Version 2.80

Part Description

LP35095-6   inFLIXimab
Infliximab is a genetically engineered immunoglobulin 1 murine-human chimeric monoclonal antibody against tumor necrosis factor alpha (TNFα). The murine portion is the part of the antibody that binds to TNFα while the human portion preserves functional immune capacity. Infliximab is used to treat Crohn's disease and, in particular, in treating the closure of intestinal or perianal fistulas in patients with acute intestinal involvement who have been unresponsive to other treatments. TNFα is a cytokine that acts to increase the inflammatory process in CD, RA, psoriasis and spondylarthropathy. The primary mechanism of infliximab is to combine with the inactivate soluble transmembrane TNFα. However, infliximab also modulates TNFα-producing cells through complement fixation of antibody-dependent T lymphocytes and monocytes by binding them to the IgG1 fc portion of infliximab. There is also a subsequent down-regulation of other inflammation-producing cytokines and a reduction of the level of chemokines and endothelial adhesion molecules. Negative side effects of infliximab include fibrostenosing CD and sepsis. PMID: 18360638 Source: Regenstrief LOINC

Fully-Specified Name

Component
inFLIXimab
Property
MCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Additional Names

Long Common Name
inFLIXimab [Mass/volume] in Serum or Plasma
Short Name
inFLIXimab SerPl-mCnc
Display Name
inFLIXimab [Mass/Vol]
Consumer Name Alpha Get Info
inFLIXimab, Blood

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 2.15
Last Updated
Version 2.73 (MIN)
Order vs. Observation
Both
Common Test Rank Get Info
2646

Member of these Panels

LOINC Long Common Name
103791-0 Infliximab and Infliximab Ab Panel - Serum or Plasma

Member of these Groups Get Info

LOINC Group Group Name
LG16182-4 Infliximab|MCnc|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: Infliximab
de-DE German (Germany) Infliximab:Massenkonzentration:Zeitpunkt:Serum oder Plasma:Quantitativ:
el-GR Greek (Greece) Ινφλιξιμάμπη:MCnc:Pt:Ορός/Πλάσμα:Qn:
Synonyms: MCnc Ινφλιξιμάμπη
es-ES Spanish (Spain) Infliximab:Concentración de masa:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) inFLIXimab:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:
et-EE Estonian (Estonia) Infliksimaab:MCnc:Pt:S/P:Qn:
Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-CA French (Canada) Infliximab:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
Synonyms: #REF!
fr-FR French (France) Infliximab:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:
fr-BE French (Belgium) Infliximab:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
it-IT Italian (Italy) Infliximab:MCnc:Pt:Siero/Plasma:Qn:
Synonyms: Concentrazione di Massa Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma
ko-KR Korean (Korea, Republic Of) Infliximab:질량농도:검사시점:혈청/혈장:정량:
nl-NL Dutch (Netherlands) infliximab:massa/volume:moment:serum of plasma:kwantitatief:
pt-BR Portuguese (Brazil) InfliximAc:MCnc:Pt:Sor/Plas:Qn:
Synonyms: Remicade; Mass concentration; Level; Point in time; Random; SerPl; SerPlas; SerP; Serum; SR; Plasma; Pl; Plsm; Quantitative; QNT; Quant; Quan; Drugs; DRUG/TOXICOLOGY; DRUG/TOXICOLOGY
ru-RU Russian (Russian Federation) Инфликсимаб:МассКонц:ТчкВрм:Сыв/Плаз:Колич:
Synonyms: Количественный Массовая концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) İnfliksimab:KütlKons:Zmlı:Ser/Plaz:Kant:
zh-CN Chinese (China) 英利昔单抗:质量浓度:时间点:血清/血浆:定量型:
Synonyms: Infliximab 单抗;嵌合了肿瘤坏死因子α（TNF-α）的单克隆抗体;目前主要用于治疗类风湿性关节炎（RA）和克隆病（CD）;英利昔;英利昔单克隆抗体;因福利美;抗炎单克隆抗体 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 毒品 毒品类 水平;浓度;质量浓度(单位体积) 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类 血清或血浆

Example Units

Unit Source
mcg/mL REGENSTRIEF
ug/mL Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=39803-2