29617-8

CD23 Ag [Presence] in Tissue by Immune stain

Active

Part Descriptions

LP20016-9 CD23
Found on mature B-cells.
Associated with B-cell CLL and Nodal small lymphocytic lymphoma
Usually absent in mantle cell lymphoma Source: Regenstrief Institute

LP20016-9 CD23
CD23, also known as Fc epsilon RII, or FcεRII, is the "low affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites and is important in regulation of IgE levels. Unlike many of the antibody receptors, CD23 is a C-type lectin. It is found on mature B cells, activated macrophages, eosinophils, follicular dendritic cells and platelets.

There are two forms of CD23: CD23a and CD23b. CD23a is unconditionally present on B cells, while CD23b requires IL-4 to be expressed on T-cells, monocytes, Langerhans cells, eosinophils and macrophages.

The allergen responsible in dust mite allergy, Der-p-1, is known to cleave CD23 from a cells surface. As CD23 is soluble it can move freely and interact with cells in plasma. Recent studies have shown that increased levels of soluble CD23 cause the recruitment of non-sensitised B-cells in the presentation of antigen peptides to allergen specific B-cells, therefore increasing the production of allergen specific IgE. IgE in turn is known to upregulate the cellular expression of CD23 and Fc epsilon RI (high affinity IgE receptor). Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, CD23

LOINC Names Get Info

Fully-Specified Name: CD23 Ag:PrThr:Pt:Tiss:Ord:Immune stain
Long Common Name: CD23 Ag [Presence] in Tissue by Immune stain
Short Name: CD23 Ag Tiss Ql ImStn
Display Name: CD23 Ag Immune stain Ql (Tiss)
Consumer Name Alpha Get Info: CD23 antigen, Tissue

Part Model Get Info

Component
CD23 Ag
LP37561-5
- Analyte
  CD23 Ag
  LP37561-5
  - Component Numerator
    CD23 Ag
    LP37561-5
    - Component Numerator Core
      CD23
      LP20016-9
    - Component Numerator Core Suffix
      Ag
      LP20666-1
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
PrThr
LP217195-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Tiss
LP7641-6
- System Core
  Tiss
  LP7641-6
- Super System
  NULL
Scale
Ord
LP7751-3
Method
Immune stain
LP6333-1

Basic Attributes

Class: CELLMARK
Type: Laboratory
First Released: Version 2.03
Last Updated: Version 2.73 (MIN)
Change Reason: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Both
Common Test Rank Get Info: 14633

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	CD23 Ag:Přítomnost nebo práh:Časový bod:Tkáně a stěry:Ordinální:Imunobarvení
el-GR	Greek (Greece)	CD23 Αντιγόνο:PrThr:Pt:Ιστός:Ord:Ανοσολογική χρώση Synonyms: CD23 CELLMARK Ord PrThr Pt Ανοσολογική χρώση Αντιγόνο Ιστός
es-AR	Spanish (Argentina)	CD23:concentración arbitraria:punto en el tiempo:tejido, no especificado:ordinal:tinción inmunológica
es-ES	Spanish (Spain)	CD23 Antígeno:PrThr:Punto temporal:Tejido:Ord:Tinción de inmunohistoquímica
es-MX	Spanish (Mexico)	CD23 Ag:Presencia o umbral:Punto temporal:Tejido y frotis:Ordinal:Mancha inmune
et-EE	Estonian (Estonia)	CD23 antigeen:PrThr:Pt:Tis:Ord:Immuunvärv Synonyms: Järgarvuline Juhuslik Kude
fr-CA	French (Canada)	CD23, Ag:Présence-Seuil:Temps ponctuel:Tissu:Ordinal:Coloration immunologique
fr-FR	French (France)	CD23 Ag:Présence/Seuil:Ponctuel:Tissu:Qualitatif:Coloration immune
fr-BE	French (Belgium)	CD23 Ag:PrThr:Temps ponctuel:Tissu:Ordinal:Coloration immunologique Synonyms: Antigène Coloration. Méthode mmunologique
it-IT	Italian (Italy)	CD23, Ag:PrThr:Pt:Tessuto:Ord:Colorazione immunologica Synonyms: Modelli di superficie cellulare Presenza o Soglia Punto nel tempo (episodio) Tessuto & Strisci
ko-KR	Korean (Korea, Republic Of)	CD23 항원:임의농도:검사시점:조직:순위척도:면역염색
nl-NL	Dutch (Netherlands)	CD23 Ag:aanwezigheid:moment:weefsel en uitstrijkjes:ordinaal:immunokleuring Synonyms: antigeen
pl-PL	Polish (Poland)	CD23 Ag:granica wykrywalności:punkt w czasie:tkanka i rozmazy:uporządkowany:barwienie immunohistochemiczne Synonyms: Antygen CD23 CD23
pt-BR	Portuguese (Brazil)	CD23 Ag:ACnc:Pt:Tecido:Ord:Imunocoloração Synonyms: B-6; B6; Leu20; BLAST-2; FceRII; Leu-20; Low affinity IgE receptor; Arbitrary concentration; Point in time; Random; Tissue; Ql; Ordinal; QL; Qualitative; Qual; Screen; ImStn; Immunostain; Immunohistochemical stain; IHC; Antigen; Antigens; Imun; Imune; Imm; CELL MARKERS
ru-RU	Russian (Russian Federation)	CD23 Аг:PrThr:ТчкВрм:Тк:Пор:Иммуногистохимическая окраска Synonyms: Порядковый Ткань и мазки Точка во времени;Момент
tr-TR	Turkish (Turkey)	CD23 Ag:MevcEşik:Zmlı:Doku:Srl:İmmün boyama Synonyms: Antijen Mevcut
zh-CN	Chinese (China)	CD23 抗原:存在情况或阈值:时间点:组织与涂片:序数型:免疫染色法 Synonyms: Ag B6;B-6;BLAST-2;FceRII;Leu20;Leu-20;低亲合力 IgE 受体 CD23 Ag 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型免疫染色;免疫组化;免疫组化染色;免疫组化染色法;免疫组化法;免疫组织化学染色;免疫组织化学染色法;细胞免疫染色;细胞免疫染色法存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）时刻;随机;随意;瞬间未作说明的组织;组织;组织 & 涂片染法染色方法染色法着色着色方法着色法细胞标志物

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.