30073-1
Voltage-gated calcium channel Ab [Presence] in Serum
Active
Part Descriptions
LP28510-3 Voltage-gated calcium channel
Voltage-dependent calcium channels (VDCC) are a group of voltage-gated ion channels found in excitable cells (e.g., muscle, glial cells, neurons, etc.) with a permeability to the ion Ca2+.At physiologic or resting membrane potential, VDCCs are normally closed. They are activated (i.e., opened) at depolarized membrane potentials and this is the source of the "voltage-dependent" epithet. Activation of particular VDCCs allows Ca2+ entry into the cell, which, depending on the cell type, results in muscular contraction, excitation of neurons, up-regulation of gene expression, or release of hormones or neurotransmitters.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia
, Wikipedia
LP40151-0 Voltage-gated calcium channel Ab
Voltage gated calcium channel antibody test is used to diagnose Lambert-Eaton myasthenic syndrome, a paraneoplastic syndrome associated with small-cell lung carcinoma.
Source: Quest Diagnostics Inc.
, Voltage-Gated Calcium Channel (VGCC) Ab
LP40151-0 Voltage-gated calcium channel Ab
Lambert-Eaton myasthenic syndrome (LEMS) is a rare autoimmune disorder that is characterised by muscle weakness of the limbs. It is the result of an autoimmune reaction, where antibodies are formed against presynaptic voltage-gated calcium channels in the neuromuscular junction (the connection between nerves and the muscle that they supply). Around 60% of those with LEMS have an underlying malignancy, most commonly small cell lung cancer; it is therefore regarded as a paraneoplastic syndrome (a condition that arises as a result of cancer elsewhere in the body).
In LEMS, antibodies against voltage-gated calcium channels (VGCC), particularly the P/Q-type VGCC, decrease the amount of calcium that can enter the nerve ending, hence less acetylcholine can be mobilized to the neuromuscular junction. Apart from skeletal muscle, the autonomic nervous system also requires acetylcholine neurotransmission; this explains the occurrence of autonomic symptoms in LEMS. P/Q voltage-gated calcium channels are also found in the cerebellum, explaining why some experience problems with coordination. The antibodies bind particularly to the part of the receptor known as the "domain III S5-S6 linker peptide". Antibodies may also bind other VGCCs. Some have antibodies that bind synaptotagmin, a protein involved in calcium-regulated vesicle transport, rather than against VGCC. Many people with LEMS, both with and without VGCC antibodies, have detectable antibodies against the M1 subtype of the acetylcholine receptor; it is thought that their presence participates in a lack of compensation for the slow calcium influx.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia
, Wikipedia
Fully-Specified Name
- Component
- Voltage-gated calcium channel Ab
- Property
- PrThr
- Time
- Pt
- System
- Ser
- Scale
- Ord
- Method
Additional Names
- Long Common Name
- Voltage-gated calcium channel Ab [Presence] in Serum
- Short Name
- VGCC Ab Ser Ql
- Display Name
- Voltage-gated calcium channel Ab Ql (S)
- Consumer Name Alpha Get Info
- Voltage-gated calcium channel antibody, Blood
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 2.04
- Last Updated
- Version 2.73 (MIN)
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 9400
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| el-GR | Greek (Greece) | Τασεο-ελεγχόμενος δίαυλος ασβεστίου Αντίσωμα: Synonyms: PrThr |
| es-AR | Spanish (Argentina) | anticuerpo contra canal de calcio voltaje-dependiente: |
| es-ES | Spanish (Spain) | Canales del Calcio dependientes del voltaje Anticuerpos: |
| es-MX | Spanish (Mexico) | Canal de calcio dependiente de voltaje Ab: |
| fr-CA | French (Canada) | Canaux calciques voltage-dépendants, Ac: |
| fr-FR | French (France) | Canaux calciques voltage dépendants anticorps: |
| fr-BE | French (Belgium) | Canaux calciques voltage-dépendants Ac: Synonyms: Anticorps |
| it-IT | Italian (Italy) | Canale del calcio voltaggio-dipendente Ab: Synonyms: anticorpo Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant |
| ko-KR | Korean (Korea, Republic Of) | 전위 작동 칼슘 통로 항체: |
| nl-NL | Dutch (Netherlands) | voltage-gated calciumkanaal As: Synonyms: antistof; |
| pt-BR | Portuguese (Brazil) | Canal de Cálcio (Voltage-gated) Ac: Synonyms: VGCCA; |
| ru-RU | Russian (Russian Federation) | Потенциал-зависимый кальциевый канал Ат: Synonyms: Антитело Порядковый Сыворотка Точка во времени; |
| tr-TR | Turkish (Turkey) | Voltaj kapılı kalsiyum channel Ab: Synonyms: Mevcut |
| zh-CN | Chinese (China) | 电压门控钙离子通道 抗体: Synonyms: Ab; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
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