35794-7
Dirithromycin [Susceptibility] by Minimum inhibitory concentration (MIC)
Active
Part Description
LP17270-7 Dirithromycin
Dirithromycin is a macrolide glycopeptide antibiotic.
Dirithromycin (Dynabac) is a more lipid-soluble prodrug derivative of 9S-erythromycyclamine prepared by condensation of the latter with 2-(2-methoxyethoxy)acetaldehyde. The 9N, 11O-oxazine ring thus formed is a hemi-aminal that is unstable under both acidic and alkaline aqueous conditions and undergoes spontaneous hydrolysis to form erythromycyclamine. Erythromycyclamine is a semisynthetic derivative of erythromycin in which the 9-ketogroup of the erythronolide ring has been converted to an amino group. Erythromycyclamine retains the antibacterial properties of erythromycin oral administration. The prodrug, dirithromycin, is provided as enteric coated tablets to protect it from acid catalyzed hydrolysis in the stomach. Orally administered dirithromycin is absorbed rapidly into the plasma, largely from the small intestine. Spontaneous hydrolysis to erythromycyclamine occurs in the plasma. Oral bioavailability is estimated to be about 10%, but food does not affect absorption of the prodrug.
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Source: Wikipedia, Wikipedia
Fully-Specified Name
- Component
- Dirithromycin
- Property
- Susc
- Time
- Pt
- System
- Isolate
- Scale
- OrdQn
- Method
- MIC
Additional Names
- Short Name
- Dirithromycin Islt MIC
- Display Name
- Dirithromycin MIC [Susc]
- Consumer Name Alpha Get Info
- Susceptibility to Dirithromycin
Basic Attributes
- Class
- ABXBACT
- Type
- Laboratory
- First Released
- Version 2.13
- Last Updated
- Version 2.19
- Order vs. Observation
- Observation
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 50545-3 | Bacterial susceptibility panel by Minimum inhibitory concentration (MIC) |
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG41264-9 | DirithromycinSusc| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-DE | German (Germany) | Dirithromycin: |
| es-AR | Spanish (Argentina) | diritromicina: |
| es-ES | Spanish (Spain) | Diritromicina: |
| es-MX | Spanish (Mexico) | Diritromicina: |
| et-EE | Estonian (Estonia) | Diritromütsiin: Synonyms: Isolaat Juhuslik Minimaalne inhibeeriv kontsentratsioon Tundlikkus |
| fr-CA | French (Canada) | Dirithromycine: |
| fr-FR | French (France) | Dirithromycine: |
| fr-BE | French (Belgium) | Dirithromycine: |
| it-IT | Italian (Italy) | Diritromicina: Synonyms: Concentrazione minima inibitoria Punto nel tempo (episodio) Sensibilità (microrganismi) Suscettibilità agli antibiotici |
| ko-KR | Korean (Korea, Republic Of) | 디리스로마이신: |
| nl-NL | Dutch (Netherlands) | diritromycine: Synonyms: MIC |
| pt-BR | Portuguese (Brazil) | Diritromicina: Synonyms: DynAcac; |
| ru-RU | Russian (Russian Federation) | Диритромицин: Synonyms: Минимальная ингибирующая концентрация (МИК) Порядковый или Количественный Точка во времени; |
| tr-TR | Turkish (Turkey) | Diritromisin: |
| zh-CN | Chinese (China) | 地红霉素: Synonyms: 分离物; |
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