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Part Descriptions

LP207365-0   Ab.Neut
Neutralizing antibodies are antibodies that interfere with the interaction between the virus and its host cell receptor, therefore preventing infectivity. Neutralizing antibodies can be detected using a traditional VNT or other methods such as pseudovirus VNT and surrogate VNT. VNT and pseudovirus VNT use live virus (the actual virus or a recombinant virus that incorporates the viral antigen of interest, respectively) and cell culture to assess the virus-host interaction and whether neutralizing antibodies are present that block that interaction. Surrogate VNT (sVNT) does not use live virus but rather uses purified viral antigen and host cell receptor protein to mimic the same interaction. The sVNT method is currently (2021) represented in LOINC as IA, because it is an immunoassay-based method. Source: Regenstrief LOINC

LP28423-9   West Nile virus
The West Nile Virus (WNV) is an arbovirus that was first identified in the West Nile District of Uganda in 1937. In the fall of 1999, the National Veterinary Services Laboratory (NVLS) isolated WNV in a dead crow in New York City.(http://www.who.int/mediacentre/factsheets/fs354/en/) Over the following ten years, WNV spread throughout the United States, Canada, Mexico and the Carribbean. WNV is usually transmitted through the bite of the Culex mosquito, but can also be spread in blood transfusions, organ transplants, breast milk, intrauterine exposure and laboratory-acquired infections. Birds are the preferred host of WNV, and the American robin is an important amplifier host since it develops enough virus in its serum to infect feeding mosquitoes. Though most infections with WNV are subclinical for humans, between 2005 and 2009 there were 12,975 people infected with WNV, of which 35% had severe cases of neuroinvasive disease and 496 people died. For individuals who are 70 years of age or older, infection with WNV has a 15-29% fatality rate. For infants and immunocompromised patients infected with WNV, the fatality rate is even higher. Diagnosis of WNV is based on clinical symptoms and antibody titers. The IgM antibody-capture enzyme-linked immunosorbent assay (MAC-ELISA) is the key method used to diagnosis WNV in clinical settings. Antibody titers to WNV NS5 are detectable long-term in vivo and can be used to distinguish past infection with WNV from current infection. RNA is usually undetectable in serum after 13.2 days, but on rare occasions, has been found in serum beyond 40 days. Treatment of infection with WNV is mostly supportive. There are no FDA-approved drugs or vaccines available. PMID: 12089283 PMID: 23034323 Source: Regenstrief LOINC

LP6416-4   Neut
In LOINC, the Method "Neut" represents the virus neutralization test (VNT), also called conventional VNT, which is a specific laboratory method that is used primarily for identifying whether neutralizing antibodies for the virus of interest are present in the patient sample. The VNT involves incubating patient serum with the virus of interest, and then inoculating onto cell culture. If neutralizing antibodies are present and the virus is neutralized, the cells will not be infected. If neutralizing antibodies are not present, the virus will infect the cells in the cell culture. PMID: 32170698 This method can also be used to identify specific virus serotypes or strains, by performing separate tests in which serum is incubated with each of the specific virus serotypes or strains of interest. PMID: 169804 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
West Nile virus Ab.Neut:Titr:Pt:CSF:SemiQn:Neut
Long Common Name
West Nile virus neutralizing antibody [Titer] in Cerebrospinal Fluid by Neutralization test
Short Name
WNV NAb Titr CSF Nt
Display Name
West Nile virus neut ab Neut test (CSF) [Titer]
Consumer Name Alpha Get Info
West Nile virus neutralizing antibody, Spinal fluid

Part Model Get Info

  • Component
    West Nile virus Ab.Neut
    LP430485-5
    • Analyte
      West Nile virus Ab.Neut
      LP430485-5
      • Component Numerator
        West Nile virus Ab.Neut
        LP430485-5
        • Component Numerator Core
          West Nile virus
          LP28423-9
        • Component Numerator Core Suffix
          Ab.Neut
          LP207365-0
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Titr
    LP6881-9
  • Time
    Pt
    LP6960-1
  • System
    CSF
    LP7156-5
    • System Core
      CSF
      LP7156-5
    • Super System
      NULL
       
