29874-5

Isovalerylglycine [Presence] in Urine

Active

Part Description

LP14516-6 Isovalerylglycine
Isovalerylglycine is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction: acyl-CoA + glycine < -- > CoA + N-acylglycine Isovalerylglycine is a byproduct of the catabolism of the aminoacid leucine. Accumulation of isovalerylglycine occurs in Isovaleric Acidemia (IVA). IVA (OMIM/ McKusick 243500) is an autosomal recessive disorder caused by mutations in the isovaleryl-CoA dehydrogenase (EC 1.3.99.10) gene. The deficiency of this enzyme in the metabolism of leucine leads to the accumulation of a series of isovaleryl-CoA metabolites, such as isovalerylglycine (IVG). It is very important to caution for false positive results when screening for isovaleric acidemia by tandem mass spectrometry based on dried blood-spot levels of C5-acylcarnitines, including isovalerylcarnitine and its isomer, pivaloylcarnitine; pivaloylcarnitine is derived from pivalate-generating antibiotics, and has caused many false-positive results. PMID: 17850781. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Isovalerylglycine

LOINC Names Get Info

Fully-Specified Name: Isovalerylglycine:PrThr:Pt:Urine:Ord:
Long Common Name: Isovalerylglycine [Presence] in Urine
Short Name: Isovalerylgly Ur Ql
Display Name: Isovalerylglycine Ql (U)
Consumer Name Alpha Get Info: Isovalerylglycine, Urine

Part Model Get Info

Component
Isovalerylglycine
LP14516-6
- Analyte
  Isovalerylglycine
  LP14516-6
  - Component Numerator
    Isovalerylglycine
    LP14516-6
    - Component Numerator Core
      Isovalerylglycine
      LP14516-6
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
PrThr
LP217195-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Urine
LP7681-2
- System Core
  Urine
  LP7681-2
- Super System
  NULL
Scale
Ord
LP7751-3
Method
NULL

Basic Attributes

Class: CHEM
Type: Laboratory
First Released: Version 2.04
Last Updated: Version 2.73 (MIN)
Change Reason: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Observation
Common Test Rank Get Info: 5326

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Izovalerylglycin:Přítomnost nebo práh:Časový bod:Moč:Ordinální:
el-GR	Greek (Greece)	Ισοβαλερυλογλυκίνη:PrThr:Pt:Ούρα:Ord: Synonyms: CHEM Ord PrThr Pt Ισοβαλερυλογλυκίνη Ούρα
es-AR	Spanish (Argentina)	isovalerilglicina:concentración arbitraria:punto en el tiempo:orina:ordinal:
es-MX	Spanish (Mexico)	Isovalerilglicina:Presencia o umbral:Punto temporal:Orina:Ordinal:
es-ES	Spanish (Spain)	Isovalerilglicina:PrThr:Punto temporal:Orina:Ord:
et-EE	Estonian (Estonia)	Isovalerüülglütsiin:PrThr:Pt:U:Ord: Synonyms: Järgarvuline Juhuslik Uriin
fr-CA	French (Canada)	Isovalérylglycine:Présence-Seuil:Temps ponctuel:Urine:Ordinal:
fr-FR	French (France)	Isovalérylglycine:Présence/Seuil:Ponctuel:Urine:Qualitatif:
fr-BE	French (Belgium)	Isovalérylglycine:PrThr:Temps ponctuel:Urine:Ordinal:
it-IT	Italian (Italy)	Isovalerilglicina:PrThr:Pt:Urine:Ord: Synonyms: Chimica Presenza o Soglia Punto nel tempo (episodio)
ko-KR	Korean (Korea, Republic Of)	이소발레릴글리신:임의농도:검사시점:뇨:순위척도:
nl-NL	Dutch (Netherlands)	isovalerylglycine:aanwezigheid:moment:urine:ordinaal:
pl-PL	Polish (Poland)	Izowalerianoglicyna:granica wykrywalności:punkt w czasie:mocz:uporządkowany:
pt-BR	Portuguese (Brazil)	Isovalerilglicina:ACnc:Pt:Urina:Ord: Synonyms: ; Isovalerylgly; Arbitrary concentration; Point in time; Random; Ur; UR; Urn; UA; Ql; Ordinal; QL; Qualitative; Qual; Screen; Chemistry
ru-RU	Russian (Russian Federation)	Изовалерилглицин:PrThr:ТчкВрм:Моча:Пор: Synonyms: Порядковый Точка во времени;Момент
tr-TR	Turkish (Turkey)	İzovalerilglisin:MevcEşik:Zmlı:İdrar:Srl: Synonyms: Mevcut
zh-CN	Chinese (China)	异戊酰甘氨酸:存在情况或阈值:时间点:尿液:序数型: Synonyms: 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）尿;小便;下泉时刻;随机;随意;瞬间

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.