Version 2.77

Part Descriptions

LP16902-6   Platelet factor 4
A high-molecular-weight proteoglycan-platelet factor complex which is released from blood platelets by thrombin. It acts as a mediator in the heparin-neutralizing capacity of the blood and plays a role in platelet aggregation. At high ionic strength (I=0.75), the complex dissociates into the active component (molecular weight 29,000) and the proteoglycan carrier (chondroitin 4-sulfate, molecular weight 350,000). The molecule exists in the form of a dimer consisting of 8 moles of platelet factor 4 and 2 moles of proteoglycan. Source: National Library of Medicine, MeSH 2006

LP16902-6   Platelet factor 4
Platelet factor-4 (PF4) is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major role is to neutralize heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 may play a role in inflammation and wound repair. The heparin:PF4 complex is the immunogen in heparin-induced thrombocytopenia, an idiosyncratic autoimmune reaction that sometimes occurs following the injection of heparin. PF4 autoantibodies have also been observed in patients with thrombosis and features resembling HIT although these patients did not receive heparin. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

Reference Information

Type Source Reference
Mapping Guidance Regenstrief Help PF4 is used clinically to assess degree of platelet activation but specimen has to be collected meticulously. Some labs use PD4 as short hand for Heparin induced platelet Ab so be careful about mapping. Mapper’s Guide for the Top 2000 plus LOINC Laboratory Observations

Fully-Specified Name

Component
Platelet factor 4
Property
PrThr
Time
Pt
System
PPP
Scale
Ord
Method

Additional Names

Short Name
PF4 PPP Ql
Display Name
Platelet factor 4 Ql (PPP)
Consumer Name Alpha Get Info
Platelet factor 4, Blood

Example Answer List: LL360-9

Source: Regenstrief Institute
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
COAG
Type
Laboratory
First Released
Version 2.09
Last Updated
Version 2.73
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both
Common Test Rank Get Info
4476

Language Variants Get Info

Tag Language Translation
es-AR Spanish (Argentina) factor 4 plaquetario:concentración arbitraria:punto en el tiempo:plasma desplaquetado:ordinal:
es-ES Spanish (Spain) Factor plaquetario 4:PrThr:Punto temporal:Plasma pobre en plaquetas:Ord:
es-MX Spanish (Mexico) Factor plaquetario 4:Presencia o umbral:Punto temporal:Plasma pobre en plaquetas:Ordinal:
et-EE Estonian (Estonia) Trombotsüütide 4. faktor:PrThr:Pt:PPP:Ord:
Synonyms: Järgarvuline Juhuslik Trombotsüütidevaene plasma
fr-CA French (Canada) Facteur 4 plaquettaire:Présence-Seuil:Temps ponctuel:Plasma pauvre en plaquettes:Ordinal:
fr-FR French (France) Facteur 4 plaquettaire:Présence/Seuil:Ponctuel:Plasma pauvre en plaquettes:Qualitatif:
fr-BE French (Belgium) Facteur 4 plaquettaire:PrThr:Temps ponctuel:Plasma pauvre en plaquettes:Ordinal:
Synonyms: PF4
it-IT Italian (Italy) Fattore piastrinico 4:PrThr:Pt:PPP:Ord:
Synonyms: Piastrine Plasma povero di piastrine Presenza o Soglia Punto nel tempo (episodio) Studio di coagulazione
ko-KR Korean (Korea, Republic Of) 혈소판 제4 인자:임의농도:검사시점:혈소판제거혈장:순위척도:
nl-NL Dutch (Netherlands) plaatjes factor 4:aanwezigheid:moment:plaatjesarm plasma:ordinaal:
Synonyms: coagulatiemethode
pl-PL Polish (Poland) Czynnik płytkowy 4:granica wykrywalności:punkt w czasie:osocze ubogopłytkowe:półilościowy:
Synonyms: Czynnik płytkowy PPP
pt-BR Portuguese (Brazil) Fator plaquetário 4:ACnc:Pt:PPPQ:Ord:
Synonyms: ; PF4; Heparin-Induced Platelet Ac; PI-factor 4; Platelet type heparin inactivator; PF; Plt; Pl; Platelets; Thrombocytes; Platelt; Thrombocyte; Arbitrary concentration; Point in time; Random; Platelet poor plasma; Plas; Ql; Ordinal; QL; Qualitative; Qual; Screen; Fac; Fact; COAGULATION
ru-RU Russian (Russian Federation) Пластинка фактор 4:PrThr:ТчкВрм:ОПП:Пор:
Synonyms: Обеднённая пластинками плазма;Бедная тромбоцитами плазма Порядковый Точка во времени;Момент Тромбоцит Тромбоцитарный фактор 4
tr-TR Turkish (Turkey) Trombosit faktör 4:MevcEşik:Zmlı:TFkP:Srl:
Synonyms: Mevcut
zh-CN Chinese (China) 血小板因子 4:存在情况或阈值:时间点:贫血小板血浆:序数型:
Synonyms: PF4;PI-因子 4;肝素诱导型血小板 AB(Heparin-Induced Platelet AB);血小板因子 4(Platelet factor 4,PF4);血小板型肝素灭活剂(Platelet type heparin inactivator) 乏血小板血浆;Platelet poor plasma;PPP 依次型;分类顺序型;定性的;序数型(或称等级型);性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 凝血功能;凝血功能试验;凝血过程;血液凝固;血液凝固功能;血液凝固过程 因素 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况(存在、存在与否、是否存在)或阈值(界值、界限、阀值、临界值) 时刻;随机;随意;瞬间 系数 血栓细胞

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=33594-3