LOINC
Version 2.67

34159-4Tau protein [Presence] in Body fluidActive

Part Descriptions

LP28537-6   Tau protein
Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease.

Tau proteins interact with tubulin to stabilize microtubules and promote tubulin assembly into microtubules. Tau has two ways of controlling microtubule stability: isoforms and phosphorylation.

Six tau isoforms exist in brain tissue, and they are distinguished by their number of binding domains. Three isoforms have three binding domains and the other three have four binding domains. The binding domains are located in the carboxy-terminus of the protein and are positively-charged (allowing it to bind to the negatively-charged microtubule). The isoforms with four binding domains are better at stabilizing microtubules than those with three binding domains. The isoforms are a result of alternative splicing in exons 2,3, and 10 of the tau gene.

Phosphorylation of tau is regulated by a host of kinases. For example, PKN, a serine/threonine kinase. When PKN is activated, it phosphorylates tau, resulting in disruption of microtubule organization Taniguchi et al., 2001. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Tau protein

LP7238-1   Body fld
The LOINC "Body fld" System represents any body fluid that does not already have its own named System in LOINC, such as cochlear fluid or chyle. "Body fld" is not a high-level concept that includes all body fluids. Copyright Copyright 2001-2019 American Association for Clinical Chemistry. Source: Regenstrief LOINC

Fully-Specified Name

Component
Tau protein
Property
PrThr
Time
Pt
System
Body fld
Scale
Ord
Method

Additional Names

Short Name
Tau Prot Fld Ql
Display Name
Tau protein Ql (Body fld)

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.10
Last Updated
Version 2.56
Change Reason
Changed answer list from "Normative" to "Example" to fit the current LOINC model.; The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Language Variants Get Info

zh-CNChinese (CHINA)
Tau 蛋白:存在情况或阈值:时间点:体液:序数型:
nl-NLDutch (NETHERLANDS)
tau-proteïne:aanwezigheid:moment:lichaamsvocht:ordinaal:
et-EEEstonian (ESTONIA)
Tau valk:PrThr:Pt:Fx:Ord:
fr-BEFrench (BELGIUM)
Protéine Tau:PrThr:Temps ponctuel:Liquide biologique:Ordinal:
fr-CAFrench (CANADA)
Protéine Tau:Présence-Seuil:Temps ponctuel:Liquide biologique:Ordinal:
fr-FRFrench (FRANCE)
Protéines Tau:Présence/Seuil:Ponctuel:Liquide biologique:Qualitatif:
it-ITItalian (ITALY)
Tau, proteina:PrThr:Pt:Liquido corporeo:Ord:
ko-KRKorean (KOREA, REPUBLIC OF)
타우 단백:임의농도:검사시점:체액:순위척도:
pt-BRPortuguese (BRAZIL)
Proteína tau:ACnc:Pt:LiqOrg:Ord:
ru-RURussian (RUSSIAN FEDERATION)
Тау протеин:PrThr:ТчкВрм:Тело ждк:Пор:
es-ARSpanish (ARGENTINA)
proteína tau:concentración arbitraria:punto en el tiempo:líquido corporal, no especificado:ordinal:
es-ESSpanish (SPAIN)
Proteína Tau:PrThr:Punto temporal:Fluido corporal:Ord:
tr-TRTurkish (TURKEY)
Tau protein:MevcEşik:Zmlı:Vücut sv:Srl:

Example Units

Unit Source
Pos/Neg Original Submission

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=34159-4