38275-4

Transmissible spongiform encephalopathy [Presence] in Brain by Light microscopy

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Term Description

Histopathologic exam without immunostain to identify the presence of a transmissible spongiform encephalopathy (TSE), such as Scrapie, CWE, and BSE. Findings on light microscopy (plaques, neuronal loss, etc.) indicate the disease process.
Source: Regenstrief LOINC

Part Description

LP173528-3   Transmissible spongiform encephalopathy
Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a group of progressive conditions (encephalopathies) that affect the brain and nervous system of many animals, including humans. According to the most widespread hypothesis they are transmitted by abnormal prions, though some other data suggest an involvement of a Spiroplasma infection. Mental and physical abilities deteriorate and a myriad of tiny holes appear in the cortex causing it to appear like a sponge (hence spongiform) when brain tissue obtained at autopsy is examined under a microscope. The disorders cause impairment of brain function, including memory changes, personality changes and problems with movement that worsen over time. Most TSEs are sporadic and occur in animals. Prion diseases of animals in include classical bovine spongiform encephalopathy (BSE) (C-type), atypical (H or L-type) BSE, Scrapie, atypical scrapie, Nor98, and chronic wasting disease (CWE). H-type and L-type BSE were named based on abnormal prion bands migrating to a higher (H) or lower (L) position on western blot analysis compared to the classical BSE (C-type) prion protein. Prion diseases of humans include classic Creutzfeldt-Jakob disease, new variant Creutzfeldt-Jakob disease (nvCJD, a human disorder related to Bovine spongiform encephalopathy), Gerstmann-Sträussler-Scheinker syndrome, fatal familial insomnia and kuru. These conditions form a spectrum of diseases with overlapping signs and symptoms. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Transmissible spongiform encephalopathy

Fully-Specified Name

Component

Transmissible spongiform encephalopathy

Property

PrThr

Time

Pt

System

Brain

Scale

Ord

Method

Microscopy.light

Additional Names

Short Name

TSE Brain Ql Micro

Display Name

Transmissible spongiform encephalopathy LM Ql (Brain)

Consumer Name Alpha Get Info

Transmissible spongiform encephalopathy, Brain

Basic Attributes

Class

MICRO

Type

Laboratory

First Released

Version 2.13

Last Updated

Version 2.56

Change Reason

Changed Component from Prion protein.abnormal since it is only the disease process the pathologist sees on light microscopy.; The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.

Order vs. Observation

Both

Language Variants Get Info

Related Names

• abnormal prion protein
• Cerebral
• Cerebrum
• Head
• ID
• Infectious Disease
• InfectiousDisease
• Intracranial
• LM
• Micro
• Microbiology
• Micros
• Microscopic
• Neuro
• Neurology
• Ordinal
• Point in time
• PR
• Prion diseases
• QL
• Qual
• Qualitative
• Random
• Screen
• TSE

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CodeSystem lookup

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=38275-4

LOINC Copyright

Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2024, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.