33571-1
Jo-1 extractable nuclear IgG Ab [Units/volume] in Serum
Active
Part Description
LP16719-4 Jo-1 extractable nuclear
Aminoacyl-tRNA synthetases (ARS) are enzymes that link amino acids to tRNA molecules and therefore play a key role in protein synthesis. Each ARS is specific for a single amino acid. [NCBI Books: NBK22356] Autoantibodies to ARS are a hallmark of connective tissue diseases including anti-synthetase syndrome (ASS) and idiopathic inflammatory myopathies such as polymyositis (PM) and dermatomyositis (DM). ASS, PM and DM have overlapping features, including myositis, arthralgia, skin manifestations and interstitial lung disease. Antibodies to several specific ARS enzymes have been identified, including anti-histidyl (anti-Jo-1), anti-threonyl (anti-PL-7), anti-alanyl (anti-PL-12), anti-glycyl (anti-Ej), anti-isoleucyl (anti-Oj), anti-asparaginyl (anti-Ks), anti-phenylalanyl (anti-Zo), and anti-tyrosyl (anti-Ha). Different antibodies or patterns of antibodies have been associated with specific clinical features. Anti-Jo-1, anti-Ej, and anti-PL-7 antibodies are associated with myositis, including classic DM, clinically amyopathic DM (CADM) and PM. Anti-PL-12 alone is associated with CADM or interstitial lung disease (ILD). Anti-Ej and anti-PL-12 together are associated with CADM. Anti-Ks and anti-Oj are associated with ILD alone. PMID: 23573256 Anti-Ha and anti-Zo antibodies are the most recent autoantibodies to be identified in patients with symptoms of ASS. PMID: 17392287 Identifying the particular anti-ARS antibodies associated with an individual patient's disease may help guide treatment and predict clinical outcomes.
Source: Regenstrief LOINC, PMID: 23573256
Fully-Specified Name
- Component
- Jo-1 extractable nuclear Ab.IgG
- Property
- ACnc
- Time
- Pt
- System
- Ser
- Scale
- Qn
- Method
Additional Names
- Short Name
- ENA Jo1 IgG Ser-aCnc
- Display Name
- Jo-1 extractable nuclear IgG Qn (S)
- Consumer Name Alpha Get Info
- Jo-1 extractable nuclear IgG antibody, Blood
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 2.09
- Last Updated
- Version 2.73
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 3192
Member of these Panels
LOINC | Long Common Name |
---|---|
95267-1 | Connective tissue autoimmune IgG panel - Serum or Plasma |
90228-8 | Extractable nuclear antigen Ab.IgG panel - Serum |
97564-9 | Nuclear antibody panel - Serum |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-AR | Spanish (Argentina) | [anticuerpo] antinuclear extraíble JO-1 [Ac].IgG [Inmunoglobulina G]: |
es-ES | Spanish (Spain) | Jo-1 IgG: Synonyms: Cuantitativo |
es-MX | Spanish (Mexico) | Ab.IgG nuclear extraíble con Jo-1: |
fr-CA | French (Canada) | Jo-1 nucléaire soluble, IgG: |
fr-FR | French (France) | Jo-1 anticorps IgG: |
fr-BE | French (Belgium) | Jo-1 nucléaire soluble Anticorps. IgG: Synonyms: Anticorps |
it-IT | Italian (Italy) | Jo-1, nucleare estraibile Ab.IgG: Synonyms: anticorpi IgG anticorpo Concentrazione Arbitraria ENA Jo1 Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant |
ko-KR | Korean (Korea, Republic Of) | Jo-1 추출성 핵 항체.면역글로불린 G: |
nl-NL | Dutch (Netherlands) | jo-1 extraheerbaar nucleair As.IgG: Synonyms: antistof; |
pl-PL | Polish (Poland) | Jo-1 rozpuszczalny jądrowy Ab.IgG: Synonyms: IgG Jo-1 rozpuszczalny jądrowy Przeciwciała do rozpuszczalnego antygenu jądrowego Przeciwciała do rozpuszczalnego jądrowego antygenu Jo-1 Przeciwciała IgG do jądra komórkowego Przeciwciała IgG do rozpuszczalnego jądrowego antygenu Jo-1 Przeciwciała przeciwjądrowe |
pt-BR | Portuguese (Brazil) | Jo-1 Ac.IgG: Synonyms: ; |
ru-RU | Russian (Russian Federation) | Jo-1 экстрагируемый ядерный Ат.IgG: Synonyms: Антитело Количественный Произвольная концентрация Сыворотка Точка во времени; |
tr-TR | Turkish (Turkey) | Jo-1 öztlenebilir çekirdek Ab.IgG: Synonyms: Ak Ak.IgG Çekirdek |
uk-UA | Ukrainian (Ukraine) | Jo-1 екстрагований ядерний Антитіла.IgG: Synonyms: ABS; |
zh-CN | Chinese (China) | Jo-1 可提取性核 抗体.IgG: Synonyms: Ⅰ Ab.IgG; |
Example Units
Unit | Source |
---|---|
AU/mL | REGENSTRIEF |
Index | REGENSTRIEF |
units | REGENSTRIEF |
[arb'U]/mL | Example UCUM Units |
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