34732-8
APOE gene allele 2 [Identifier] in Blood or Tissue by Molecular genetics method
Active
Term Description
APOE gene allele 1 (34731-0)and 2 (34732-8) identify the allele variant present on the two copies of APOE. The original intent of the APOE gene allele 1, 2, 3 and 4 terms was ambiguous due to confusion between allele numbering (i.e., allele 1 and 2, which represent the two copies of a given gene that are present in single cell) and the APOE allele variants e2, e3 and e4. We have updated the APOE gene allele 1 and 2 terms to match other LOINC allele 1 and 2 terms; we also deprecated the APOE gene allele 3 and 4 terms (34733-6 and 34735-1, respectively) and mapped them to LOINC 21619-2, which should be used to report the APOE genotype.
Source: Regenstrief LOINC
Part Description
LP32795-4 APOE gene allele 2
Apolipoproteins are a family of proteins involved in cholesterol transport and metabolism. Apoliprotein E is important in cholesterol transport throughout the body and is encoded by the APOE gene. The three most common forms of apolipoprotein E are E2, E3 and E4, which are encoded by the APOE allele variants e2, e3 (the wild type form) and e4, respectively. The E3 form is responsible for typical cholesterol metabolism. E2 and E4 are associated with alterations in lipid transport and metabolism, and nearly all patients with type III hyperlipoproteinemia (HLP), a familial disorder associated with early atherosclerosis, exclusively make the E2 form of apolipoprotein E. However, 90% of people that only make E2 have cholesterol levels in the normal range, and only about 10% have type III HLP. E4 may also be a marker for Alzheimer's disease. PMID: 11701639
Source: Regenstrief LOINC, PMID: 11701639
Fully-Specified Name
- Component
- APOE gene allele 2
- Property
- ID
- Time
- Pt
- System
- Bld/Tiss
- Scale
- Nom
- Method
- Molgen
Additional Names
- Short Name
- APOE allele2 Bld/T
- Display Name
- APOE gene allele 2 Molgen Nom (Bld/Tiss) [ID]
- Consumer Name Alpha Get Info
- APOE gene allele 2, Blood or tissue specimen
Example Answer List: LL2984-4
Source: Regenstrief LOINC| Answer | Code | Score | Answer ID |
|---|---|---|---|
| APOE e2 | LA21353-0 | ||
| APOE e3 (wild type) | LA21354-8 | ||
| APOE e4 | LA21355-5 |
Basic Attributes
- Class
- MOLPATH.MUT
- Type
- Laboratory
- First Released
- Version 2.11
- Last Updated
- Version 2.73
- Order vs. Observation
- Observation
- Common Test Rank Get Info
- 14960
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-AR | Spanish (Argentina) | gen APOE alelo 2: |
| es-ES | Spanish (Spain) | Alelo 2 del gen APOE: |
| es-MX | Spanish (Mexico) | Alelo 2 del gen APOE: |
| fr-FR | French (France) | APOE gène allèle 2: |
| it-IT | Italian (Italy) | APOE, allele 2 gene: Synonyms: Allele 2 gene APOE Gene APOE Genetica molecolare Identificatore Mutazione genica Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & |
| ko-KR | Korean (Korea, Republic Of) | APOE 유전자 대립유전자 2: |
| nl-NL | Dutch (Netherlands) | APOE-allel 2: Synonyms: APOE gen molgen |
| pt-BR | Portuguese (Brazil) | APOE gene alelo 2: Synonyms: ; |
| ru-RU | Russian (Russian Federation) | APOE ген аллель 2: Synonyms: Аполипопротеина Е ген Идентификатор Кровь Кровь или Ткань Номинальный; |
| tr-TR | Turkish (Turkey) | APOE geni allel 2: |
| zh-CN | Chinese (China) | APOE 基因 等位基因 2: Synonyms: Ⅱ AD2; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=34732-8
LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright