30160-6

Tau protein [Mass/volume] in Cerebrospinal Fluid

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Part Descriptions

LP28537-6 Tau protein
CSF tau phosphorylated at threonine 181 (p-tau181) is a widely used biomarker for Alzheimer disease (AD) and has recently been regarded to reflect β-amyloid and/or p-tau deposition in the AD brain. Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disease characterized by intranuclear inclusions in neurons, glial cells, and other somatic cells. Symptoms include dementia, neuropathy, and others. CSF biomarkers were not reported. The objective of this study was to investigate whether CSF biomarkers including p-tau181 are altered in patients with NIID. Source: Máxima MC,

LP28537-6 Tau protein
Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease.

Tau proteins interact with tubulin to stabilize microtubules and promote tubulin assembly into microtubules. Tau has two ways of controlling microtubule stability: isoforms and phosphorylation.

Six tau isoforms exist in brain tissue, and they are distinguished by their number of binding domains. Three isoforms have three binding domains and the other three have four binding domains. The binding domains are located in the carboxy-terminus of the protein and are positively-charged (allowing it to bind to the negatively-charged microtubule). The isoforms with four binding domains are better at stabilizing microtubules than those with three binding domains. The isoforms are a result of alternative splicing in exons 2,3, and 10 of the tau gene.

Phosphorylation of tau is regulated by a host of kinases. For example, PKN, a serine/threonine kinase. When PKN is activated, it phosphorylates tau, resulting in disruption of microtubule organization Taniguchi et al., 2001. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Tau protein

LOINC Names Get Info

Fully-Specified Name: Tau protein:MCnc:Pt:CSF:Qn:
Long Common Name: Tau protein [Mass/volume] in Cerebrospinal Fluid
Short Name: Tau Prot CSF-mCnc
Display Name: Tau protein (CSF) [Mass/Vol]
Consumer Name Alpha Get Info: Tau protein, Spinal fluid

Part Model Get Info

Component
Tau protein
LP28537-6
- Analyte
  Tau protein
  LP28537-6
  - Component Numerator
    Tau protein
    LP28537-6
    - Component Numerator Core
      Tau protein
      LP28537-6
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
MCnc
LP6827-2
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
CSF
LP7156-5
- System Core
  CSF
  LP7156-5
- Super System
  NULL
Scale
Qn
LP7753-9
Method
NULL

Basic Attributes

Class: CHEM
Type: Laboratory
First Released: Version 2.04
Last Updated: Version 2.83 (MIN)
Order vs. Observation: Both
Common Test Rank Get Info: 18045

Member of these Panels

LOINC	Long Common Name
104134-2	Dementia evaluation panel - Cerebrospinal Fluid
97502-9	Prion disease biomarker panel - Cerebrospinal Fluid

Member of these Groups Get Info

LOINC Group	Group Name
LG51449-3	Tau protein\|MCnc\|Pt\|CSF

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Tau protein:Hmotnostní koncentrace:Časový bod:Mozkomíšní mok:Kvantitativní:
de-AT	German (Austria)	Synonyms: Tau Protein /L
de-DE	German (Germany)	Tau-Protein:Massenkonzentration:Zeitpunkt:Liquor:Quantitativ: Synonyms: Zerebrospinalflüssigkeit
el-GR	Greek (Greece)	Πρωτεΐνη Tau:MCnc:Pt:ΕΝΥ:Qn: Synonyms: CHEM MCnc Pt Qn ΕΝΥ Πρωτεΐνη Πρωτεΐνη Tau
es-AR	Spanish (Argentina)	proteína tau:concentración de masa:punto en el tiempo:líquido cefalorraquídeo:cuantitativo:
es-ES	Spanish (Spain)	Proteína Tau:Concentración de masa:Punto temporal:Líquido Cefalorraquideo:Qn: Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Proteína tau:Concentración de masa:Punto temporal:Fluído espinal cerebral:Cuantitativo:
et-EE	Estonian (Estonia)	Tau valk:MCnc:Pt:CSF:Qn: Synonyms: Juhuslik Kvantitatiivne Liikvor
fr-CA	French (Canada)	Protéine Tau:Concentration de masse:Temps ponctuel:LCR:Quantitatif:
fr-FR	French (France)	Protéines Tau:Masse/Volume:Ponctuel:Liquide céphalorachidien:Numérique:
fr-BE	French (Belgium)	Protéine Tau:Concentration de masse:Temps ponctuel:LCR:Quantitatif:
it-IT	Italian (Italy)	Tau, proteina:MCnc:Pt:LCS:Qn: Synonyms: Chimica Concentrazione di Massa Liquido cerebrospinale Proteina Tau Punto nel tempo (episodio)
ko-KR	Korean (Korea, Republic Of)	타우 단백:질량농도:검사시점:뇌척수액:정량:
nl-NL	Dutch (Netherlands)	tau-proteïne:massa/volume:moment:liquor cerebrospinalis:kwantitatief:
pl-PL	Polish (Poland)	Białko Tau:stężenie masowe:punkt w czasie:płyn mózgowo-rdzeniowy:ilościowy:
pt-BR	Portuguese (Brazil)	Proteína Tau:MCnc:Pt:LCR:Qn: Synonyms: ; Tau Prot; Alzheimer disease; PR; Mass concentration; Level; Point in time; Random; Cerebral spinal fluid; Spinal Fluid; Cerebrospinal Fl; Spinal Flu; Spinal Fld; Quantitative; QNT; Quant; Quan; Chemistry
ru-RU	Russian (Russian Federation)	Тау протеин:МассКонц:ТчкВрм:ЦСЖ:Колич: Synonyms: Белок Количественный Массовая концентрация Тау белок Точка во времени;Момент Цереброспинальная жидкость
tr-TR	Turkish (Turkey)	Tau protein:KütlKons:Zmlı:BOS:Kant:
zh-CN	Chinese (China)	Tau 蛋白:质量浓度:时间点:脑脊液:定量型: Synonyms: Alzheimer 病;蛋白 Tau;阿尔茨海默病 CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类可用数量表示的;定量性;数值型;数量型;连续数值型标尺时刻;随机;随意;瞬间水平;浓度;质量浓度(单位体积) 脊液脊髓液脑脊液（Cerebral spinal fluid，CSF）脑脊髓液

Example Units

Unit	Source
pg/mL	Example UCUM Units

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

CodeSystem lookup: https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=30160-6

LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.