LOINC
Version 2.67

29647-5Interferon beta Ab [Presence] in Serum or PlasmaActive

Part Descriptions

LP18172-4   Interferon.beta
Beta interferon is a recombinant protein which is chemically identical to or similar to endogenous interferon beta with antiviral and anti-tumor activities. Endogenous interferons beta are cytokines produced by nucleated cells (predominantly natural killer cells) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes with an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral (the most important being inhibition of viral protein synthesis), antiproliferative and immune modulating effects. The recombinant therapeutic forms of interferon beta are interferon beta 1-a and interferon beta 1-b. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: National Cancer Institute, Beta interferon

LP38708-1   Interferon.beta Ab
Highly elevated levels of neutralizing antibodies (NAbs >1:100) to interferon-beta used as therapy in patients with Multiple Sclerosis have been reported to correlate with predictable loss of interferon-beta bioactivity. In patients with elevated NAb levels from >1:20 to <1:100, interferon-beta bioactivity may still be present, but does not necessarily correlate to the exact NAb titer, and continued patient monitoring may be warranted. There is no apparent loss of interferon-beta bioactivity in patients who test positive in the binding antibody assay, but
negative for NAbs; however, continued patient monitoring may also be warranted in this instance as well. Source: Quest Diagnostics Inc., Interferon-beta 1a (IFNB-1a) Antibody

Fully-Specified Name

Component
Interferon.beta Ab
Property
PrThr
Time
Pt
System
Ser/Plas
Scale
Ord
Method

Additional Names

Short Name
IFN-B Ab SerPl Ql
Display Name
Interferon beta Ab Ql

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.03
Last Updated
Version 2.56
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Language Variants Get Info

zh-CNChinese (CHINA)
干扰素.beta 抗体:存在情况或阈值:时间点:血清/血浆:序数型:
nl-NLDutch (NETHERLANDS)
interferon.bèta As:aanwezigheid:moment:serum of plasma:ordinaal:
et-EEEstonian (ESTONIA)
Beetainterferoon antikehad:PrThr:Pt:S/P:Ord:
fr-BEFrench (BELGIUM)
Interféron.béta Ac:PrThr:Temps ponctuel:Sérum/Plasma:Ordinal:
fr-CAFrench (CANADA)
Interféron.bêta , Ac:Présence-Seuil:Temps ponctuel:Sérum/Plasma:Ordinal:
fr-FRFrench (FRANCE)
Interféron bêta anticorps:Présence/Seuil:Ponctuel:Sérum/Plasma:Qualitatif:
de-DEGerman (GERMANY)
Interferon.beta Ak:AKnz:Pkt:Ser/Plas:Ord:
it-ITItalian (ITALY)
Interferone.beta , Ab:PrThr:Pt:Siero/Plasma:Ord:
ko-KRKorean (KOREA, REPUBLIC OF)
인터페론.베타 항체:임의농도:검사시점:혈청/혈장:순위척도:
pt-BRPortuguese (BRAZIL)
Interferon.beta Ac:ACnc:Pt:Sor/Plas:Ord:
ru-RURussian (RUSSIAN FEDERATION)
Интерферон.бета Ат:PrThr:ТчкВрм:Сыв/Плаз:Пор:
es-ARSpanish (ARGENTINA)
anticuerpo contra interferón.beta 1:concentración arbitraria:punto en el tiempo:suero/plasma:ordinal:
es-ESSpanish (SPAIN)
Interferon beta Anticuerpos:PrThr:Punto temporal:Suero o Plasma:Ord:
tr-TRTurkish (TURKEY)
İnterferon.beta Ab:MevcEşik:Zmlı:Ser/Plaz:Srl:

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=29647-5