31149-8
P53 protein Ag/cells in Tissue by Immune stain
Active
Part Description
LP18603-8 P53 protein
The p53 antigen was first discovered in 1979 and recognized as a tumor repressive gene in 1989. It encodes a protein that monitors the cell cycle by suppressing tumor growth and preventing genome mutation. When p53 is defective, abnormal cell proliferation can occur. Mutations in p53 are present in up to 50% of all human tumors. The three major functions of p53 include growth arrest, DNA repair, and apoptosis. P53 halts the growth arrest function of the cell cycle progress which can activate transcription of proteins that repair DNA. There are low levels of p53 in normal cells, but damage to DNA and similar stress signals may precipitate an increase of p53 protein. Cell death is the final course of action to prevent cells containing abnormal DNA from dividing. The concentration of P53 in cells is probably tightly controlled since high concentrations may accelerate aging due to excess apoptosis.
[http://www.bioinformatics.org/p53/introduction.html] Ongoing studies are investigating the utility of the p53 antibody being used as a biomarker for the early detection of lung cancer in high risk asymptomatic patients. PMID: 21733826
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- P53 protein Ag/Cells
- Property
- NFr
- Time
- Pt
- System
- Tiss
- Scale
- Qn
- Method
- Immune stain
Additional Names
- Long Common Name
- P53 protein Ag/cells in Tissue by Immune stain
- Short Name
- P53 protein Ag NFr Tiss ImStn
- Display Name
- P53 protein Ag/cells Immune stain (Tiss)
- Consumer Name Alpha Get Info
- P53 protein/cells, Tissue
Basic Attributes
- Class
- PATH
- Type
- Laboratory
- First Released
- Version 2.07
- Last Updated
- Version 2.79 (NAM)
- Change Reason
- Release 2.79: COMPONENT: Triggered by Coll w SCT: This is a specific fraction case where the denominator is percentage or /100. Because the logic is that the percentage piece is captured by Property: NFr (Numeric Fraction), and by Unit: %, therefore, it is redundant to include "100" in the component;
- Order vs. Observation
- Both
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| el-GR | Greek (Greece) | Πρωτεΐνη P53 Αντιγόνο/κύτταρα: Synonyms: NFr p53 Κύτταρα Πρωτεΐνη Πρωτεΐνη P53 |
| es-AR | Spanish (Argentina) | antígeno de proteína p53/100 células: |
| es-ES | Spanish (Spain) | Proteína p53 Antígeno/células: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Proteína P53 Ag / 100 células: |
| fr-CA | French (Canada) | Protéine P53, Ag/Cellules: |
| fr-FR | French (France) | Protéine P53 antigène/100 cellules: |
| it-IT | Italian (Italy) | P53, proteina, Ag/cellule: Synonyms: Frazione numerica Patologia Proteina P53 Punto nel tempo (episodio) Tessuto & |
| ko-KR | Korean (Korea, Republic Of) | P53 단백 항원/100 세포: |
| nl-NL | Dutch (Netherlands) | p53-eiwit Ag/cellen: Synonyms: antigeen |
| pt-BR | Portuguese (Brazil) | P53 proteína Ag/100 células: Synonyms: ; |
| ru-RU | Russian (Russian Federation) | P53 протеин Аг/клетки: Synonyms: Белок Количественный Количество отношение Ткань и мазки Точка во времени; |
| tr-TR | Turkish (Turkey) | P53 protein Ag/Hücreler: |
| zh-CN | Chinese (China) | P53 蛋白 抗原/细胞: Synonyms: Ag Oncogene Protein Ag p53 抗癌基因蛋白; |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=31149-8
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