LOINC
Version 2.69

33367-4Lactate dehydrogenase [Enzymatic activity/volume] in Pericardial fluidDiscouraged

Status Information

Status
Discouraged
Comment
Because there is a 3-fold difference in normal range between L>P and P>L methods, the use of the methodless term is not recommended.
Map-To Long Common Name Mapping Guidance
60019-7 Lactate dehydrogenase [Enzymatic activity/volume] in Pericardial fluid by Lactate to pyruvate reaction
60018-9 Lactate dehydrogenase [Enzymatic activity/volume] in Pericardial fluid by Pyruvate to lactate reaction

Part Descriptions

LP15033-1   Lactate dehydrogenase
Lactate dehydrogenase (LDH) is an enzyme (EC 1.1.1.27) present in a wide variety of organisms, including plants and animals. It catalyses the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+. As it can also catalyze the oxidation of hydroxybutyrate, it is occasionally called hydroxybutyrate dehydrogenase (HBD). Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, D-lactate (Wikipedia)

LP15033-1   Lactate dehydrogenase
Lactate dehydrogenase (LDH, or also called LD) is an oxidoreductase (LD: EC 1.1.1.27) and is the most important clinically of several dehydrogenases occurring in human serum. LDH catalyses the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD. When disease, injury, or toxic material damages tissues, cells release LDH into the bloodstream. Since LDH is a fairly stable enzyme, it has been widely used to evaluate the presence of damage and toxicity of tissue and cells. LDH is cytoplasmic in its cellular location and in any one tissue is composed of one or two of five possible isoenzymes. While many of its clinical applications involve quantification of one or more specific serum isoenzymes, an estimate of total LDH is usually required. Lactate dehydrogenase catalyzes the reversible reaction: L-lactate + NAD <--> pyruvate + NADH. Testing methods either measure the increase in NADH produced in the lactate-to-pyruvate reaction or the decrease in NADH produced in the pyruvate-to-lactate reaction. [PMID: 3882046] . Reference ranges are highly method dependent. The pyruvate-to-lactate reaction is preferred theoretically because the equilibrium constant is large and the rate for any amount of enzyme is 2-3 times faster, thus smaller sample and shorter observation periods are needed. Disadvantages of the pyruvate-to-lactate reaction are loss of linearity as compared with the lactate-to-pyruvate reaction, and greater substrate inhibition of the enzyme. [Tietz Fourth Edition] Source: Regenstrief LOINC

Fully-Specified Name

Component
Lactate dehydrogenase
Property
CCnc
Time
Pt
System
Pericard fld
Scale
Qn
Method

Additional Names

Short Name
LDH Pcar-cCnc
Display Name
LDH (Pericard fld) [Catalytic activity/Vol]
Consumer Name Alpha
Lactate Dehydrogenase (LDH), Pericardial Fluid

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.09
Last Updated
Version 2.68
Order vs. Observation
Both

Reference Information

Type Source Reference
Webcontent Lab Tests Online®Copyright Copyright © 2001-2019 American Association for Clinical Chemistry Lactate Dehydrogenase (LD)

Language Variants Get Info

zh-CNChinese (China)
乳酸脱氢酶:催化浓度:时间点:心包液:定量型:
nl-NLDutch (Netherlands)
lactaatdehydrogenase:enzymatische activiteit/volume:moment:pericardvocht:kwantitatief:
et-EEEstonian (Estonia)
Laktaadi dehüdrogenaas:CCnc:Pt:PrcF:Qn:
fr-BEFrench (Belgium)
Lactate déshydrogénase:Concentration catalytique:Temps ponctuel:Liquide péricardique:Quantitatif:
fr-CAFrench (Canada)
Lactate déshydrogénase:Concentration catalytique:Temps ponctuel:Liquide péricardique:Quantitatif:
de-DEGerman (Germany)
Lactatdehydrogenase:KKnz:Pkt:Perikard Fl:Qn:
it-ITItalian (Italy)
Lattato deidrogenasi:CCnC:Pt:Liquido pericardico:Qn:
ko-KRKorean (Korea, Republic of)
젖산 탈수소효소:촉매농도:검사시점:심낭액:정량:
pt-BRPortuguese (Brazil)
Desidrogenase Láctica:CCnc:Pt:LiqPeric:Qn:
ru-RURussian (Russian Federation)
Лактатдегидрогеназа:КаталКонц:ТчкВрм:Перикардиальная ждк:Колич:
es-ARSpanish (Argentina)
lactato deshidrogenasa:concentración catalítica:punto en el tiempo:líquido pericárdico:cuantitativo:
es-ESSpanish (Spain)
Lactato deshidrogenasa:Concentración Catalítica:Punto temporal:Fluido pericárdico:Qn:
tr-TRTurkish (Turkey)
Laktat dehidrojenaz:KtlKons:Zmlı:Perikard sv:Kant:

Example Units

Unit Source
U/L Example UCUM Units
U/L Original Submission

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=33367-4