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Term Description

Abeta 42 level is elevated in individuals whose chromosomes carry the genetic mutations characteristic of the early form of Alzheimer's.

Part Descriptions

LP30823-6   Amyloid beta 42 peptide
Abeta 42 level is elevated in individuals whose chromosomes carry the genetic mutations characteristic of the early form of Alzheimer's. Source: Regenstrief Institute

LP30823-6   Amyloid beta 42 peptide
Amyloid beta (Aβ or Abeta) is a peptide of 36-43 amino acids that is processed from the Amyloid precursor protein. While it is most commonly known in association with Alzheimer's disease, it does not exist specifically to cause disease. Evidence has been found that Aβ has multiple non-disease activities.

The most common isoforms are Aβ40 and Aβ42; the shorter form is typically produced by cleavage that occurs in the endoplasmic reticulum, while the longer form is produced by cleavage in the trans-Golgi network. The Aβ40 form is the more common of the two, but Aβ42 is the more fibrillogenic and is thus associated with disease states. Mutations in APP associated with early-onset Alzheimer's have been noted to increase the relative production of Aβ42, and thus one suggested avenue of Alzheimer's therapy involves modulating the activity of β and γ secretases to produce mainly Aβ40.

Increases in either total Aβ levels or the relative concentration of both Aβ40 and Aβ42 (where the former is more concentrated in cerebrovascular plaques and the latter in neuritic plaques) have been implicated in the pathogenesis of both familial and sporadic Alzheimer's disease. Due to its more hydrophobic nature, the Aβ42 is the most amyloidogenic form of the peptide. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

LOINC Names Get Info

Fully-Specified Name
Amyloid beta 42 peptide:MCnc:Pt:Plas:Qn:
Long Common Name
Amyloid beta 42 peptide [Mass/volume] in Plasma
Short Name
AL beta42 Plas-mCnc
Display Name
Amyloid beta 42 peptide (P) [Mass/Vol]
Consumer Name Alpha Get Info
Amyloid beta 42 peptide, Blood

Part Model Get Info

  • Component
    Amyloid beta 42 peptide
    LP30823-6
    • Analyte
      Amyloid beta 42 peptide
      LP30823-6
      • Component Numerator
        Amyloid beta 42 peptide
        LP30823-6
        • Component Numerator Core
          Amyloid beta 42 peptide
          LP30823-6
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    MCnc
    LP6827-2
  • Time
    Pt
    LP6960-1
  • System
    Plas
    LP7479-1
    • System Core
      Plas
      LP7479-1
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    NULL
     

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.09
Last Updated
Version 2.42 (MIN)
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Amyloid-beta 42 peptid:Hmotnostní koncentrace:Časový bod:Plazma:Kvantitativní:
el-GRGreek (Greece)β-αμυλοειδές πεπτίδιο 42:MCnc:Pt:Πλάσμα:Qn:
Synonyms: CHEM MCnc Pt Qn β-αμυλοειδές πεπτίδιο 42 Πλάσμα
es-ARSpanish (Argentina)péptido amiloide beta 42:concentración de masa:punto en el tiempo:suero:cuantitativo:
es-ESSpanish (Spain)Péptido beta amiloide 42:Concentración de masa:Punto temporal:Plasma:Qn:
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Péptido beta 42 amiloide:Concentración de masa:Punto temporal:Plasma:Cuantitativo:
fr-CAFrench (Canada)Peptide amyloïde bêta 42:Concentration de masse:Temps ponctuel:Plasma:Quantitatif:
fr-FRFrench (France)Peptide bêta amyloïde 1-42:Masse/Volume:Ponctuel:Plasma:Numérique:
fr-BEFrench (Belgium)Peptide amyloïde béta 42:Concentration de masse:Temps ponctuel:Plasma:Quantitatif:
it-ITItalian (Italy)Amiloide beta 42 peptide:MCnc:Pt:Plasma:Qn:
Synonyms: Chimica Concentrazione di Massa Plasma Punto nel tempo (episodio)
ko-KRKorean (Korea, Republic Of)아밀로이드 베타 42 펩티드:질량농도:검사시점:혈청:정량:
nl-NLDutch (Netherlands)amyloïd-bèta-42-peptide:massa/volume:moment:plasma:kwantitatief:
Synonyms: amyloid beta 42 peptide
pl-PLPolish (Poland)Peptyd amyloidu beta 42:stężenie masowe:punkt w czasie:osocze:ilościowy:
pt-BRPortuguese (Brazil)Beta amilóide 42 peptídeo:MCnc:Pt:Soro:Qn:
Synonyms: ; AL beta42; Alzheimer disease; Aceta 42; Beta-amyloid; Ac42 peptide; Mass concentration; Level; Point in time; Random; Serum; SR; Quantitative; QNT; Quant; Quan; Pept; B; Chemistry
ru-RURussian (Russian Federation)Амилоид бета 42 пептид:МассКонц:ТчкВрм:Плаз:Колич:
Synonyms: Количественный Массовая концентрация Плазма Точка во времени;Момент
tr-TRTurkish (Turkey)Amiloid beta 42 peptid:KütlKons:Zmlı:Plaz:Kant:
zh-CNChinese (China)淀粉样蛋白 Beta 42 肽:质量浓度:时间点:血浆:定量型:
Synonyms: Ab42 peptide;Ab42 肽;Abeta 42;AL beta42;Alzheimer 氏病;Alzheimer 病;Alzheimer氏病;Alzheimer病;Beta 淀粉样肽;Beta-淀粉样肽;Beta-淀粉样蛋白;Beta-淀粉状朊;Beta-淀粉状蛋白;β淀粉样肽;β-淀粉样肽;β-淀粉样蛋白;β-淀粉状朊;β-淀粉状蛋白;淀粉状蛋白 Beta 42 肽;淀粉样蛋白β42 肽;淀粉状朊 Beta 42 肽;淀粉状朊β42 肽;淀粉状蛋白β42 肽;老年性痴呆;老年痴呆;阿尔茨海默病 B β β淀粉样蛋白;淀粉样β蛋白 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 水平;浓度;质量浓度(单位体积) 淀粉样蛋白 淀粉状朊 硫酸胶化纤维素 类淀粉物 缩氨酸 胶化纤维素 贝塔

Example Units

UnitSource
pg/mLExample UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=33200-7