30326-3

Cytomegalovirus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

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Part Description

LP14255-1 Cytomegalovirus
Cytomegalovirus is a member of the family Herpesviridae and also known as Human Herpesvirus-5 (HHV-5). It contains a linear double-stranded DNA encased in an icosahedral capsid that is surrounded by a viral envelope. It replicates slowly and may take weeks for the infection to become visible microscopically. Its life cycle includes a lytic and a latent phase. During the lytic phase the cytoskeleton of the infected cell is disrupted and becomes very large. The enlarged cell eludes detection by natural killer (NK) cells by encoding UL16. UL16 is a protein that binds to the ligand NDG2D which is a surface receptor on NK cells and, when blocked, prevents the CMV infected cell from apoptotic signaling to NK cells to destroy it.[https://pedclerk.bsd.uchicago.edu/page/cytomegalovirus-cmv] In the US one in three children are infected by CMV by the age of five and over half of adults are infected by age 40. Infection with CMV is mostly asymptomatic. Symptoms when present include fever, sore throat, fatigue, swollen glands. CMV can occasionally lead to mononucleosis or hepatitis. Immunocompromised patients experience much more acute symptoms that can affect the eyes, lungs, liver, esophagus, stomach, and intestines. For babies born with CMV, involvement with the brain, spleen, lung, liver can occur. In addition, there may be growth problems and hearing loss which is the most common symptom in congenital CMV infection. CMV is transmitted in urine, saliva, blood, tears, semen and breast milk by direct contact. Normally no treatment is necessary, but for severe cases medication is available.[https://www.cdc.gov/cmv/overview.html] Source: Regenstrief LOINC

Fully-Specified Name

Component: Cytomegalovirus DNA
Property: PrThr
Time: Pt
System: CSF
Scale: Ord
Method: Probe.amp.tar

Additional Names

Short Name: CMV DNA CSF Ql NAA+probe
Display Name: CMV DNA NAA+probe Ql (CSF)
Consumer Name Alpha Get Info: Cytomegalovirus (CMV), Spinal fluid

Example Answer List: LL360-9

Source: Regenstrief Institute

Answer	Code	Score	Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)			LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)			LA6577-6

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.04
Last Updated: Version 2.73
Change Reason: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; Updated Answer list type from NORMATIVE to EXAMPLE because the Answers in the list (Positive, Negative) are only examples of possible answers and not an exclusive list
Order vs. Observation: Both
Common Test Rank Get Info: 3868

Member of these Panels

LOINC	Long Common Name
99087-9	Meningitis+Encephalitis pathogens panel - Cerebral spinal fluid by NAA with probe detection

Language Variants Get Info

Tag	Language	Translation
de-AT	German (Austria)	Synonyms: CMV-DNA /L PCR
de-DE	German (Germany)	Cytomegalie-Virus DNA:Nachweis oder Schwellenwert:Zeitpunkt:Liquor:Ordinal:Zielfragmentamplifikation mit Sondendetektion Synonyms: CMV; Zerebrospinalflüssigkeit
es-AR	Spanish (Argentina)	ADN de citomegalovirus:concentración arbitraria:punto en el tiempo:líquido cefalorraquídeo:ordinal:sonda.amplificación.blanco
es-ES	Spanish (Spain)	Citomegalovirus ADN:PrThr:Punto temporal:Líquido Cefalorraquideo:Ord:Sonda con amplificación dirigida
es-MX	Spanish (Mexico)	ADN de citomegalovirus:Presencia o umbral:Punto temporal:Fluído espinal cerebral:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
fr-CA	French (Canada)	Cytomégalovirus , ADN:Présence-Seuil:Temps ponctuel:LCR:Ordinal:Sonde avec amplification de la cible
fr-FR	French (France)	Cytomégalovirus ADN:Présence/Seuil:Ponctuel:Liquide céphalorachidien:Qualitatif:PCR amplification de cible
fr-BE	French (Belgium)	Cytomégalovirus ADN:PrThr:Temps ponctuel:LCR:Ordinal:Sonde avec amplification de la cible Synonyms: CMV
it-IT	Italian (Italy)	Citomegalovirus DNA:PrThr:Pt:LCS:Ord:Sonda.amp.tar Synonyms: Liquido cerebrospinale Microbiologia Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA
ko-KR	Korean (Korea, Republic Of)	거대세포바이러스 디옥시리보핵산:임의농도:검사시점:뇌척수액:순위척도:DNA 탐색자.증폭.표적
nl-NL	Dutch (Netherlands)	Cytomegalovirus DNA:aanwezigheid:moment:liquor cerebrospinalis:ordinaal:probe-detectie Synonyms: probe.amp.tar
pt-BR	Portuguese (Brazil)	Citomegalovírus DNA:ACnc:Pt:LCR:Ord:Sonda com limite de detecção da amplificação de alvo Synonyms: Deoxyribonucleic acid; CMV; Cytomgal; Cytomegalo virus; Arbitrary concentration; Point in time; Random; Cerebral spinal fluid; Spinal Fluid; Cerebrospinal Fl; Spinal Flu; Spinal Fld; Ql; Ordinal; QL; Qualitative; Qual; Screen; PCR; Polymerase chain reaction; Transcription mediated amplification; NASBA; Nucleic acid sequence based analysis; SDA; Strand Displacement Amplification; LAT; Ligation-activated transcription; 3SR SR; 3 Self-Sustaining Sequence Replication; LCR; Ligase chain reaction; QBR; Q-Beta Replicase or probe amplification category method; Probe with target amplification; NAAT; TMA; Amp Prb; Probe with ampification; DNA probe; Amplified; Microbiology
ru-RU	Russian (Russian Federation)	Цитомегаловирус ДНК:PrThr:ТчкВрм:ЦСЖ:Пор:Проба.усил.миш Synonyms: ДНК проба;ДНК зонд Порядковый Проба с мишени усилением Точка во времени;Момент Цереброспинальная жидкость
tr-TR	Turkish (Turkey)	Cytomegalovirus DNA:MevcEşik:Zmlı:BOS:Srl:Prob.amf.hdf Synonyms: Mevcut
zh-CN	Chinese (China)	巨细胞病毒 DNA:存在情况或阈值:时间点:脑脊液:序数型:探针法.基因扩增.靶向 Synonyms: CMV DNA CMV;涎腺病毒;细胞巨化病毒;细胞肥大病毒 CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型借助扩增的探针方法;借助扩增的探针法;探针法.扩增借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向去氧核糖核酸;脱氧核糖核酸去氧核糖核酸;脱氧核糖核酸;脱氧核糖核酸（Deoxyribonucleic acid，DNA）存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）扩增型扩增性时刻;随机;随意;瞬间经过扩增的脊液脊髓液脑脊液（Cerebral spinal fluid，CSF）脑脊髓液脱氧核糖核酸探针

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