  • Scale
    SemiQn
    LP436123-6
  • Method
    Neut
    LP6416-4

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.03
Last Updated
Version 2.83 (MIN)
Change Reason
Release 2.72: COMPONENT: Updated "Ab" to "Ab.Neut" since this test is detecting neutralizing antibodies.;
Order vs. Observation
Both

Member of these Groups Get Info

LOINC GroupGroup Name
LG32768-0West Nile virus

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Virus západonilské horečky Ab.neutralizační:Arbitrární koncentrace (titr):Časový bod:Mozkomíšní mok:Semikvantitativní:Neutralizační test
de-DEGerman (Germany)West-Nil-Virus Ak.neutralisierend:Titer:Zeitpunkt:Liquor:Semiquantitativ:Neutralisationstest
Synonyms: Zerebrospinalflüssigkeit
el-GRGreek (Greece)Ιός Δυτικού Νείλου Ab.Neut:Titr:Pt:ΕΝΥ:Ημιποσοτική:Ουδετερόφιλα
Synonyms: Ab.Neut MICRO Pt Titr Αντίσωμα ΕΝΥ Ημιποσοτική Ιός Ιός Δυτικού Νείλου Ουδετερόφιλα
es-ARSpanish (Argentina)anticuerpo contra virus del Nilo occidental:factor de dilución (titulación):punto en el tiempo:líquido cefalorraquídeo:cuantitativo:neutralización
es-ESSpanish (Spain)Virus Nilo Occidental Anticuerpos antineutrófilos:Titulo / Factor de dilución:Punto temporal:Líquido Cefalorraquideo:Semicuantitativo:Prueba de neutralización
Synonyms: Semicuantitativo
es-MXSpanish (Mexico)Ab virus del Nilo Occidental:Título:Punto temporal:Fluído espinal cerebral:Cuantitativo:Prueba de neutralización
fr-FRFrench (France)West Nile virus Ac neutralisant:Titre:Ponctuel:Liquide céphalorachidien:Semi-Quantitatif:Neutralisation
fr-CAFrench (Canada)Virus du Nil occidental Ac.neut:Titre:Temps ponctuel:LCR:SemiQn:Test de neutralisation
it-ITItalian (Italy)Nilo occidentale, virus Ab.Neut:Titr:Pt:LCS:SemiQn:Neut
Synonyms: anticorpo Liquido cerebrospinale Microbiologia Punto nel tempo (episodio) Test di neutralizzazione Titolo Virus del Nilo occidentale
ko-KRKorean (Korea, Republic Of)웨스트 나일 바이러스 항체:역가:검사시점:뇌척수액:정량:중화
nl-NLDutch (Netherlands)West-Nijlvirus As.neutraliserend:titer:moment:liquor cerebrospinalis:semikwantitatief:neutralisatietest
Synonyms: antistof; antilichaam
pl-PLPolish (Poland)Wirus gorączki zachodniego Nilu Ab.Neutralizujące:miano:punkt w czasie:płyn mózgowo-rdzeniowy:półilościowy:test neutralizacji
Synonyms: Przeciwciała do wirusa gorączki zachodniego Nilu Przeciwciała neutralizujące do wirusa gorączki zachodniego Nilu
pt-BRPortuguese (Brazil)Vírus do Nilo Ocidental Ac:Título:Pt:LCR:Qn:Teste de neutralização
Synonyms: ; WNV; Dilution factor; Titer; Titre; Ttr; Titered; Point in time; Random; Cerebral spinal fluid; Spinal Fluid; Cerebrospinal Fl; Spinal Flu; Spinal Fld; Quantitative; QNT; Quant; Quan; Nt; NT; Neutralization test; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; Microbiology
zh-CNChinese (China)西尼罗河病毒 抗体.中和:滴定度:时间点:脑脊液:半定量型:中和试验
Synonyms: Ab;自身抗体 CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 WNV Ab WNV 抗体 WNV;西尼罗河热;西尼罗河热病毒 中和试验;中和抗体;中和 传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 效价;滴定浓度;滴定率;滴定量;滴度;稀释倍数;稀释因子;稀释系数 时刻;随机;随意;瞬间 脊液 脊髓液 脑脊液（Cerebral spinal fluid，CSF） 脑脊髓液 西尼罗河热病毒 Ab 西尼罗河热病毒抗体 西尼罗河病毒 Ab

Example Units

UnitSource
{titer}Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=29570-9