activity of AZA arose originally out of studies of skin surface lipids and the pathogenesis of hypochromia in pityriasis versicolor infection. Later, it was shown that Pityrosporum can oxidize unsaturated fatty acids to C8-C12 dicarboxylic acids that are cornpetitive inhibitors of tyrosinase in vitro. Azelaic acid was chosen for further investigation and development of a new topical drug for treating hyperpigmentary disorders for the following reasons: it possesses a middle-range of antityrosinase activity, is inexpensive, and more soluble to be incorporated into a base cream than other dicarboxylic acids. Azelaic acid is another option for the topical treatment of mild to moderate inflammatory acne vulgaris. It offers effectiveness similar to that of other agents without the systemic side effects of oral antibiotics or the allergic sensitization of topical benzoyl peroxide and with less irritation than tretinoin. Azelaic acid is less expensive than certain other prescription acne preparations, but it is much more expensive than nonprescription benzoyl peroxide preparations. Whether it is safe and effective when used in combination with other agents is not known. PMID: 7737781 PMID: 8961845 Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database , Azelaic acid

LP32035-5 Creatinine
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. It is transferred to the kidneys by blood plasma, whereupon it is eliminated by glomular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate and measuring its serum level is a simple test. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database , Creatinine

Fully-Specified Name

Component: Azelate/Creatinine
Property: SRto
Time: Pt
System: Urine
Scale: Qn
Method

Additional Names

Long Common Name: Azelate/Creatinine [Molar ratio] in Urine
Short Name: Azelate/Creat Ur-sRto
Display Name: Azelate/Creatinine (U) [Molar ratio]
Consumer Name Alpha Get Info: Azelate/Creatinine, Urine

Basic Attributes

Class: DRUG/TOX
Type: Laboratory
First Released: Version 2.03
Last Updated: Version 2.73 (MIN)
Order vs. Observation: Both
Common Test Rank Get Info: 12539

Member of these Panels

LOINC	Long Common Name
48797-5	Organic acids panel - Urine

Language Variants Get Info

Tag	Language	Translation
el-GR	Greek (Greece)	Αζελαϊκό οξύ/Κρεατινίνη:SRto:Pt:Ούρα:Qn: Synonyms: SRto
es-AR	Spanish (Argentina)	azelato/creatinina:relación de concentración de la sustancia:punto en el tiempo:orina:cuantitativo:
es-ES	Spanish (Spain)	Azelato/Creatinina:Relacion de Sustancia:Punto temporal:Orina:Qn: Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Azelato / creatinina:Proporción de sustancia:Punto temporal:Orina:Cuantitativo:
fr-CA	French (Canada)	Azélate/Créatinine:Ratio de substance:Temps ponctuel:Urine:Quantitatif:
fr-FR	French (France)	Azélate/créatinine:Moles ratio:Ponctuel:Urine:Numérique:
fr-BE	French (Belgium)	Azélate/Créatinine:Ratio de substance:Temps ponctuel:Urine:Quantitatif:
it-IT	Italian (Italy)	Azelato/Creatinina:Srto:Pt:Urine:Qn: Synonyms: Livelli farmacologici e tossicologia Punto nel tempo (episodio) Rapporto di sostanza
ko-KR	Korean (Korea, Republic Of)	아젤레이트/크레아티닌:물질구성비:검사시점:뇨:정량:
nl-NL	Dutch (Netherlands)	azelaat/creatinine:molaire verhouding:moment:urine:kwantitatief: Synonyms: kreatinine
pt-BR	Portuguese (Brazil)	Azelato/Creatinina:SCrto:Pt:Urina:Qn: Synonyms: Azelex; Nonanedioate; Nonanedioic acid; Azelaic acid; Creat; CR; sRto; Substance concentration ratio; Point in time; Random; Ur; UR; Urn; UA; Quantitative; QNT; Quant; Quan; Drugs; DRUG/TOXICOLOGY; DRUG/TOXICOLOGY; UCr
ru-RU	Russian (Russian Federation)	Азелат/Креатинин:МольОтн:ТчкВрм:Моча:Колич: Synonyms: Количественный Мольная доля;Молярная доля;Отношение концентраций Точка во времени;Момент
tr-TR	Turkish (Turkey)	Azelat/Kreatinin:SOrn:Zmlı:İdrar:Kant: Synonyms: SubsOranı
zh-CN	Chinese (China)	壬二酸/肌酐:物质的量比率:时间点:尿液:定量型: Synonyms: CR;Creat;肌氨酸酐;肌酸内酰胺;肌酸酐 UCr 可用数量表示的;定量性;数值型;数量型;连续数值型标尺壬二酸盐;壬二酸酯尿;小便;下泉尿液肌酐尿液肌酸酐尿肌酸酐时刻;随机;随意;瞬间毒品毒品类物质的量比值;物质的量比;摩尔比;摩尔比率;摩尔比值肌酸内酰胺药品类药物药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类药物类

Example Units

Unit	Source
mmol/mol cr	REGENSTRIEF
mmol/mol{creat}	Example UCUM Units

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