33594-3
Platelet factor 4 [Presence] in Platelet poor plasma
Active
Part Descriptions
LP16902-6 Platelet factor 4
A high-molecular-weight proteoglycan-platelet factor complex which is released from blood platelets by thrombin. It acts as a mediator in the heparin-neutralizing capacity of the blood and plays a role in platelet aggregation. At high ionic strength (I=0.75), the complex dissociates into the active component (molecular weight 29,000) and the proteoglycan carrier (chondroitin 4-sulfate, molecular weight 350,000). The molecule exists in the form of a dimer consisting of 8 moles of platelet factor 4 and 2 moles of proteoglycan.
Source: National Library of Medicine, MeSH 2006
LP16902-6 Platelet factor 4
Platelet factor-4 (PF4) is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major role is to neutralize heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 may play a role in inflammation and wound repair. The heparin:PF4 complex is the immunogen in heparin-induced thrombocytopenia, an idiosyncratic autoimmune reaction that sometimes occurs following the injection of heparin. PF4 autoantibodies have also been observed in patients with thrombosis and features resembling HIT although these patients did not receive heparin.
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Source: Wikipedia, Wikipedia
Reference Information
| Type | Source | Reference |
|---|---|---|
| Mapping Guidance | Regenstrief Help | PF4 is used clinically to assess degree of platelet activation but specimen has to be collected meticulously. Some labs use PD4 as short hand for Heparin induced platelet Ab so be careful about mapping. Mapper’s Guide for the Top 2000 plus LOINC Laboratory Observations |
Fully-Specified Name
- Component
- Platelet factor 4
- Property
- PrThr
- Time
- Pt
- System
- PPP
- Scale
- Ord
- Method
Additional Names
- Short Name
- PF4 PPP Ql
- Display Name
- Platelet factor 4 Ql (PPP)
- Consumer Name Alpha Get Info
- Platelet factor 4, Blood
Example Answer List: LL360-9
Source: Regenstrief Institute| Answer | Code | Score | Answer ID |
|---|---|---|---|
| PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
| NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 |
Basic Attributes
- Class
- COAG
- Type
- Laboratory
- First Released
- Version 2.09
- Last Updated
- Version 2.73
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 4476
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-AR | Spanish (Argentina) | factor 4 plaquetario: |
| es-ES | Spanish (Spain) | Factor plaquetario 4: |
| es-MX | Spanish (Mexico) | Factor plaquetario 4: |
| et-EE | Estonian (Estonia) | Trombotsüütide 4. faktor: Synonyms: Järgarvuline Juhuslik Trombotsüütidevaene plasma |
| fr-CA | French (Canada) | Facteur 4 plaquettaire: |
| fr-FR | French (France) | Facteur 4 plaquettaire: |
| fr-BE | French (Belgium) | Facteur 4 plaquettaire: Synonyms: PF4 |
| it-IT | Italian (Italy) | Fattore piastrinico 4: Synonyms: Piastrine Plasma povero di piastrine Presenza o Soglia Punto nel tempo (episodio) Studio di coagulazione |
| ko-KR | Korean (Korea, Republic Of) | 혈소판 제4 인자: |
| nl-NL | Dutch (Netherlands) | plaatjes factor 4: Synonyms: coagulatiemethode |
| pl-PL | Polish (Poland) | Czynnik płytkowy 4: Synonyms: Czynnik płytkowy PPP |
| pt-BR | Portuguese (Brazil) | Fator plaquetário 4: Synonyms: ; |
| ru-RU | Russian (Russian Federation) | Пластинка фактор 4: Synonyms: Обеднённая пластинками плазма; |
| tr-TR | Turkish (Turkey) | Trombosit faktör 4: Synonyms: Mevcut |
| zh-CN | Chinese (China) | 血小板因子 4: Synonyms: PF4; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=33594-3
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