Version 2.77

Part Descriptions

LP14697-4   Thyroglobulin
Thyroglobulin (Tg) is a protein produced by and used entirely within the thyroid gland. Thyroglobulin is used by the thyroid gland to produce the thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is stored in the thyroid in follicle cysts surrounded by colloid cells. Via a reaction with the enzyme thyroperoxidase, iodine is covalently bound to tyrosine residues in thyroglobulin molecules, forming monoiodotyrosine (MIT) and diiodotyrosine (DIT). Thyroxine is produced by linking two moieties of DIT. Combining one particle of MIT and one particle of DIT produces triiodothyronine. Proteases in lysosomes digest iodinated thyroglobulin, releasing T3 and T4. Thyroglobulin levels in the blood can be used as a tumor marker for certain kinds of thyroid cancer. Thyroglobulin levels in the blood can also be elevated in cases of Graves Disease. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Thyroglobulin (Wikipedia)

LP14697-4   Thyroglobulin
Thyroglobulin (Tg) is a glycoprotein homodimer produced by the thyroid gland. It is important in the synthesis of thyroxine and triiodothyronine, and is where the inactive forms of thyroid hormone and iodine are stored. Mutations in the Tg gene cause thyroid dyshormonogenesis resulting in goiter, and can be associated with moderate to severe congenital hypothyroidism. Polymorphisms in the Tg gene are associated with susceptibility to autoimmune thyroid diseases such as Graves disease or Hashimoto thyroiditis. [NCBI Gene ID:7038] Tg is an established tumor marker used in the diagnosis of differentiated thyroid carcinoma. PMID: 9543128 Source: Regenstrief LOINC

LP39996-1   Thyroglobulin Ab
Circulating immunoglobulins directed against thyroglobulin are commonly present in patients with autoimmune (Hashimoto) thyroiditis and, to a lesser extent, Graves disease. Thyroglobulin is a 660-kd protein precursor of thyroid hormones. Thyroglobulin antibodies are present in the sera of approximately 70% of patients with autoimmune thyroiditis. The principal use of the test is to confirm that a patient's diffuse goiter and/or hypothyroidism is due to autoimmune thyroiditis. The test may also help distinguish Graves disease from toxic nodular goiter. Although thyroglobulin antibodies are present less often than thyroid microsomal antibodies (eg, thyroid peroxidase antibodies, anti-TPO) in patients with autoimmune thyroid diseases, screening fro both immunoglobulins increases diagnostic sensitivity. Thyroglobulin antibodies may be detected in individuals without clinically significant thyroid disease. They do not define the patient's thyroid functional status. Source: Quest Diagnostics Inc., Thyroglobulin antibodies

Reference Information

Type Source Reference
Webcontent Lab Tests Online®Copyright Copyright © 2021 Lab Tests Online. All rights reserved. Thyroid Antibodies

Fully-Specified Name

Component
Thyroglobulin Ab
Property
Titr
Time
Pt
System
Ser
Scale
SemiQn
Method
IF

Additional Names

Short Name
Thyroglob Ab Titr Ser IF
Display Name
Thyroglobulin Ab IF (S) [Titer]
Consumer Name Alpha Get Info
Thyroglobulin antibody, Blood

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.14
Last Updated
Version 2.75
Order vs. Observation
Both
Common Test Rank Get Info
19203

Member of these Groups Get Info

LOINC Group Group Name
LG15249-2 Thyroglobulin Ab|Titr|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
es-AR Spanish (Argentina) [anticuerpo anti - ] tiroglobulina [Ac]:factor de dilución (titulación):punto en el tiempo:suero/plasma:cuantitativo:inmunofluorescencia
es-ES Spanish (Spain) Tiroglobulina Anticuerpos:Titulo / Factor de dilución:Punto temporal:Suero:Semicuantitativo:Inmunofluorescencia (IF)
Synonyms: Semicuantitativo
es-MX Spanish (Mexico) Tiroglobulina Ab:Título:Punto temporal:Suero:Cuantitativo:Inmunofluorescencia (IF)
fr-CA French (Canada) Thyroglobuline , Ac:Titre:Temps ponctuel:Sérum:SemiQn:Immunofluorescence
fr-FR French (France) Thyroglobuline anticorps:Titre:Ponctuel:Sérum:Numérique:Immunofluorescence
it-IT Italian (Italy) Tireoglobulina Ab:Titr:Pt:Siero:SemiQn:IF
Synonyms: anticorpo Immunofluorescenza (IF) Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant Titolo
ko-KR Korean (Korea, Republic Of) 갑상샘글로불린 항체:역가:검사시점:혈청:정량:면역형광
nl-NL Dutch (Netherlands) thyreoglobuline As:titer:moment:serum:semikwantitatief:immunofluorescentie
Synonyms: antistof; antilichaam IF
pt-BR Portuguese (Brazil) Tireoglobulina Ac:Título:Pt:Soro:Qn:Imunofluorescência
Synonyms: AntiTiroglob; TgAcs; Tiroglob; Thyglobulin; Thyroglbn; Tg; Dilution factor; Titer; Titre; Ttr; Titered; Point in time; Random; Serum; SR; Quantitative; QNT; Quant; Quan; ACIF; FA; Fluorescent antibody; Immune fluorescence; Fluoresent; Immunoflour; Immunofluor; Immunofluorescence; IFA; Time Resolved Fluorescence; Anticomplement Immunofluorescence; TRF; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; Serology
zh-CN Chinese (China) 甲状腺球蛋白 抗体:滴定度:时间点:血清:半定量型:免疫荧光法
Synonyms: Ab;自身抗体 IFA法;IF法;抗补体免疫荧光法;时间分辨荧光法;荧光原位杂交技术;荧光原位杂交法;荧光抗体 TG;甲状球蛋白;甲状腺球朊;甲状腺球蛋白（Thyroglobulin，TG，Tg）;甲状腺球蛋白特异性 TgAbs 抗甲状腺球蛋白 效价;滴定浓度;滴定率;滴定量;滴度;稀释倍数;稀释因子;稀释系数 时刻;随机;随意;瞬间 甲状腺球蛋白 Ab 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Example Units

Unit Source
titer REGENSTRIEF
{titer} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=38504-7