Version 2.73

33594-3Platelet factor 4 [Presence] in Platelet poor plasmaActive

Part Descriptions

LP16902-6   Platelet factor 4
A high-molecular-weight proteoglycan-platelet factor complex which is released from blood platelets by thrombin. It acts as a mediator in the heparin-neutralizing capacity of the blood and plays a role in platelet aggregation. At high ionic strength (I=0.75), the complex dissociates into the active component (molecular weight 29,000) and the proteoglycan carrier (chondroitin 4-sulfate, molecular weight 350,000). The molecule exists in the form of a dimer consisting of 8 moles of platelet factor 4 and 2 moles of proteoglycan. Source: National Library of Medicine, MeSH 2006

LP16902-6   Platelet factor 4
Platelet factor-4 (PF4) is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major role is to neutralize heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 may play a role in inflammation and wound repair. The heparin:PF4 complex is the immunogen in heparin-induced thrombocytopenia, an idiosyncratic autoimmune reaction that sometimes occurs following the injection of heparin. PF4 autoantibodies have also been observed in patients with thrombosis and features resembling HIT although these patients did not receive heparin. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

Fully-Specified Name

Platelet factor 4

Additional Names

Short Name
Display Name
Platelet factor 4 Ql (PPP)
Consumer Name Alpha
Platelet factor 4, Blood

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

First Released
Version 2.09
Last Updated
Version 2.73
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Common US Lab Results Rank

Reference Information

Type Source Reference
Mapping Guidance Regenstrief Help PF4 is used clinically to assess degree of platelet activation but specimen has to be collected meticulously. Some labs use PD4 as short hand for Heparin induced platelet Ab so be careful about mapping. Mapper’s Guide for the Top 2000 plus LOINC Laboratory Observations

Language Variants Get Info

zh-CNChinese (China)
血小板因子 4:存在情况或阈值:时间点:贫血小板血浆:序数型:
nl-NLDutch (Netherlands)
plaatjes factor 4:aanwezigheid:moment:plaatjesarm plasma:ordinaal:
et-EEEstonian (Estonia)
Trombotsüütide 4. faktor:PrThr:Pt:PPP:Ord:
fr-BEFrench (Belgium)
Facteur 4 plaquettaire:PrThr:Temps ponctuel:Plasma pauvre en plaquettes:Ordinal:
fr-CAFrench (Canada)
Facteur 4 plaquettaire:Présence-Seuil:Temps ponctuel:Plasma pauvre en plaquettes:Ordinal:
fr-FRFrench (France)
Facteur 4 plaquettaire:Présence/Seuil:Ponctuel:Plasma pauvre en plaquettes:Qualitatif:
it-ITItalian (Italy)
Fattore piastrinico 4:PrThr:Pt:PPP:Ord:
ko-KRKorean (Korea, Republic of)
혈소판 제4 인자:임의농도:검사시점:혈소판제거혈장:순위척도:
pl-PLPolish (Poland)
czynnik płytkowy 4:obecność lub wartość progowa:Punkt w czasie:Osocze ubogopłytkowe:Porządkowy:
pt-BRPortuguese (Brazil)
Fator plaquetário 4:ACnc:Pt:PPPQ:Ord:
ru-RURussian (Russian Federation)
Пластинка фактор 4:PrThr:ТчкВрм:ОПП:Пор:
es-ARSpanish (Argentina)
factor 4 plaquetario:concentración arbitraria:punto en el tiempo:plasma desplaquetado:ordinal:
es-MXSpanish (Mexico)
Factor plaquetario 4:Presencia o umbral:Punto temporal:Plasma pobre en plaquetas:Ordinal:
es-ESSpanish (Spain)
Factor plaquetario 4:PrThr:Punto temporal:Plasma pobre en plaquetas:Ord:
tr-TRTurkish (Turkey)
Trombosit faktör 4:MevcEşik:Zmlı:TFkP:Srl:

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