35128-8

Perforin [Units/volume] in Leukocytes

Active

Part Description

LP33048-7 Perforin
Perforin-1 is a protein that in humans is encoded by the PRF1 gene.

Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood.

Perforin is a cytolytic protein found in the granules of CD8 T-cells and NK cells. Upon degranulation, perforin inserts itself into the target cell's plasma membrane, forming a pore. The lytic membrane-inserting part of perforin is the MACPF domain. This region shares homology with cholesterol-dependent cytolysins from Gram-positive bacteria.

Although purified perforin is sufficient to lyse cells at high doses, the biology of perforin itself does not explain the ability of CD8 T-cells and NK cells to induce apoptosis in target cells. This induction of apoptosis may require at least one other granule protein, granzyme B. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

LOINC Names Get Info

Fully-Specified Name: Perforin:ACnc:Pt:WBC:Qn:
Long Common Name: Perforin [Units/volume] in Leukocytes
Short Name: Perforin WBC-aCnc
Display Name: Perforin Qn (WBC)
Consumer Name Alpha Get Info: Perforin, White blood cells

Part Model Get Info

Component
Perforin
LP33048-7
- Analyte
  Perforin
  LP33048-7
  - Component Numerator
    Perforin
    LP33048-7
    - Component Numerator Core
      Perforin
      LP33048-7
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
ACnc
LP6773-8
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
WBC
LP7720-8
- System Core
  WBC
  LP7720-8
- Super System
  NULL
Scale
Qn
LP7753-9
Method
NULL

Basic Attributes

Class: CHEM
Type: Laboratory
First Released: Version 2.11
Last Updated: Version 2.69 (MIN)
Order vs. Observation: Both

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Perforin:Arbitrární koncentrace:Časový bod:Leukocyty:Kvantitativní:
el-GR	Greek (Greece)	Περφορίνη:ACnc:Pt:Αριθμός λευκών αιμοσφαιρίων:Qn: Synonyms: ACnc CHEM Pt Qn Αριθμός λευκών αιμοσφαιρίων Περφορίνη
es-AR	Spanish (Argentina)	perforina:concentración arbitraria:punto en el tiempo:leucocito:cuantitativo:
es-ES	Spanish (Spain)	Perforina:Concentración arbitraria:Punto temporal:Células sanguineas blancas:Qn: Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Actuando:Concentración arbitraria:Punto temporal:células blancas de la sangre:Cuantitativo:
et-EE	Estonian (Estonia)	Perforiin:Acnc:Pt:WBC:Qn: Synonyms: Juhuslik Kvantitatiivne Leukotsüüdid
fr-CA	French (Canada)	Perforine:Concentration arbitraire:Temps ponctuel:Leucocytes:Quantitatif:
fr-FR	French (France)	Perforine:Arbitraire/Volume:Ponctuel:Leucocytes:Numérique:
fr-BE	French (Belgium)	Perforine:Concentration arbitraire:Temps ponctuel:Leucocytes:Quantitatif:
it-IT	Italian (Italy)	Perforina:ACnc:Pt:WBC:Qn: Synonyms: Chimica Concentrazione Arbitraria Globuli bianchi Punto nel tempo (episodio)
ko-KR	Korean (Korea, Republic Of)	퍼포린:임의농도:검사시점:백혈구:정량:
nl-NL	Dutch (Netherlands)	perforine:eenheid/volume:moment:leukocyten:kwantitatief: Synonyms: witte bloedcellen
pt-BR	Portuguese (Brazil)	Perforin:ACnc:Pt:Leucoc:Qn: Synonyms: Pore forming protein; PFN; Arbitrary concentration; Point in time; Random; Leukocytes; White blood cells; Leucocs; Quantitative; QNT; Quant; Quan; Chemistry
ru-RU	Russian (Russian Federation)	Перфорин:ПроизвКонц:ТчкВрм:Лейкоциты:Колич: Synonyms: Количественный Произвольная концентрация Точка во времени;Момент
tr-TR	Turkish (Turkey)	Perforin:SçKons:Zmlı:Lökosit:Kant: Synonyms: WBC
zh-CN	Chinese (China)	穿孔素:任意型浓度:时间点:白细胞:定量型: Synonyms: Perforin;PFN;PFP;穿孔素（Pore-Forming Protein，Perforin，PFN，PFP） WBC;WBCs;白血球;白血细胞任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类可用数量表示的;定量性;数值型;数量型;连续数值型标尺时刻;随机;随意;瞬间

Example Units

Unit	Source
[arb'U]/mL	Example UCUM Units

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.