33048-0
Eosin-5-Maleimide binding [Presence] in Blood by Flow cytometry (FC)
Active
Term Description
Patients with hereditary spherocytosis have a decreased fluorescence intensity compared to normal patients.
Source: Regenstrief LOINC
Part Description
LP30813-7 Eosin-5-Maleimide binding
Eosin-5-maleimide (EMA) is a fluorescent dye used in flow cytometry to screen for hereditary spherocytosis (HS). Patients with HS have red blood cells (RBC) that are overly rigid and misshapen and are removed by the spleen for destruction which leads to anemia, jaundice and splenomegaly. EMA binds covalently to Lys-430 on the first extracellular loop of the Band 3 protein on RBCs. The cytoplasmic portion of Band 3 communicates with ankyrin and protein 4.2 that are crosslinked with the spectrin-based cytoskeleton that acts to stabilize the cell membrane. When band 3 is deficient or abnormal on RBCs fluorescence using EMA may be reduced. The mean fluorescent intensity (MFI) of the patient and control cells is measured and the result is expressed as a ratio of patient MFI to control MFI.[Dacie and Lewis Practical Haematology, 11th edition, Barbara J. Bain, Imelda Bates, Mike A. Laffan, S. Mitchell Lewis, pp250-251]MedlinePlus Condition: hereditary-spherocytosis]
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Eosin-5-Maleimide binding
- Property
- PrThr
- Time
- Pt
- System
- Bld
- Scale
- Ord
- Method
- Flow cytometry
Additional Names
- Long Common Name
- Eosin-5-Maleimide binding [Presence] in Blood by Flow cytometry (FC)
- Short Name
- EMA Bind Bld Ql FC
- Display Name
- Eosin-5-Maleimide binding FC Ql (Bld)
- Consumer Name Alpha Get Info
- Eosin-5-Maleimide binding, Blood
Basic Attributes
- Class
- HEM/BC
- Type
- Laboratory
- First Released
- Version 2.09
- Last Updated
- Version 2.73
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Observation
- Common Test Rank Get Info
- 7250
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-AR | Spanish (Argentina) | fijación de eosina-5-maleimida: |
| es-ES | Spanish (Spain) | fijación de eosina-5-maleimida: |
| es-MX | Spanish (Mexico) | Unión de eosina-5-maleimida: |
| fr-CA | French (Canada) | Liaison à l'éosine-5-maléimide: |
| fr-FR | French (France) | Éosine-5-Maléimide liée: |
| fr-BE | French (Belgium) | Liaison à l'éosine-5-maléimide: |
| it-IT | Italian (Italy) | Eosina-5-Maleimide legante: Synonyms: Citometria a flusso (FC) Ematologia (coagulazione) conta differenziale Presenza o Soglia Punto nel tempo (episodio) Sangue |
| ko-KR | Korean (Korea, Republic Of) | 에오신-5-말레이미드 결합: |
| nl-NL | Dutch (Netherlands) | eosine-5-maleïmide binding: |
| pt-BR | Portuguese (Brazil) | Ligação da Eosina-5-Maleimida: Synonyms: ; |
| ru-RU | Russian (Russian Federation) | Эозин-5-малеимид связывание: Synonyms: Кровь Порядковый Точка во времени; |
| tr-TR | Turkish (Turkey) | Eosin-5-Maleimid bağlayıcı: Synonyms: Akış hücremetresi Mevcut |
| zh-CN | Chinese (China) | 伊红-5-马来酰亚胺结合: Synonyms: EMA; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
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LOINC Copyright
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